Yalçın Ülker, Gül Merve

Name Variants

Yalçin Ülker G.
Ülker, M.
Gül Merve Yalçın ÜLKER
G. M. Ulker
Ulker, Merve
G. Merve Ulker
Ulker, Gul
Gül M. Ülker
Gul Merve Yalcin ULKER
Yalçın Ülker G.
Yalçın Ülker, Gül Merve
Gul M. Ulker
Ülker, G.
Ulker, Yalcin
Yalcin-Ulker G.
G. M. Ülker
G.,Yalçın Ülker
Ulker, Y.
Gül Merve Yalçın Ülker
Ulker, G.
Ülker, Yalçın
Ülker, Y.
Ülker Gül Merve Yalçın
Ulker, M.
Yalcin-Ülker G.
Ulker Gul Merve Yalcin
G. M. ULKER
G. M. ÜLKER
Gül Merve, Yalçın Ülker
Ülker, Merve
Ülker, Gül
ÜLKER Gül Merve Yalçın
ULKER Gul Merve Yalcin
G. M. Yalçın Ülker
G. Merve Ülker
Gul Merve Yalcin Ulker
Yalcin Ulker, Gul Merve
Ulker, Gul Merve Yalcin
Yalcin, Gul Merve
Gül Merve YALÇIN ÜLKER
Yalcin-Ulker, Gul Merve
Yalçın, Gül Merve Ülker

Job Title

Dr.Öğr.Üyesi

Email Address

merve.yalcin@okan.edu.tr

Main Affiliation

Ağız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery

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Scholarly Output

16

Articles

16

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0

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Now showing 1 - 10 of 16

Citation - WoS: 3
Citation - Scopus: 4
Is there any predictive bone parameter for implant stability in 2-dimensional and 3-dimensional radiologic images?
(Elsevier Science inc, 2021) Arsan, Belde; Yalcin-Ulker, Gul Merve; Meral, Deniz Gokce; Erdem, Tamer Lutfi; Ağız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery
Objectives. This ex vivo study aimed to compare radiomorphometric parameters between 2-dimensional (2-D) and 3-dimensional (3-D) radiographs and evaluate the influence of preoperative radiologic bone parameters on the clinical outcomes of implant stability. Study Design. Implant recipient sites in fresh bovine blocks were evaluated on panoramic radiographs for gray value (GV), fractal dimension (FD), number of connected trabeculae (Co), and density of connected trabeculae (CoD). Cone beam computed tomography (CBCT) scans were evaluated for trabecular thickness (TbTh), cortical thickness (CTh), degree of anisotropy (DA), FD, and Co. Insertion torque (IT) and implant stability quotient (ISQ) were measured. Results. GV was significantly correlated with all parameters in 2-D and 3-D images except FD in 2-D and Co in 3-D, and with all surgical parameters (P <= .029). Co and CoD values on panoramic radiographs had significant correlation with TbTh, CTh, and DA values on CBCT images (P < .001). All 2-D parameters and TbTh and CTh in the CBCT data were significantly correlated with IT only (P <= .047). Only GV was correlated with ISQ measurements (P <= .029). Conclusion. GV, Co, and CoD values on panoramic radiographs reflect the architecture of trabecular bone and the thickness of cortical bone, and might help predict implant stability in clinical situations.
Citation - WoS: 18
Citation - Scopus: 25
Effect of a novel bioceramic root canal sealer on the angiogenesis-enhancing potential of assorted human odontogenic stem cells compared with principal tricalcium silicate-based cements
(Univ Sao Paulo Fac Odontologia Bauru, 2020) Olcay, Keziban; Tasli, Pakize Neslihan; Guven, Esra Pamukcu; Ulker, Gul Merve Yalcin; Ogut, Emine Esen; Ciftcioglu, Elif; Sahin, Fikrettin; Endodonti / Endodontics; Ağız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery
Objective: This study evaluated the angiogenesis-enhancing potential of a tricalcium silicate-based mineral trioxide aggregate (ProRoot MTA), Biodentine, and a novel bioceramic root canal sealer (Well-Root ST) in human dental pulp stem cells (hDPSCs), human periodontal ligament stem cells (hPLSCs), and human tooth germ stem cells (hTGSCs). Methodology: Dulbecco's modified Eagle's medium was conditioned for 24 h by exposure to ProRoot MTA, Biodentine, or Well-Root ST specimens (prepared according to the manufacturers' instructions). The cells were cultured in these conditioned media and their viability was assessed with 3-(4,5-dimethyl-thiazol-2-yl)-5-(3-carboxy-methoxy-phenyl)-2-(4-sulfo-phenyl)-2H tetrazolium (MTS) on days 1, 3, 7, 10, and 14. Angiogenic growth factors [platelet-derived growth factor (PDGF), basic fibroblast growth factor (FGF-2), and vascular endothelial growth factor (VEGF)] were assayed by sandwich enzyme-linked immunosorbent assay (ELISA) on days 1, 7, and 14. Human umbilical vein endothelial cell (HUVEC) migration assays were used to evaluate the vascular effects of the tested materials at 6-8 h. Statistical analyses included Kruskal-Wallis, Mann-Whitney U, and Friedman and Wilcoxon signed rank tests. Results: None of tricalcium silicate-based materials were cytotoxic and all induced a similar release of angiogenic growth factors (PDGF, FGF-2, and VEGF) (p>0.05). The best cell viability was observed for hDPSCs (p<0.05) with all tricalcium silicate-based materials at day 14. Tube formation by HUVECs showed a significant increase with all tested materials (p<0.05). Conclusion: The tricalcium silicate-based materials showed potential for angiogenic stimulation of all stem cell types and significantly enhanced tube formation by HUVECs.
Alt yirmi yaş dişlerinin mandibular kanalla olan ilişkisinin panoramik radyografilerde ve konik ışınlı bilgisayarlı tomografi görüntülerinde incelenmesi
(2016) Yalçın, Gül Merve Ülker; Tomruk, Ceyda Özçakır; İlgüy, Dilhan; Şençift, Mehmet Kemal; Çapar, Gonca Duygu; Ersan, Nilüfer; Ağız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery
Amaç: Alt yirmi yaş dişlerinin çekimi öncesinde, oluşabilecek inferior alveolar sinir hasarının önlenmesi için radyografik değerlendirme yapılması gerekmektedir. Bu çalışmanın amacı alt yirmi yaş dişlerinin kökleri ile mandibular kanalın ilişkisini sunan panoramik radyografilerdeki göstergelerin, konik ışınlı bilgisayarlı tomografi (KBIT) görüntüleri ile karşılatırılarak, güvenilirliğinin belirlenmesidir.Gereç ve yöntem: Çalışmada 73 hastanın 105 alt yirmi yaş dişi değerlendirilmiştir. Panoramik radyografilerde mandibular kanal devamlılığının kaybolması ve kök ucunda radyolusensi olması kriterlerine bakılarak, KBIT görüntüleri ile karşılaştırılmış ve bu üç boyutlu görüntülerde kökler ile inferior alveolar sinirin ilişkisi ve lingual korteksin durumu değerlendirilmiştir.Bulgular: Araştırmacılar arası güvenilirliğin sağlanması amacı ile kappa hesaplaması yapılmış ve bu hesaplamanın sonucunda Kappa değeri 0,88 olarak çıkmıştır. Panoramik radyografide kanal devamlılığının kaybolduğu 39 yirmi yaş dişinde (%81,25), KBIT görüntüleri incelendiğinde kökler ve kanal arasında ilişki görülürken; kök ucunda radyolusensinin görüldüğü 47 yirmi yaş dişi (% 82,46) incelendiğinde kökler ve kanal arasında ilişki görülmüştür. Kök ucunda radyolüsensi gözlenmesi ve kanal devamlılığının kaybolması durumları istatistiksel olarak anlam teşkil etmektedir. Panoramik radyografide kanal devamlılığının kaybolduğu 11 yirmi yaş dişinin (%19,3), KBIT görüntüleri incelendiğinde kökün veya köklerin lingual korteksi perfore etmiş olduğu gözlenmiştir. Kök ucunda radyolusensinin görüldüğü yirmi yaş dişlerinden sadece 1 tanesinde (%2.08) lingual kortekste perforasyon gözlenmiştir. Kök ucunda radyolusensi gözlenmesi ve kanal devamlılığının kaybolması durumları, lingual korteksin durumu istatistiksel olarak bir anlam teşkil etmemektedir.Sonuç: Bu çalışmanın sonucuna dayanarak, panoramik radyografilerde bu kriterlere sahip mandibular yirmi yaş dişlerinin cerrahi çekimi öncesinde inferior alveoler sinir hasarının önlenmesi amacı ile tomografi görüntülerinin değerlendirilmesini öneriyoruz.
Citation - WoS: 13
Citation - Scopus: 13
Preventive Effect of Phosphodiesterase Inhibitor Pentoxifylline Against Medication-Related Osteonecrosis of the Jaw: An Animal Study
(W B Saunders Co-elsevier inc, 2017) Yalcin-Ulker, Gul Merve; Cumbul, Alev; Duygu-Capar, Gonca; Uslu, Unal; Sencift, Kemal; Ağız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery
Purpose: The aim of this experimental study was to investigate the prophylactic effect of pentoxifylline (PTX) on medication-related osteonecrosis of the jaw (MRONJ). Materials and Methods: Female Sprague-Dawley rats (n=33) received zoledronic acid (ZA) for 8 weeks to create an osteonecrosis model. The left mandibular second molars were extracted and the recovery period lasted 8 weeks before sacrifice. PTX was intraperitoneally administered to prevent MRONJ. The specimens were histopathologically and histomorphometrically evaluated. Results: Histomorphometrically, between the control and ZA groups, there was no statistically significant difference in total bone volume (P=.999), but there was a statistically significant difference in bone ratio in the extraction sockets (P<.001). A comparison of the bone ratio of the ZA group with the ZA/PTX group (PTX administered after extraction) showed no statistically significant difference (P=.69), but there was a statistically significant difference with the ZA/PTX/PTX group (PTX administered before and after extraction; P=.008). Histopathologically, between the control and ZA groups, there were statistically significant differences for inflammation (P=.013), vascularization (P=.022), hemorrhage (P=.025), and regeneration (P=.008). Between the ZA and ZA/PTX groups, there were no statistically significant differences for inflammation (P=.536), vascularization (P=.642), hemorrhage (P=.765), and regeneration (P=.127). Between the ZA and ZA/PTX/PTX groups, there were statistically significant differences for inflammation (P=.017), vascularization (P=.04), hemorrhage (P=.044), and regeneration (P=.04). Conclusion: In this experimental model of MRONJ, it might be concluded that although PTX, given after tooth extraction, improves new bone formation that positively affects bone healing, it is not prophylactic. However, PTX given before tooth extraction is prophylactic. Therefore, PTX might affect healing in a positive way by optimizing the inflammatory response. (C) 2017 American Association of Oral and Maxillofacial Surgeons
Ağız, Diş ve Çene Cerrahisi lisans ve öğretim üyesi kliniklerine başvuran hastaların dental anksiyete ve korku açısından değerlendirilmesi
(2022) Gül Merve Yalçın Ülker; Deniz Gökçe MERAL; Aleyna Kucur; Ağız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery
Giriş ve Amaç: Dental korku ve anksiyete, hem diş hekimlerini dental tedaviler sırasında zorlamakta; hem de hastaların ağız ve diş sağlığını olumsuz yönde etkilemektedir. Bu çalışmada Ağız, Diş ve Çene Cerrahisi lisans ve öğretim üyesi kliniklerine başvuran hastaların sosyodemografik özellikleri, duygusal ce- vapları ve dental tecrübelerine göre dental anksiyete ve korku seviyelerindeki farklılıkların incelenmesi ve tedavilerini yapan hekiminin tecrübesinin bu parametrelere etkisinin incelenme- si amaçlanmıştır. Gereçler ve Yöntem: Çalışmada Ağız, Diş ve Çene Cerrahi- si Anabilim Dalı lisans ve öğretim üyesi kliniklerine diş çeki- mi için başvuran hastalara 10 adet demografik bilgilerini ve daha öncekileri dental tecrübelerini sorgulayan, 11 adet den- tal korkuyu sorgulayan, 5 adet de dental anksiyeteyi sorgu- layan sorular elektronik bir anket aracılığı ile tedavilerinden hemen önce yöneltilmiştir. Normal dağılıma uygunluk Kolmo- gorov-Smirnov ve Shapiro-Wilk testi ile incelenmiştir.Dental korku ve anksiyete puanlarının karşılaştırılmasında Mann-W- hitney-U ve Kruskal Wallis testi kullanılmıştır. Önem düzeyi p<0,05 olarak alınmıştır. Bulgular: Lisans ve öğretim üyesi kliniklerine başvuru tiple- rine göre hastaların dental korku düzeylerindeki farklılıklar is- tatistiksel olarak anlamlı bulunmuş ve lisans kliniğinde daha yüksek olduğu tespit edilmiştir (p=0,036).Hastalar cinsiyete göre dental korku ve anksiyete açısından karşılaştırıldığında, erkeklerde her iki değişkenin de istatistiksel olarak anlamlı derecede daha yüksek seviyelerde olduğu tespit edilmiştir (p=0,002;p<0,001).Yaş gruplarına göre dental korku düzeyi- nin en yüksek 45-54 yaş grubundaki, en düşük 18-29 yaş gru- bundaki hastalarda olduğu gözlenmiştir(p=0,009). Sonuç: Dental korku açısından tedavi olunan kliniğe göre bir fark gözlenirken, dental anksiyete açısından bir farklılık göz- lenmemiştir.Çalışmanın sonucuna göre erkek hastaların den- tal anksiyete ve korku düzeylerinin daha yüksek olduğu ve 45-54 yaş grubunun en yüksek dental korku seviyesine sahip olduğu gözlenmiştir. Bu farklılıkların geçmiş dental tecrübe- lerden kaynaklanabileceği sonucuna varılmıştır.
Citation - WoS: 4
Citation - Scopus: 5
Use of Leukocyte-rich and Platelet-rich Fibrin (L-PRF) Adjunct to Surgical Debridement in the Treatment of Stage 2 and 3 Medication-Related Osteonecrosis of the Jaw
(Lippincott Williams & Wilkins, 2023) Yalcin-Ulker, Gul Merve; Duygu, Gonca; Tanan, Gamze; Cakir, Merve; Meral, Deniz Gokce; Ağız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery
Medication-related osteonecrosis of the jaw (MRONJ) is characterized by exposed necrotic bone persisting for more than 8 weeks in the maxillofacial region in patients using antiresorptive or antiangiogenetic drugs for several treatment options like bone metastasis or osteoporosis. There are several treatment options studied in scientific literature, and one of them with promising results is using platelet concentrates adjunct to surgical therapy. The aim of this study is to examine the therapeutic effect of leukocyte and platelet-rich fibrin (L-PRF) on patients with MRONJ. This 2-centered study investigated patients referred to oral and maxillofacial surgery departments of 2 university clinics between the years 2014 and 2020 with the diagnosis of MRONJ. Demographic data, the indication of the drug usage, drug type, duration, administration route, and systemic comorbidities of the patients were recorded. L-PRF was applied to 20 osteonecrotic lesions of 19 patients following surgical debridement. The male/female ratio was 5/14. Except 1 of the patients, all of the indications of medication were neoplasia-related. The mean follow-up period of patients was 27.9 & PLUSMN;9.2 months. Most common antirezorptive drug was zoledronate (84.2%). Complete resolution was observed in 16 necrosis sites (80%). It could be concluded that the use of L-PRF may represent an important adjunct in the surgical management of MRONJ.
Citation - WoS: 3
Citation - Scopus: 2
Preventive effect of doxycycline sponge against bisphosphonate-related osteonecrosis of the jaws: an animal study
(Taylor & Francis Ltd, 2016) Capar, Gonca Duygu; Sapmaz-Metin, Melike; Kutan, Esma; Tomruk, Ceyda Ozcakir; Yalcin, Gul Merve; Er, Nilay; Ozfidan, Gulnur Kizilay; Ağız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery
The aim of this study is to investigate the effect of doxycycline collagen sponge on bisphosphonate-related osteonecrosis of the jaw (BRONJ) and the level of serum biomarkers as an indicator of osteonecrosis. Twenty-four rats were divided into four groups. Animals in the control group were injected with saline and animals in Groups I, II and III were injected with zoledronate three times a week for eight weeks. After eight weeks, the following procedures were performed in each group. In Group I: extraction of maxillary first molar, in Group II: extraction of maxillary first molar and mucoperiosteal coverage was performed and in Group III: extraction of maxillary first molar and mucoperiosteal coverage with doxycycline collagen sponges was performed. At the end of 16 weeks, all animals were sacrificed. Serum collagen type I C-telopeptide (CTx), tartrate-resistant acid phosphatase (TRACP 5b) and alkaline phosphatase (ALP) levels' analysis, clinical examination, histological and histomorphometrical analysis were performed. As a result no significant difference in CTx, TRACP 5b and ALP levels was observed between groups. Complete mucosal healing was observed in all animals in the control group and 66.7% of animals in Group III. The necrotic bone area in Group III was significantly lower than the other groups (p < 0.01). Statistically significant difference was observed between groups in terms of detached osteoclast number (p < 0.01). In conclusion, local application of doxycycline could have a positive effect in reducing the risk of BRONJ in rats.
Citation - WoS: 0
Citation - Scopus: 0
Effect of Residual Bone Height and Implant Macro-Design on Primary Stability in Sinus Floor Elevation: An Ex Vivo Study
(Allen Press inc, 2023) Tokuc, Berkay; Cakir, Merve; Ulker, Gul Merve Yalcin; Geckili, Onur; Meral, Deniz Gokce; Kan, Bahadir; Ağız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery
The objective was to evaluate the influence of residual bone height (RBH) and implant macro -design on the primary stability (PS) of implants using a simultaneous sinus floor elevation (SFE) and implant insertion model. Fresh bovine rib samples that resembled type -IV density that were confirmed by computerized tomography were prepared to represent 4 groups of varying RBHs (3, 6, 9, 15 mm). To simulate simultaneous implant insertion with SFE, 120 implants in different macro -designs (group R: NobelReplace; group P: NobelParallel; group A: NobelActive, Nobel Biocare, Gothenburg, Sweden) were randomly inserted at RBHs of 3, 6, 9, and 15 mm in each rib. The implant stability quotient (ISQ) was measured immediately after implant insertion. RBH and implant macro -design have an impact on ISQ values (P < .001). ISQ values were the highest with RBH of 15 mm, followed by RBHs of 9, 6, and 3 mm. (P < .001). There was no statistically significant difference between different implant macro -designs at RBHs of 3 and 15 mm regarding ISQ values (P = .111, P = .551). ISQ values of group P were higher than those of group R and group A at an RBH of 6 mm (P = .049, P = .029). ISQ values were also higher in group P compared to group A at an RBH of 9 mm (P = .006). A higher PS may be expected in sites with higher RBH, regardless of the macro -design. In addition, cylindric implant design may enhance the PS at RBHs of 6 and 9 mm in simultaneous implant insertion with SFE.
Citation - WoS: 14
Citation - Scopus: 19
Histopathological evaluation of the effect of systemic thymoquinone administration on healing of bone defects in rat tibia
(Taylor & Francis Ltd, 2017) Arslan, Ahmet Hamdi; Tomruk, Ceyda Ozcakir; Meydanli, Elif Guzel; Ozdemir, Ilkay; Capar, Gonca Duygu; Kutan, Esma; Ulker, Gul Merve Yalcin; Ağız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery
The aim of the present study was to assess the systemic effect of thymoquinone (TQ) on bone healing by starting TQ administration, either 40 days before, or on the day of the surgical procedure and continuing during the healing period of 28 days. Eighteen experimental rats were divided into three groups and defects were created in their tibias. The following procedures were performed for each group: Control group (C): No systemic drug administration (n D 6); Test group 1 (T1): Systemic TQ was administered daily starting 40 days before creation of the defect and additionally during the post-operative healing period of 28 days (n = 6); Test group 2 (T2): Systemic TQ was administered daily after creation of the defect and during the healing period of 28 days (n = 6). Quantitative measurement for new bone formation, osteoblast lining and semi-quantitative measurement of capillary intensities were examined and statistically analysed. There was a significant increase in the ratio of new bone per total defect area and new bone trabeculae lined by active osteoblasts in both test groups (T1 and T2) compared to control group (p < 0.05). However the difference between T1 and T2 was not statistically significant. TQ-administered groups also showed an increase in capillary intensity in the defect area compared to the control group (p < 0.05). Systemic administration of TQ either starting 40 days before or on the day of surgery accelerated new bone formation in a rat model and can be advocated as an adjunct to expedite bone healing.
Citation - WoS: 9
Citation - Scopus: 9
A city-wide survey of dental students' opinions on undergraduate oral surgery teaching
(Wiley, 2020) Burdurlu, Muammer Cagri; Cabbar, Fatih; Dagasan, Volkan; Cukurova, Zeynep Gulen; Doganay, Ozge; Yalcin Ulker, Gul Merve; Ozcakir Tomruk, Ceyda; Ağız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery
Purpose This study aimed to carry out a city-wide survey to evaluate undergraduate students' opinions on their oral surgery training by measuring their self-confidence. Materials and Methods A cross-sectional survey of 383 3rd year, 412 4th year and 363 5th year undergraduate dental students from six dental schools in Istanbul with a mean age of 22.73 +/- 1.55 was conducted towards the end of the academic year. A web link to the questionnaire was sent to the contact person at the participating dental schools. The questionnaires were anonymously evaluated. Descriptive statistics were calculated, and Chi-square tests were performed to examine the data. A P-value of In total, 1158 responses were returned, representing 67% of the overall students in the 2018-2019 academic year. The male respondents were significantly more self-confident than females in the general aspects of surgical skills. More than half of the respondents (53%) felt confident in oral surgery knowledge to undertake independent practice. Although 5th year respondents felt more confident in the general aspect of the questionnaire, their ability of differentiation of odontogenic and non-odontogenic pain was lower than their counterparts. The majority (86%) of the participants disagreed that the only knowledge required for oral surgery was that of tooth and jaw anatomy. Conclusion This survey revealed perceived confidence in tooth and retained root extraction. The male respondents were found to be more self-confident. There is a need for improvement in surgical skills, recognition of malignancies and differentiation of the origin of the pain.

Yalçın Ülker, Gül Merve

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