Gürkan, Alp

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Grkan A.
Alp GÜRKAN
Gürkan A.
Alp Gürkan, Gurkan A, Gürkan A, Gurkan Alp, Gürkan Alp
Gurkan, Alp
A., Gürkan
Gurkan Alp
Gurkan A.
Alp GURKAN
Alp Gürkan
Gurkan, A.
G̈rkan A.
Alp, Gürkan
Gürkan, A.
Gürkan Alp
Alp Gurkan
GURKAN Alp
GÜRKAN Alp
Gürkan, Alp
Gurkan A
Gürkan A
Job Title
Prof. Dr.
Email Address
alp.gurkan@okan.edu.tr
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WoS Researcher ID
Scholarly Output

18

Articles

16

Citation Count

109

Supervised Theses

0

Scholarly Output Search Results

Now showing 1 - 10 of 18
  • Article
    Citation Count: 1
    Clinicopathologic and Prognostic Features in Gallbladder Malignancies: Retrospective Analysis of 5206 Cases
    (Galenos Yayincilik, 2019) Ferhatoglu, Murat Ferhat; Senol, Kazim; Kivilcim, Taner; Kartal, Abdulcabbar; Gurkan, Alp; Genel Cerrahi / General Surgery
    Aim: Gallbladder cancer is the sixth most common cancer of the gastrointestinal system. Clinical presentation may not be distinguished from cholelithiasis or cholecystitis and most patients are diagnosed intraoperatively or in the postoperative histologic examination. In this study, we aimed to investigate the association of incidentally detected gallbladder cancer with gallbladder premalignant lesions, age, gender, ultrasonography features and gallbladder stones. Methods: Demographic and clinical characteristics and pathology results of 5206 patients who underwent cholecystectomy between January 2012 and December 2015 were evaluated retrospectively. Results: Three thousand eight hundred and eighty four (74.6%) patients were female. Pathologic reports showed pre-malignant and malignant lesions in 102 (1.95%) cases. Metaplasia was significantly more common in females, while no significant difference was found in development of dysplasia and cancer between genders. Gallbladder stone was found to be a risk factor for the development of metaplasia. Gallbladder wall thickening and advanced age are the most important risk factors for gallbladder cancer. Conclusion: Female gender and gallstone are important risk factors for the development of metaplasia. Advanced age, gallstone and gallbladder wall thickening on ultrasonography are the most important factors in the development cancer. Cholecystectomy should be kept in mind as the most effective method to prevent cancer development in elderly patients with gallbladder stones.
  • Conference Object
    Citation Count: 2
    Vascular variations of the kidney, retrospective analysis of computed tomography images of ninety-one laparoscopic donor nephrectomies, and comparison of computed tomography images with perioperative findings
    (Via Medica, 2020) Ferhatoglu, M. F.; Atli, E.; Gurkan, A.; Kebudi, A.; Genel Cerrahi / General Surgery
    Background: In this retrospective study, we aimed to determine the variations of kidney arteries and veins in kidney donor patients who underwent preoperative, computed tomography angiography (CTA). Materials and methods: We analysed kidney CTA findings of 91 donor nephrectomy patients operated from July 2016 through December 2017. Demographics, vascular diameters, abnormalities, numbers, branching variations, routing variations of arteries, and veins were assessed according to CTA images. We also compared the radiological findings with perioperative findings. Two radiologists evaluated CTA images, and the same surgical team performed all donor nephrectomies by laparoscopic approach. Results: Ninety-one of the 96 patients involved to study. Forty-six (50.5%) patients were female. Thirty-five (38.4%) of 91 cases had accessory arteries. Seven (7.6%) right, 1 (1.1%) left and 8 (8.7%) bilateral double hilar artery was observed on CTA. No statistically significant difference was observed in the evaluation of the side of accessory/polar arteries (p > 0.05), and in the evaluation of the distribution of arterial/venous variations according to perioperative findings (p > 0.05). However, in the evaluation of CTA images, we found that the diameter of the kidney artery and vein differed according to gender and side. Conclusions: The knowledge of the vascular variations of the kidney is essential for surgeons performing kidney transplantation. It is also essential for urologist and vascular surgeons. Incompatible with the literature, the right kidney has more vascular variations and, one kidney artery is found in the majority of Turkish kidney donor patients.
  • Conference Object
    Citation Count: 0
    Channels of Being Informed About Organ Transplantion Centers for Patients with End Stage Kidney Disease
    (Lippincott Williams & Wilkins, 2012) Gurkan, A.; Gulhan, Y. B.; Tilif, S.; Gul, Y.; Dheir, H.; Kacar, S. H.; Genel Cerrahi / General Surgery
    [No Abstract Available]
  • Article
    Citation Count: 0
    Effect of Visceral, Subcutaneous and Retroperitoneal Adipose Tissue on Renal Function After Living Donor Nephrectomy: A Retrospective Analysis of 69 Cases
    (Urol & Nephrol Res Ctr-unrc, 2020) Ferhatoglu, Murat Ferhat; Atli, Eray; Gurkan, Alp; Genel Cerrahi / General Surgery
    Purpose: Recent studies reported that the presence of metabolic syndrome is closely correlated with impaired kidney function after living donor nephrectomy. Since the measurement of body mass index cannot differentiate the amount of body adipose tissue from total body weight, body mass index is not a reliable parameter for determining metabolic syndrome. In the present study, we investigated the correlation between body adipose tissue and kidney function recovery following living donor nephrectomy. Materials and Methods: The patients who underwent living kidney donor nephrectomy consequently from July 2016 through December 2017 were enrolled in the study. We preoperatively measured the visceral (VAdT), retroperitoneal (RPAdT), and subcutaneous (SCAdT) adipose tissue volume by a computed tomography scan. Body mass index, adipose tissue measurements, and postoperative estimated glomerular filtration rate (eGFR) were evaluated. Results: The decrease between preoperative eGFR, and the first day, the first month and the sixth month eGFR after surgery were statistically significant (P = .001; P = .001; P = .001, respectively). The negative correlation between VAdT/SCAdT measurements and changes in eGFR at the first and the sixth postoperative month compared to preoperative eGFR were statistically significant (P = .049; P = .041, respectively). Additionally, RPAdT measurements and changes in eGFR at the first and the sixth postoperative month compared to preoperative eGFR (decreasing as RPAdT value increased) were statistically significant (P = .035; P = .026, respectively). Conclusion: According to a preoperative computed tomography scan, VAdT, RPAdT, and VAdT-to-SAdT ratio can predict impaired kidney function recovery. Furthermore, RPAdT measurement is a new variable to predict the impaired kidney function after living donor nephrectomy.
  • Article
    Citation Count: 1
    A Comparative Analysis of Once-daily and Twice-daily Formulation of Tacrolimus in De Novo Kidney Transplant Recipients
    (Kare Publ, 2021) Ferhatoglu, Murat Ferhat; Kartal, Abdulcabbar; Kivilcim, Taner; Filiz, Ali Ilker; Yildiz, Gursel; Gurkan, Alp; Genel Cerrahi / General Surgery
    Objectives: We aimed to compare the once-daily and twice-daily formulation of tacrolimus concerning the efficiency and effects on graft function in de novo kidney transplant patients. Methods: Twenty once-daily (TAC-OD) and twenty twice-daily (TAC-BID) tacrolimus administrated de novo kidney recipients who had received initial immunosuppressive therapy according to protocols at our institution (0.2 mg/kg of tacrolimus combined with 1000 milligrams of steroid taper plus 720 mg of mycophenolate and with 2.5mg/kg anti-thymocyte globulin) assessed concerning demographics, drug doses and blood concentration, and graft function. Results: The mean tacrolimus blood concentration measurements were higher in the TAC-OD group in the first sixty days after transplantation, and the TAC- OD group showed more blood concentration overshoots/fluctuations in the first 30 days of the treatment. The initial drug dose was significantly higher in the TAC-OD group than the TAC-BID group (p=0.04). There was no meaningful difference among groups according to graft function (creatinine measurements) (p>0.05). Conclusion: Between de novo kidney recipients, the new TAC-OD formulation presents a similar short-term efficacy profile as TACBID. However, a higher daily dosage of TAC-OD is needed to achieve similar blood concentrations in the early postoperative period.
  • Article
    Citation Count: 2
    Vascular variations of the kidney, retrospective analysis of computed tomography images of ninety-one laparoscopic donor nephrectomies, and comparison of computed tomography images with perioperative findings
    (Via Medica, 2020) Ferhatoğlu,M.F.; Atli,E.; Gürkan,A.; Kebudi,A.; Genel Cerrahi / General Surgery
    Background: In this retrospective study, we aimed to determine the variations of kidney arteries and veins in kidney donor patients who underwent preoperative, computed tomography angiography (CTA). Materials and methods: We analysed kidney CTA findings of 91 donor nephrectomy patients operated from July 2016 through December 2017. Demographics, vascular diameters, abnormalities, numbers, branching variations, routing variations of arteries, and veins were assessed according to CTA images. We also compared the radiological findings with perioperative findings. Two radiologists evaluated CTA images, and the same surgical team performed all donor nephrectomies by laparoscopic approach. Results: Ninety-one of the 96 patients involved to study. Forty-six (50.5%) patients were female. Thirty-five (38.4%) of 91 cases had accessory arteries. Seven (7.6%) right, 1 (1.1%) left and 8 (8.7%) bilateral double hilar artery was observed on CTA. No statistically significant difference was observed in the evaluation of the side of accessory/polar arteries (p > 0.05), and in the evaluation of the distribution of arterial/venous variations according to perioperative findings (p > 0.05). However, in the evaluation of CTA images, we found that the diameter of the kidney artery and vein differed according to gender and side. Conclusions: The knowledge of the vascular variations of the kidney is essential for surgeons performing kidney transplantation. It is also essential for urologist and vascular surgeons. Incompatible with the literature, the right kidney has more vascular variations and, one kidney artery is found in the majority of Turkish kidney donor patients. Copyright © 2020 Via Medica
  • Article
    Citation Count: 1
    Description and Outcomes of Three Different End-to-Side Microsurgical Techniques for the Anastomosis of Accessory Renal Artery With the Dominant Renal Artery in Kidney Transplantation
    (Elsevier Science inc, 2021) Colak, Hulya; Kivilcim, Taner; Unverdi, Omer Faruk; Yildiz, Gursel; Gurkan, Alp; Genel Cerrahi / General Surgery
    Background. In this study, we compared the outcomes of three different surgical microscope-assisted end-to-side anastomosis techniques between the dominant and accessory renal arteries during living donor kidney transplant. Methods. The demographics, serum creatinine levels, warm and cold ischemia times, rate of complications, and incidence of delayed graft function of 135 kidney recipients were analyzed according to the type of arterial anastomosis. Group A (n = 98) had one dominant renal artery (DRA) with one end-to-side anastomosis to the external iliac artery (EIA) using a surgical microscope. Group B (n = 17) had one DRA plus one accessory renal artery (ARA) with two separate end-to-side anastomoses to the EIA using a surgical microscope. Group C (n = 20) had one DRA with end-to-side anastomosis to the EIA and one ARA with an ex vivo on-bench end-to-side anastomosis to the DRA using a surgical microscope. Results. Compared with groups A and B, the cold ischemia time and the rate of delayed graft function were significantly higher in group C (P <= .001). At 6 months after transplant, group B demonstrated a higher creatinine value (2.40 +/- 3.41 mg/dL) than group A and group B (P = .032). Also, the decrease in creatinine at postoperative month 6 was limited in group B as compared with groups A and C. Conclusions. An end-to-side anastomosis between ARA (group B) and DRA (group A) of the kidney graft using a surgical microscope on the bench ex vivo results in superior outcomes. Single arterial anastomosis techniques are associated with a better function in a 6-month follow-up than two separate arterial anastomoses.
  • Article
    Citation Count: 0
    Global Effects of SARS-CoV-2 Era on Kidney Transplantation Activities: Analysis of WHO Data
    (Elsevier Science inc, 2022) Ferhatoglu, Murat Ferhat; Filiz, Ali Ilker; Sahin, Osman Z.; Gurkan, Alp; Genel Cerrahi / General Surgery
    Background. Uncertainty raises questions in kidney transplant during the severe acute respira-tory syndrome coronavirus 2 (SARS-CoV-2) pandemic regarding the recipient, the donor, and health care professionals. The pandemic not only has disrupted kidney transplanted patients but also has influenced transplant systems, donation chains, and timely and safe transplant surgeries. In the present study, we aimed to explore the global effects of the SARS-CoV-2 pandemic on kidney transplant.Methods. We collected transplantation statistics and SARS-CoV-2 pandemic data from the World Health Organization website on June 15, 2021. Spearman correlation analysis was applied to assess the strength of a monotonic relationship among quantitative variables. We also demon-strated the clinical characteristics of our kidney recipients with SARS-CoV-2 infection.Results. Comparison of the mean of global kidney transplantation statistics between 2010 and 2019 with 2020 statistics showed a significant decrease in kidney transplant from living donors (P < .001). From the beginning of the pandemic to June 15, 2021, 1 of the 43 kidney transplant patients we treated in our clinic died of SARS-CoV-2 infection after discharge. Two of the patients we transplanted and saw in follow-up before the pandemic died of SARS-CoV-2 infection.Conclusion. While the overall kidney transplant numbers have increased in the year to date, kidney transplants decreased drastically at the onset of the pandemic.
  • Article
    Citation Count: 0
    RENAL TRANSPLANTASYON HAZIRLIĞINDA MULTİ-DEDEKTÖR BİLGİSAYARLI TOMOGRAFİ ANJİYOGRAFİ İLE DONÖR ADAYLARININ DEĞERLENDİRİLMESİ
    (2024) Doğan, Demet; Gökce, Kağan; Kıvılcım, Taner; Gürkan, Alp; Genel Cerrahi / General Surgery
    Amaç: Böbrek donör adayı olarak başvuran kişilere uygulanan Multidedektörlü Bilgisayarlı Tomografi Anjiyografi (MDBTA) incelemesinde; kişinin donör olmasını engelleyebilecek veya cerrahi yaklaşımın değişmesine neden olabilecek renal ve ekstra renal bulgularımızı bildirmeyi amaçlamaktayız. Nakil öncesi donör değerlendirmesi için yapılan MDBTA incelemesinin ve sonuçlarının transplantasyon planlaması üzerindeki etkisinin altını çizmeyi hedeflemekteyiz. Yöntem: Çalışmamızda Ocak 2017 ile Kasım 2022 tarihleri arasında 496 böbrek verici adayına uygulanan renal MDBTA tetkiki retrospektif olarak değerlendirdi. Her iki böbreğin boyutu ve parankim kalınlığı ölçüldü. Her iki taraf renal arter ve venin çapı, sayıları, varyasyonları, anomalileri tespit edildi. Renal ve diğer batın içi patolojiler belirlendi. Tüm bu değerlendirmelerin sonucunda böbrek nakline engel olan bulgular saptandı. Böbrek nakli için donör adaylarının preoperatif değerlendirilmesinde MDBTA bulguları ve bu bulguların cerrahi yaklaşımı ne oranda etkilediği belirlendi. Bulgular: 496 böbrek verici adayının 273’ü erkek, 223’ü kadın idi. Verici adaylarının yaş aralığı 20-85 arasındaydı, yaş ortalaması ise 46,25±13,2 idi. 278 tanesi donör adayı olmuş, 218 aday çeşitli nedenler ile elenmiştir. Bunların 22 tanesi MDBTA’de tespit edilen bulgulara bağlı olarak donör olamamıştır. Nakile engel olan en sık MDBTA bulgusu ise bilateral böbrek taşı idi. Sonuç: Renal transplant öncesi nakile engel olacak batın içi renal ve ekstrarenal patolojilerin değerlendirilmesi oldukça önemlidir. Renal MDBTA; canlı böbrek donörlerinin minimal invaziv, hızlı ve doğru bir şekilde değerlendirilmesini sağlar. Bu nedenle MDBTA renal transplantasyon öncesi değerlendirmede kullanımı gittikçe yaygınlaşan bir görüntüleme yöntemidir.
  • Article
    Citation Count: 0
    Channels of being informed about kidney transplantation centers for patients with end stage kidney disease
    (Aves, 2012) Gurkan, Alp; Gulhan, Yildirim B.; Tilif, Suleyman; Gul, Yeliz; Genel Cerrahi / General Surgery
    Purpose: There are around 60,000 patients going through dialysis in our country. Although there are numerous successful transplant teams, the number of transplantations achieved has not reached the desired level. For this reason, kidney transplantation centers which keep increasing in number, have started different activities to inform these patients about the kidney transplantation. In our study, the patients having applied to three of the transplant centers in Istanbul were observed on how efficacious the activities were on the subjects. Patients and method: Patients having applied to the transplant centers in A (n: 1314), B (n: 27) and C (n: 229) hospitals, in the period between January 2, 2008 and December 31, 2010 were investigated by the organ transplant coordinators about how they were informed about these centers. In this study, it was observed that the patients got to know about the centers through dialysis centers stuffs, nephrologists, other patients, media and internet, etc. sources. We investigated on the differences these sources created in the different hospitals. In addition to these, on July 1, 2010; a website was established by A hospital with the same purpose. Also, the effect of this site in referring patients to the clinic was investigated. Results: We found out that patients were informed about organ transplantation centers from other patients, who have had organ transplantation (40.6%); dialysis centers (32.9%), media (9.6%), nephrologists (8.0%), internet (5.2%) and others (3.6%) (p=0.011). In A hospital, the mean average application number which was 34.6 patients/month went up to 44.5 patients/month after the establishment of the website. The website was found to be the only reason for the increase. Conclusion: Besides the mentioned factors; the internet which lately plays a great role in our daily life, also becomes an important guide for information for patients who want to have organ transplantation.