Yalçın Ülker, Gül Merve

Name Variants

Yalçin Ülker G.
Ülker, M.
Gül Merve Yalçın ÜLKER
G. M. Ulker
Ulker, Merve
G. Merve Ulker
Ulker, Gul
Gül M. Ülker
Gul Merve Yalcin ULKER
Yalçın Ülker G.
Yalçın Ülker, Gül Merve
Gul M. Ulker
Ülker, G.
Ulker, Yalcin
Yalcin-Ulker G.
G. M. Ülker
G.,Yalçın Ülker
Ulker, Y.
Gül Merve Yalçın Ülker
Ulker, G.
Ülker, Yalçın
Ülker, Y.
Ülker Gül Merve Yalçın
Ulker, M.
Yalcin-Ülker G.
Ulker Gul Merve Yalcin
G. M. ULKER
G. M. ÜLKER
Gül Merve, Yalçın Ülker
Ülker, Merve
Ülker, Gül
ÜLKER Gül Merve Yalçın
ULKER Gul Merve Yalcin
G. M. Yalçın Ülker
G. Merve Ülker
Gul Merve Yalcin Ulker
Yalcin Ulker, Gul Merve
Ulker, Gul Merve Yalcin
Yalcin, Gul Merve
Gül Merve YALÇIN ÜLKER
Yalcin-Ulker, Gul Merve
Yalçın, Gül Merve Ülker

Job Title

Dr.Öğr.Üyesi

Email Address

merve.yalcin@okan.edu.tr

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Scholarly Output

16

Articles

16

Citation Count

0

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0 Scholarly Output Search Results

Now showing 1 - 10 of 16

Citation Count: 3
Comparison of the effect of postoperative care agents on human gingival fibroblasts: a preliminary study
(Istanbul Univ Press, Istanbul Univ Rectorate, 2019) Mercan, Ugur; Gonen, Z. Burcin; Salkin, Hasan; Yalcin-Ulker, Gul Merve; Meral, Deniz Gokce; Ağız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery
Purpose The aim of this study is to compare effects of postoperative care agents; chlorhexidine, octenidine dihydrochloride and hyaluronic acid on human gingival fibroblasts' viability, proliferation, apoptosis and migration. Material and Methods After cell culturing; chlorhexidine, octenidine dihydrochloride and hyaluronic acid solutions were applied on cells and nothing was applied for control group. The cells were monitored to investigate cytotoxicity; the percentage of apoptotic, living and dead cells at the time of 24, 48, and 72 hours (h). A scratch wound assay was performed to detect cell migration and cells were monitored at baseline, at 24 and 48h. Results At 24h, chlorhexidine showed statistically lower percentage of total apoptotic cells' than octenidine dihydrochloride (p=0.049), hyaluronic acid (p=0.049) and control (p=0.049). At 48h, hyaluronic acid showed statistically lower percentage than chlorhexidine (p=0.049), and control (p=0.049). All agents were found to have statistically and significantly more cytotoxic than control. However, there was no difference between experimental groups for proliferation rate. Octenidine dihydrochloride showed statistically negative effects on cell migration than chlorhexidine and hyaluronic acid at 24h. Chlorhexidine and hyaluronic acid maintained migration ability of cells than octenidine dihydrochloride at 48h. Conclusion All agents have similar effects on cell behavior such as viability, apoptosis and cell proliferation. However, octenidine dihydrochloride showed statistically negative effects on migration ability than chlorhexidine and hyaluronic acid.
Citation Count: 0
Could Local Application of Hypoxia Inducible Factor 1-α Enhancer Deferoxamine Be Promising for Preventing of Medication-Related Osteonecrosis of the Jaw?
(Mdpi, 2023) Yalcin-Ulker, Gul Merve; Gunbatan, Murat; Duygu, Gonca; Soluk-Tekkesin, Merva; Ozcakir-Tomruk, Ceyda; Ağız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery
This experimental study investigates the prophylactic effect of deferoxamine (DFO) on medication-related osteonecrosis of the jaw (MRONJ). Thirty-six female Sprague Dawley rats received zoledronic acid (ZA) for eight weeks to create an osteonecrosis model. DFO was locally applied into the extraction sockets with gelatin sponge (GS) carriers to prevent MRONJ. The specimens were histopathologically and histomorphometrically evaluated. Hypoxia-inducible factor 1-alpha (HIF-1 alpha) protein levels in the extraction sockets were quantified. New bone formation rate differed significantly between groups (p = 0.005). Newly formed bone ratios in the extraction sockets did not differ significantly between the control group and the GS (p = 1), GS/DFO (p = 0.749), ZA (p = 0.105), ZA-GS (p = 0.474), and ZA-GS/DFO (p = 1) groups. While newly formed bone rates were higher in the ZA-GS and ZA-GS/DFO groups than in the ZA group, the differences were not significant. HIF-1 alpha levels differed significantly between groups (p < 0.001) and were significantly higher in the DFO and ZA-GS/DFO groups than in the control group (p = 0.001 and p = 0.004, respectively). While HIF-1 alpha levels were higher in the ZA-GS/DFO group than in the ZA group, the difference was not significant. While HIF-1 alpha protein levels and new bone formation rate were elevated in the DFO-treated group, the effect was not significant. Further large-scale studies are needed to understand DFO's preventative effects on MRONJ and the role of HIF-1 alpha in MRONJ pathogenesis.
Citation Count: 17
Tooth extractions in patients under antiresorptive therapy for osteoporosis: Primary closure of the extraction socket with a mucoperiosteal flap versus application of platelet-rich fibrin for the prevention of antiresorptive agent-related osteonecrosis of the jaw
(Churchill Livingstone, 2020) Poxleitner, Philipp; Steybe, David; Kroneberg, Philipp; Ermer, Michael Andreas; Yalcin-Ulker, Gul Merve; Schmelzeisen, Rainer; Voss, Pit Jacob; Ağız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery
Purpose: The aim of this study was to compare primary closure of the extraction socket to application of platelet-rich fibrin (PRF) without subsequent primary closure for the prevention of osteonecrosis of the jaw (ONJ) in patients administered antiresorptive therapy for osteoporosis. Materials and methods: Primary closure of the extraction socket was performed with a mucoperiosteal flap and two-layer suturing or PRF was inserted into the extraction socket without subsequent primary closure. In all patients, intra- and postoperative complications as well as the overall treatment outcome were recorded. Results: The patient sample consisted of 77 patients; primary closure with a mucoperiosteal flap was performed in 39 patients (group A), and application of PRF without subsequent primary closure was performed in 38 patients (group B). There were no statistically significant differences (p > 0.05) between the two groups in terms of age and gender, duration and type of antiresorptive therapy, teeth to be extracted (number, location and type) as well as comorbidities. No intraoperative complications occurred in either of the groups. Postoperative complications were found in 6 patients in group A and in one patient in group B. Analyzing risk factors for these complications, the highest OR (6.72 with p = 0.085 in univariate analysis; 12.81 with p = 0.052 in multivariate analysis) was found for the type of procedure (group A/group B). All patients had complete mucosal coverage without any signs of antiresorptive agent-related osteonecrosis of the jaw at the final control examination 90 days postoperatively. Conclusion: Based on the results of this study, the use of PRF can be recommended as a preventive measure in patients requiring tooth extractions while being under antiresorptive therapy for osteoporosis. (C) 2020 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
Citation Count: 7
A city-wide survey of dental students' opinions on undergraduate oral surgery teaching
(Wiley, 2020) Burdurlu, Muammer Cagri; Cabbar, Fatih; Dagasan, Volkan; Cukurova, Zeynep Gulen; Doganay, Ozge; Yalcin Ulker, Gul Merve; Ozcakir Tomruk, Ceyda; Ağız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery
Purpose This study aimed to carry out a city-wide survey to evaluate undergraduate students' opinions on their oral surgery training by measuring their self-confidence. Materials and Methods A cross-sectional survey of 383 3rd year, 412 4th year and 363 5th year undergraduate dental students from six dental schools in Istanbul with a mean age of 22.73 +/- 1.55 was conducted towards the end of the academic year. A web link to the questionnaire was sent to the contact person at the participating dental schools. The questionnaires were anonymously evaluated. Descriptive statistics were calculated, and Chi-square tests were performed to examine the data. A P-value of In total, 1158 responses were returned, representing 67% of the overall students in the 2018-2019 academic year. The male respondents were significantly more self-confident than females in the general aspects of surgical skills. More than half of the respondents (53%) felt confident in oral surgery knowledge to undertake independent practice. Although 5th year respondents felt more confident in the general aspect of the questionnaire, their ability of differentiation of odontogenic and non-odontogenic pain was lower than their counterparts. The majority (86%) of the participants disagreed that the only knowledge required for oral surgery was that of tooth and jaw anatomy. Conclusion This survey revealed perceived confidence in tooth and retained root extraction. The male respondents were found to be more self-confident. There is a need for improvement in surgical skills, recognition of malignancies and differentiation of the origin of the pain.
Citation Count: 0
Effect of Residual Bone Height and Implant Macro-Design on Primary Stability in Sinus Floor Elevation: An Ex Vivo Study
(Allen Press inc, 2023) Tokuc, Berkay; Cakir, Merve; Ulker, Gul Merve Yalcin; Geckili, Onur; Meral, Deniz Gokce; Kan, Bahadir; Ağız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery
The objective was to evaluate the influence of residual bone height (RBH) and implant macro -design on the primary stability (PS) of implants using a simultaneous sinus floor elevation (SFE) and implant insertion model. Fresh bovine rib samples that resembled type -IV density that were confirmed by computerized tomography were prepared to represent 4 groups of varying RBHs (3, 6, 9, 15 mm). To simulate simultaneous implant insertion with SFE, 120 implants in different macro -designs (group R: NobelReplace; group P: NobelParallel; group A: NobelActive, Nobel Biocare, Gothenburg, Sweden) were randomly inserted at RBHs of 3, 6, 9, and 15 mm in each rib. The implant stability quotient (ISQ) was measured immediately after implant insertion. RBH and implant macro -design have an impact on ISQ values (P < .001). ISQ values were the highest with RBH of 15 mm, followed by RBHs of 9, 6, and 3 mm. (P < .001). There was no statistically significant difference between different implant macro -designs at RBHs of 3 and 15 mm regarding ISQ values (P = .111, P = .551). ISQ values of group P were higher than those of group R and group A at an RBH of 6 mm (P = .049, P = .029). ISQ values were also higher in group P compared to group A at an RBH of 9 mm (P = .006). A higher PS may be expected in sites with higher RBH, regardless of the macro -design. In addition, cylindric implant design may enhance the PS at RBHs of 6 and 9 mm in simultaneous implant insertion with SFE.
Citation Count: 4
Antibiotic prescribing habits of the clinicians dealing with dental implant surgery in Turkey: a questionnaire study
(Springer Japan Kk, 2020) Yalcin-Ulker, Gul Merve; Cakir, Merve; Meral, Deniz Gokce; Ağız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery
Purpose Although various prophylactic and/or postoperative systemic antibiotic regimens have been suggested to minimize failure after dental implant placement and postoperative infection, the role of antibiotics in implant dentistry is still controversial. The purposes of this questionnaire study were to determine the current antibiotic prescribing habits of clinicians in conjunction with dental implant placement and to understand whether any consensus has been reached among implant surgery performing clinicians. Methods An electronic questionnaire was sent by electronic mail to all members of the Turkish Dental Society. The questions were related to whether antibiotics were routinely prescribed either pre- or/and postoperatively during routine dental implant placement. The respondents were also asked to specify their workplace and education. The results were analyzed using SPSS software. Descriptive and chi-square analyses were used to compare categorical data; Kruskal-Wallis test was used to compare the quantitative data by category. Results A total of 429 members responded to the questionnaire. The clinicians having more experience had a greater tendency to prescribe preoperative antibiotics (p< 0.001), but there was no statistically significant difference between the postoperative antibiotic prescription choice of the clinician according to the clinicians' experience (p> 0.05). A total of 175 of the clinicians preferred to prescribe preoperative antibiotics when there was systemic comorbidity; 99 of the clinicians preferred to prescribe antibiotics before every implant surgery. The aminopenicillins were the most commonly prescribed antibiotics by the clinicians. A total of 38.58% of the respondents (n= 130) who were prescribing preoperative antibiotics, 2000 mg aminopenicillin was given 1 h before the surgical procedure. Dentists and solo private practitioners were prescribing more preoperative antibiotics (p< 0,05). Conclusions There was no consensus among clinicians regarding the use of antibiotics in association with routine dental implant placement. Aminopenicillins were the most commonly prescribed antibiotics for both pre- and postoperatively. Furthermore, most of the antibiotic regimens being used are not in accordance with the current published data.
Citation Count: 0
İlaca Bağlı Çene Kemiği Osteonekrozu Modelinde Vasküler Endotelyal Büyüme Faktörü Ekspresyonunun İmmünhistokimyasal Olarak İncelenmesi
(2023) Aleyna KUCUR; Gül Merve YALÇIN ÜLKER; Alev CUMBUL; Ünal USLU; Ağız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery
Amaç: Bifosfonatlar (BP) kemikte anjiogenezis ve neovaskü- larizasyon olaylarında değişiklilere neden olarak, ilaca bağlı çene kemiği osteonekrozunda (İÇKON) bu durumun etkili ol- duğu düşünülmektedir. Pamidronat ve zoledronat (ZA) teda- vilerinin kan serumunda vasküler endotelyal büyüme faktörü (VEGF) seviyelerinde azalmaya sebep olduğu bilinmektedir. Bu deneysel çalışmanın amacı BP uygunlanmış sıçanlarda oluşturulan osteonekroz modelinde kemikte VEGF ekspres- yonu seviyesinin immünhistokimyasal yöntemler ile incelen- mesidir. Gereç ve Yöntem: Çalışmamızda osteonekroz modeli oluş- turmak amacı ile dişi Sprague-Dawley sıçanlara (n = 14) 8 hafta boyunca ZA enjeksiyonu yapılmıştır. Bu sürenin sonun- da sıçanların sol alt ikinci molarları çekilmiş ve sakrifikasyon öncesinde 8 hafta daha beklenmiştir.. İmmünhistokimyasal boyama sonrasında VEGF ekspresyonu, dağılım ve yoğunluk açısından değerlendirilmiştir. Enflamasyonun değerlendiril- mesi planlanan dokular da Hematokisilin&Eozin ile boyanmış- tır. Bulgular ve Sonuç: Kontrol grubu ile deney grubu (ZA) VEGF ekspresyonu açısından karşılaştırıldıklarında ZA grubunda dağılım ve yoğunluk kontrol grubuna göre anlamlı derece- de yüksektir (49,73 ± 1,222/13,27 ± 0,279; P < 0.001). Deney grubunda gözlenen enflamatuvar reaksiyon kontrol grubuna göre anlamlı derecede yüksek bulunmuştur (0/2,5 ± 0,58; p=0,003). ZA’nın kemik iyileşmesi ve enflamasyon gibi para- metrelere etkisini gösteren birçok deneysel ve klinik çalışma mevcuttur; fakat yazarların bilgisi dahilinde bu çalışma ZA’nın kemikte VEGF ekspresyonuna etkisinin incelendiği ilk de- neysel çalışmadır. ZA sebebi ile kemik dokusunda meydana gelen aşırı enflamatuvar reaksiyon sebebi ile kan serumdaki seviyelerinin aksine kemik dokusunda VEGF ekspresyonunun arttığı gözlenmiştir. Bu çalışmanın sonuçları ZA’nın kemikte VEGF ekspresyonunu aşırı artırarak kemik iyileşmesi üzerinde negatif bir etkisi olabileceğini göstermiştir. Bu yolağın anlaşı- labilmesi için daha detaylı moleküler çalışmalara ihtiyaç bu- lunmaktadır.
Citation Count: 14
Histopathological evaluation of the effect of systemic thymoquinone administration on healing of bone defects in rat tibia
(Taylor & Francis Ltd, 2017) Arslan, Ahmet Hamdi; Tomruk, Ceyda Ozcakir; Meydanli, Elif Guzel; Ozdemir, Ilkay; Capar, Gonca Duygu; Kutan, Esma; Ulker, Gul Merve Yalcin; Ağız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery
The aim of the present study was to assess the systemic effect of thymoquinone (TQ) on bone healing by starting TQ administration, either 40 days before, or on the day of the surgical procedure and continuing during the healing period of 28 days. Eighteen experimental rats were divided into three groups and defects were created in their tibias. The following procedures were performed for each group: Control group (C): No systemic drug administration (n D 6); Test group 1 (T1): Systemic TQ was administered daily starting 40 days before creation of the defect and additionally during the post-operative healing period of 28 days (n = 6); Test group 2 (T2): Systemic TQ was administered daily after creation of the defect and during the healing period of 28 days (n = 6). Quantitative measurement for new bone formation, osteoblast lining and semi-quantitative measurement of capillary intensities were examined and statistically analysed. There was a significant increase in the ratio of new bone per total defect area and new bone trabeculae lined by active osteoblasts in both test groups (T1 and T2) compared to control group (p < 0.05). However the difference between T1 and T2 was not statistically significant. TQ-administered groups also showed an increase in capillary intensity in the defect area compared to the control group (p < 0.05). Systemic administration of TQ either starting 40 days before or on the day of surgery accelerated new bone formation in a rat model and can be advocated as an adjunct to expedite bone healing.
Citation Count: 2
Use of Leukocyte-rich and Platelet-rich Fibrin (L-PRF) Adjunct to Surgical Debridement in the Treatment of Stage 2 and 3 Medication-Related Osteonecrosis of the Jaw
(Lippincott Williams & Wilkins, 2023) Yalcin-Ulker, Gul Merve; Duygu, Gonca; Tanan, Gamze; Cakir, Merve; Meral, Deniz Gokce; Ağız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery
Medication-related osteonecrosis of the jaw (MRONJ) is characterized by exposed necrotic bone persisting for more than 8 weeks in the maxillofacial region in patients using antiresorptive or antiangiogenetic drugs for several treatment options like bone metastasis or osteoporosis. There are several treatment options studied in scientific literature, and one of them with promising results is using platelet concentrates adjunct to surgical therapy. The aim of this study is to examine the therapeutic effect of leukocyte and platelet-rich fibrin (L-PRF) on patients with MRONJ. This 2-centered study investigated patients referred to oral and maxillofacial surgery departments of 2 university clinics between the years 2014 and 2020 with the diagnosis of MRONJ. Demographic data, the indication of the drug usage, drug type, duration, administration route, and systemic comorbidities of the patients were recorded. L-PRF was applied to 20 osteonecrotic lesions of 19 patients following surgical debridement. The male/female ratio was 5/14. Except 1 of the patients, all of the indications of medication were neoplasia-related. The mean follow-up period of patients was 27.9 & PLUSMN;9.2 months. Most common antirezorptive drug was zoledronate (84.2%). Complete resolution was observed in 16 necrosis sites (80%). It could be concluded that the use of L-PRF may represent an important adjunct in the surgical management of MRONJ.
Citation Count: 3
Preventive effect of doxycycline sponge against bisphosphonate-related osteonecrosis of the jaws: an animal study
(Taylor & Francis Ltd, 2016) Capar, Gonca Duygu; Sapmaz-Metin, Melike; Kutan, Esma; Tomruk, Ceyda Ozcakir; Yalcin, Gul Merve; Er, Nilay; Ozfidan, Gulnur Kizilay; Ağız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery
The aim of this study is to investigate the effect of doxycycline collagen sponge on bisphosphonate-related osteonecrosis of the jaw (BRONJ) and the level of serum biomarkers as an indicator of osteonecrosis. Twenty-four rats were divided into four groups. Animals in the control group were injected with saline and animals in Groups I, II and III were injected with zoledronate three times a week for eight weeks. After eight weeks, the following procedures were performed in each group. In Group I: extraction of maxillary first molar, in Group II: extraction of maxillary first molar and mucoperiosteal coverage was performed and in Group III: extraction of maxillary first molar and mucoperiosteal coverage with doxycycline collagen sponges was performed. At the end of 16 weeks, all animals were sacrificed. Serum collagen type I C-telopeptide (CTx), tartrate-resistant acid phosphatase (TRACP 5b) and alkaline phosphatase (ALP) levels' analysis, clinical examination, histological and histomorphometrical analysis were performed. As a result no significant difference in CTx, TRACP 5b and ALP levels was observed between groups. Complete mucosal healing was observed in all animals in the control group and 66.7% of animals in Group III. The necrotic bone area in Group III was significantly lower than the other groups (p < 0.01). Statistically significant difference was observed between groups in terms of detached osteoclast number (p < 0.01). In conclusion, local application of doxycycline could have a positive effect in reducing the risk of BRONJ in rats.

Yalçın Ülker, Gül Merve

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16

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