Gürkan, Alp
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Name Variants
Grkan A.
Alp GÜRKAN
Gürkan A.
Alp Gürkan, Gurkan A, Gürkan A, Gurkan Alp, Gürkan Alp
Gurkan, Alp
A., Gürkan
Gurkan Alp
Gurkan A.
Alp GURKAN
Alp Gürkan
Gurkan, A.
G̈rkan A.
Alp, Gürkan
Gürkan, A.
Gürkan Alp
Alp Gurkan
GURKAN Alp
GÜRKAN Alp
Gürkan, Alp
Gurkan A
Gürkan A
Alp GÜRKAN
Gürkan A.
Alp Gürkan, Gurkan A, Gürkan A, Gurkan Alp, Gürkan Alp
Gurkan, Alp
A., Gürkan
Gurkan Alp
Gurkan A.
Alp GURKAN
Alp Gürkan
Gurkan, A.
G̈rkan A.
Alp, Gürkan
Gürkan, A.
Gürkan Alp
Alp Gurkan
GURKAN Alp
GÜRKAN Alp
Gürkan, Alp
Gurkan A
Gürkan A
Job Title
Prof. Dr.
Email Address
alp.gurkan@okan.edu.tr
ORCID ID
Scopus Author ID
Turkish CoHE Profile ID
Google Scholar ID
WoS Researcher ID
Scholarly Output
18
Articles
16
Citation Count
109
Supervised Theses
0
18 results
Scholarly Output Search Results
Now showing 1 - 10 of 18
Conference Object Citation Count: 2Vascular variations of the kidney, retrospective analysis of computed tomography images of ninety-one laparoscopic donor nephrectomies, and comparison of computed tomography images with perioperative findings(Via Medica, 2020) Ferhatoglu, M. F.; Atli, E.; Gurkan, A.; Kebudi, A.; Genel Cerrahi / General SurgeryBackground: In this retrospective study, we aimed to determine the variations of kidney arteries and veins in kidney donor patients who underwent preoperative, computed tomography angiography (CTA). Materials and methods: We analysed kidney CTA findings of 91 donor nephrectomy patients operated from July 2016 through December 2017. Demographics, vascular diameters, abnormalities, numbers, branching variations, routing variations of arteries, and veins were assessed according to CTA images. We also compared the radiological findings with perioperative findings. Two radiologists evaluated CTA images, and the same surgical team performed all donor nephrectomies by laparoscopic approach. Results: Ninety-one of the 96 patients involved to study. Forty-six (50.5%) patients were female. Thirty-five (38.4%) of 91 cases had accessory arteries. Seven (7.6%) right, 1 (1.1%) left and 8 (8.7%) bilateral double hilar artery was observed on CTA. No statistically significant difference was observed in the evaluation of the side of accessory/polar arteries (p > 0.05), and in the evaluation of the distribution of arterial/venous variations according to perioperative findings (p > 0.05). However, in the evaluation of CTA images, we found that the diameter of the kidney artery and vein differed according to gender and side. Conclusions: The knowledge of the vascular variations of the kidney is essential for surgeons performing kidney transplantation. It is also essential for urologist and vascular surgeons. Incompatible with the literature, the right kidney has more vascular variations and, one kidney artery is found in the majority of Turkish kidney donor patients.Article Citation Count: 0Evaluation of the relationship between perioperative urine culture and postoperative urinary tract infections in renal transplant patients(2019) Murat Ferhat FERHATOĞLU; Ali İlker FİLİZ; Abut KEBUDİ; Abdülcabbar KARTAL; Alp GÜRKAN; Taner KIVILCIM; Gürsel YILDIZ; Genel Cerrahi / General SurgeryAim: The aim of the study was to determine the prevalence and risk factors of bacterial urinary tract infection (UTI) in patientsundergoing renal transplantation and to evaluate the possible bacterial agents that colonize the bladder in patients with or withoutmicturition beforehand.Material and Methods: A total of 89 renal transplant patients were included in the study. Demographic characteristics of the patientssuch as age and gender, as well as the presence of micturition before transplantation, clinical findings, urine culture, and agents thatshowed growth were all retrospectively analyzed and the relevant data were recorded.Results: Of the total 89 patients, 17 (19.10%) developed a urinary tract infection within 12 months after transplantation. Eight ofthese patients required hospitalization for treatment, while four had at least two infection episodes. Escherichia coli and Klebsiellapneumonia were the two most common causative agents. A comparison of the groups with and without UTI revealed that micturitionbefore transplantation was not a factor that affected the development of UTI (p > 0.05).Conclusion: Because UTI represents a severe problem for renal transplant patients, it must be evaluated in all patients. No correlationwas found between preoperative micturition and postoperative UTI.Conference Object Citation Count: 0Channels of Being Informed About Organ Transplantion Centers for Patients with End Stage Kidney Disease(Lippincott Williams & Wilkins, 2012) Gurkan, A.; Gulhan, Y. B.; Tilif, S.; Gul, Y.; Dheir, H.; Kacar, S. H.; Genel Cerrahi / General Surgery[No Abstract Available]Article Citation Count: 0Effect of Visceral, Subcutaneous and Retroperitoneal Adipose Tissue on Renal Function After Living Donor Nephrectomy: A Retrospective Analysis of 69 Cases(Urol & Nephrol Res Ctr-unrc, 2020) Ferhatoglu, Murat Ferhat; Atli, Eray; Gurkan, Alp; Genel Cerrahi / General SurgeryPurpose: Recent studies reported that the presence of metabolic syndrome is closely correlated with impaired kidney function after living donor nephrectomy. Since the measurement of body mass index cannot differentiate the amount of body adipose tissue from total body weight, body mass index is not a reliable parameter for determining metabolic syndrome. In the present study, we investigated the correlation between body adipose tissue and kidney function recovery following living donor nephrectomy. Materials and Methods: The patients who underwent living kidney donor nephrectomy consequently from July 2016 through December 2017 were enrolled in the study. We preoperatively measured the visceral (VAdT), retroperitoneal (RPAdT), and subcutaneous (SCAdT) adipose tissue volume by a computed tomography scan. Body mass index, adipose tissue measurements, and postoperative estimated glomerular filtration rate (eGFR) were evaluated. Results: The decrease between preoperative eGFR, and the first day, the first month and the sixth month eGFR after surgery were statistically significant (P = .001; P = .001; P = .001, respectively). The negative correlation between VAdT/SCAdT measurements and changes in eGFR at the first and the sixth postoperative month compared to preoperative eGFR were statistically significant (P = .049; P = .041, respectively). Additionally, RPAdT measurements and changes in eGFR at the first and the sixth postoperative month compared to preoperative eGFR (decreasing as RPAdT value increased) were statistically significant (P = .035; P = .026, respectively). Conclusion: According to a preoperative computed tomography scan, VAdT, RPAdT, and VAdT-to-SAdT ratio can predict impaired kidney function recovery. Furthermore, RPAdT measurement is a new variable to predict the impaired kidney function after living donor nephrectomy.Article Citation Count: 1A Comparative Analysis of Once-daily and Twice-daily Formulation of Tacrolimus in De Novo Kidney Transplant Recipients(Kare Publ, 2021) Ferhatoglu, Murat Ferhat; Kartal, Abdulcabbar; Kivilcim, Taner; Filiz, Ali Ilker; Yildiz, Gursel; Gurkan, Alp; Genel Cerrahi / General SurgeryObjectives: We aimed to compare the once-daily and twice-daily formulation of tacrolimus concerning the efficiency and effects on graft function in de novo kidney transplant patients. Methods: Twenty once-daily (TAC-OD) and twenty twice-daily (TAC-BID) tacrolimus administrated de novo kidney recipients who had received initial immunosuppressive therapy according to protocols at our institution (0.2 mg/kg of tacrolimus combined with 1000 milligrams of steroid taper plus 720 mg of mycophenolate and with 2.5mg/kg anti-thymocyte globulin) assessed concerning demographics, drug doses and blood concentration, and graft function. Results: The mean tacrolimus blood concentration measurements were higher in the TAC-OD group in the first sixty days after transplantation, and the TAC- OD group showed more blood concentration overshoots/fluctuations in the first 30 days of the treatment. The initial drug dose was significantly higher in the TAC-OD group than the TAC-BID group (p=0.04). There was no meaningful difference among groups according to graft function (creatinine measurements) (p>0.05). Conclusion: Between de novo kidney recipients, the new TAC-OD formulation presents a similar short-term efficacy profile as TACBID. However, a higher daily dosage of TAC-OD is needed to achieve similar blood concentrations in the early postoperative period.Article Citation Count: 2Vascular variations of the kidney, retrospective analysis of computed tomography images of ninety-one laparoscopic donor nephrectomies, and comparison of computed tomography images with perioperative findings(Via Medica, 2020) Ferhatoğlu,M.F.; Atli,E.; Gürkan,A.; Kebudi,A.; Genel Cerrahi / General SurgeryBackground: In this retrospective study, we aimed to determine the variations of kidney arteries and veins in kidney donor patients who underwent preoperative, computed tomography angiography (CTA). Materials and methods: We analysed kidney CTA findings of 91 donor nephrectomy patients operated from July 2016 through December 2017. Demographics, vascular diameters, abnormalities, numbers, branching variations, routing variations of arteries, and veins were assessed according to CTA images. We also compared the radiological findings with perioperative findings. Two radiologists evaluated CTA images, and the same surgical team performed all donor nephrectomies by laparoscopic approach. Results: Ninety-one of the 96 patients involved to study. Forty-six (50.5%) patients were female. Thirty-five (38.4%) of 91 cases had accessory arteries. Seven (7.6%) right, 1 (1.1%) left and 8 (8.7%) bilateral double hilar artery was observed on CTA. No statistically significant difference was observed in the evaluation of the side of accessory/polar arteries (p > 0.05), and in the evaluation of the distribution of arterial/venous variations according to perioperative findings (p > 0.05). However, in the evaluation of CTA images, we found that the diameter of the kidney artery and vein differed according to gender and side. Conclusions: The knowledge of the vascular variations of the kidney is essential for surgeons performing kidney transplantation. It is also essential for urologist and vascular surgeons. Incompatible with the literature, the right kidney has more vascular variations and, one kidney artery is found in the majority of Turkish kidney donor patients. Copyright © 2020 Via MedicaArticle Citation Count: 0Global Effects of SARS-CoV-2 Era on Kidney Transplantation Activities: Analysis of WHO Data(Elsevier Science inc, 2022) Ferhatoglu, Murat Ferhat; Filiz, Ali Ilker; Sahin, Osman Z.; Gurkan, Alp; Genel Cerrahi / General SurgeryBackground. Uncertainty raises questions in kidney transplant during the severe acute respira-tory syndrome coronavirus 2 (SARS-CoV-2) pandemic regarding the recipient, the donor, and health care professionals. The pandemic not only has disrupted kidney transplanted patients but also has influenced transplant systems, donation chains, and timely and safe transplant surgeries. In the present study, we aimed to explore the global effects of the SARS-CoV-2 pandemic on kidney transplant.Methods. We collected transplantation statistics and SARS-CoV-2 pandemic data from the World Health Organization website on June 15, 2021. Spearman correlation analysis was applied to assess the strength of a monotonic relationship among quantitative variables. We also demon-strated the clinical characteristics of our kidney recipients with SARS-CoV-2 infection.Results. Comparison of the mean of global kidney transplantation statistics between 2010 and 2019 with 2020 statistics showed a significant decrease in kidney transplant from living donors (P < .001). From the beginning of the pandemic to June 15, 2021, 1 of the 43 kidney transplant patients we treated in our clinic died of SARS-CoV-2 infection after discharge. Two of the patients we transplanted and saw in follow-up before the pandemic died of SARS-CoV-2 infection.Conclusion. While the overall kidney transplant numbers have increased in the year to date, kidney transplants decreased drastically at the onset of the pandemic.Article Citation Count: 2Retrospective Analysis of the first 100 Kidney Transplants at the Istanbul Okan University, Health Application and Research Center(Kare Publ, 2019) Ferhatoglu, Murat Ferhat; Kartal, Abdulcabbar; Kivilcim, Taner; Filiz, Ali Ilker; Kebudi, Abut; Gurkan, Alp; Genel Cerrahi / General SurgeryObjectives: The renal transplant program of Istanbul Okan University Hospital started in August 2017. Five cadaveric and 95 living donor kidney transplants have been performed for over 16 months. In this study, we aimed to share our experiences regarding kidney transplantation. Methods: In this study, a retrospective analysis of 100 patients who underwent kidney transplantation at the Istanbul Okan University over 16 months, the Health Application and Research Center was carried out. Patients' demographics, creatinine levels of donors and recipients, co-morbid conditions, postoperative complications, features of arterial anastomosis and arterial variations observed on computed tomography angiography of donor-patient were assessed. Results: Mean age of donor patients was 44.05 +/- 13.76 (18-71) years. All living donors had computed tomography angiography for assessment of the vascular structure of both kidneys. Accessory right kidney artery was the most dominant vascular variation (16.5%). The primary cause of chronic renal disease was diabetes mellitus (36.4%) and hypertension (15.6%). Mean warm and cold ischemia time was 1.82 +/- 0.44 (1-3) and 40.25 +/- 6.12 (31-57) minutes, respectively. The most observed postoperative complication was stenosis of ureter anastomosis (4.1%). End-to-end arterial anastomosis between renal and internal iliac arteries was the most preferred anastomosis (57.2%). Conclusion: Increasing kidney transplantation, which is the most appropriate treatment in terms of cost-effectiveness, will be beneficial for patient health and economy of the country.Article Citation Count: 1Description and Outcomes of Three Different End-to-Side Microsurgical Techniques for the Anastomosis of Accessory Renal Artery With the Dominant Renal Artery in Kidney Transplantation(Elsevier Science inc, 2021) Colak, Hulya; Kivilcim, Taner; Unverdi, Omer Faruk; Yildiz, Gursel; Gurkan, Alp; Genel Cerrahi / General SurgeryBackground. In this study, we compared the outcomes of three different surgical microscope-assisted end-to-side anastomosis techniques between the dominant and accessory renal arteries during living donor kidney transplant. Methods. The demographics, serum creatinine levels, warm and cold ischemia times, rate of complications, and incidence of delayed graft function of 135 kidney recipients were analyzed according to the type of arterial anastomosis. Group A (n = 98) had one dominant renal artery (DRA) with one end-to-side anastomosis to the external iliac artery (EIA) using a surgical microscope. Group B (n = 17) had one DRA plus one accessory renal artery (ARA) with two separate end-to-side anastomoses to the EIA using a surgical microscope. Group C (n = 20) had one DRA with end-to-side anastomosis to the EIA and one ARA with an ex vivo on-bench end-to-side anastomosis to the DRA using a surgical microscope. Results. Compared with groups A and B, the cold ischemia time and the rate of delayed graft function were significantly higher in group C (P <= .001). At 6 months after transplant, group B demonstrated a higher creatinine value (2.40 +/- 3.41 mg/dL) than group A and group B (P = .032). Also, the decrease in creatinine at postoperative month 6 was limited in group B as compared with groups A and C. Conclusions. An end-to-side anastomosis between ARA (group B) and DRA (group A) of the kidney graft using a surgical microscope on the bench ex vivo results in superior outcomes. Single arterial anastomosis techniques are associated with a better function in a 6-month follow-up than two separate arterial anastomoses.Article Citation Count: 1Clinicopathologic and Prognostic Features in Gallbladder Malignancies: Retrospective Analysis of 5206 Cases(Galenos Yayincilik, 2019) Ferhatoglu, Murat Ferhat; Senol, Kazim; Kivilcim, Taner; Kartal, Abdulcabbar; Gurkan, Alp; Genel Cerrahi / General SurgeryAim: Gallbladder cancer is the sixth most common cancer of the gastrointestinal system. Clinical presentation may not be distinguished from cholelithiasis or cholecystitis and most patients are diagnosed intraoperatively or in the postoperative histologic examination. In this study, we aimed to investigate the association of incidentally detected gallbladder cancer with gallbladder premalignant lesions, age, gender, ultrasonography features and gallbladder stones. Methods: Demographic and clinical characteristics and pathology results of 5206 patients who underwent cholecystectomy between January 2012 and December 2015 were evaluated retrospectively. Results: Three thousand eight hundred and eighty four (74.6%) patients were female. Pathologic reports showed pre-malignant and malignant lesions in 102 (1.95%) cases. Metaplasia was significantly more common in females, while no significant difference was found in development of dysplasia and cancer between genders. Gallbladder stone was found to be a risk factor for the development of metaplasia. Gallbladder wall thickening and advanced age are the most important risk factors for gallbladder cancer. Conclusion: Female gender and gallstone are important risk factors for the development of metaplasia. Advanced age, gallstone and gallbladder wall thickening on ultrasonography are the most important factors in the development cancer. Cholecystectomy should be kept in mind as the most effective method to prevent cancer development in elderly patients with gallbladder stones.
