Sheıkhvatan, Mehrdad

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Mehrdad Sheikhvatan
Mehrdad SHEIKHVATAN
Mehrdad Sheıkhvatan
Mehrdad, Sheıkhvatan
SHEIKHVATAN Mehrdad
SHEiKHVATAN Mehrdad
Sheikhvatan M.
Sheıkhvatan, Mehrdad
Mehrdad SHEiKHVATAN
Sheıkhvatan Mehrdad
M., Sheıkhvatan
Sheikhvatan Mehrdad
Sheikhvatan, Mehrdad
Sheikhvatan, M.
Sheıkhvatan, M.
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Dr.Öğr.Üyesi
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mehrdad.sheikhvatan@okan.edu.tr
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Scholarly Output

4

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2022 - 20244
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Now showing 1 - 4 of 4
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    Letter
    Citation Count: 1
    Causality Association Between COVID-19 Infection and Aortic Dissection
    (Turkish Society of Cardiology, 2022) Altuğ Tuncer,M.; Sheıkhvatan, Mehrdad; Sheikhvatan,M.; Toulany,M.; Tıbbi Biyoloji Anabilim Dalı / Department of Medical Biology
    [No abstract available]
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    Review
    Citation Count: 0
    Effect of deep brain stimulation on sexual dysfunction among patients who had Parkinson's disease: a systematic review and meta-analysis
    (Taylor & Francis Ltd, 2024) Sheıkhvatan, Mehrdad; Zafari, Rasa; Fathollahi, Mohammad Amin; Davari, Afshan; Sheikhvatan, Mehrdad; Ranji, Sara; Tafakhori, Abbas; Tıbbi Biyoloji Anabilim Dalı / Department of Medical Biology
    Background: Patients who have Parkinson's disease (PD) present several non-motor issues, such as sexual dysfunction. Deep brain stimulation (DBS) is a great treatment for PD and could affect both motor and non-motor symptoms of patients. Aim: The main goal of the current study is to evaluate the impact of DBS on the sexual dysfunction among patients with PD. Methods: Five databases (PubMed, Scopus, Embase, Web of Science, and Cochrane Library) were searched for records. Studies that measured the effect of DBS sexual function were included. The risk of bias assessment tool of non-randomized studies of interventions (ROBINS-I) was used to assess the quality of the included studies. The before and after data extraction and statistical analysis were performed using the Comprehensive Meta-analysis software (CMA) version 3.0. Result: Ten studies were included in the systematic review; six of them were eligible to perform a meta-analysis with a total sample size of 532 participants and a mean age of 62.21 +/- 1.59 years. All participants performed STN-DBS. The sexual function of participants after STN-DBS implantation significantly increased (SMD = -0.124, 95% CI: -0.209 to -0.038, P-value = 0.005). It also did not have any publication bias. Additionally, their quality of life mounts significantly (SMD = -0.712, 95% CI: -1.002 to -0.422, p-value <0.001). Conclusion: Our systematic review highlights the potential effect of STN-DBS on reducing the sexual dysfunction of patients with PD and boosting their quality of life.
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    Review
    Citation Count: 0
    Efficacy and safety of deep brain stimulation in drug resistance epilepsy: A systematic review and meta-analysis
    (Springer, 2024) Sheıkhvatan, Mehrdad; Javadnia, Parisa; Davari, Afshan; Sheikhvatan, Mehrdad; Ranji, Sara; Shafiee, Sajad; Tafakhori, Abbas; Tıbbi Biyoloji Anabilim Dalı / Department of Medical Biology
    In the context of drug-resistant epilepsy, deep brain stimulation (DBS) has received FDA approval. However, there have been reports of potential adverse effects, such as depression and memory impairment associated with DBS.This systematic review and meta-analysis aimed to investigate the impact of DBS on the quality of life (QoL), and seizure frequency of patients who had DRE, and assess its potential adverse events. The study followed PRISMA guidelines and thoroughly assessed databases, including Pubmed, Scopus, Embase, Web of Science, and the Cochrane Library, up to 31 July. Statistical analysis, fixed effect model analysis, performed by the Comprehensive Meta-analysis software (CMA) version 3.0. Additionally, Cochran's Q test was conducted to determine the statistical heterogeneity. The systematic review encompassed 54 studies, with 38 studies included in the subsequent meta-analysis. The total number of patients included in the studies was 999. The findings indicated a significant decrease in the mean seizure frequency of subjects following DBS (SMD: 0.609, 95% CI: 0.519 to 0.700, p-value < 0.001). Moreover, patients' QoL significantly improved after DBS (SMD: -0.442, 95% CI: -0.576 to -0.308, p-value < 0.001). The hippocampus displayed the most notable effect size among the different DBS targets. Subgroup analysis based on follow-up duration revealed increased DBS efficacy after two years. There are few reports of adverse events, such as insertional-related complications, infection, and neuropsychiatric complications, but the majority of these were temporary and non-fatal. DBS emerged as an effective and safe procedure for reducing seizure frequency and enhancing the quality of life in DRE patients, with minimal adverse events. Furthermore, the efficacy of DBS was observed to improve over time.
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    Review
    Citation Count: 0
    Comparative Efficacy and Safety of Therapeutic Strategies for Mirror Aneurysms: a Systematic Review and Meta-Analysis
    (Springer, 2024) Sheıkhvatan, Mehrdad; Bahadori, Amir Reza; Naghavi, Erfan; Kashan, Azadeh Imeni; Davari, Afshan; Sheikhvatan, Mehrdad; Ranji, Sara; Tıbbi Biyoloji Anabilim Dalı / Department of Medical Biology
    Mirror aneurysms are rare and pose therapeutic challenges, with both endovascular and microsurgical options available. Single-stage and two-stage procedures are employed, but the optimal strategy remains unclear. This systematic review and meta-analysis evaluate the efficacy and safety of different therapeutic strategies for managing mirror aneurysms. The study adhered to PRISMA guidelines and comprehensively analyzed data from multiple databases, including Pubmed, Scopus, Embase, Web of Science, and the Cochrane Library, up to 30th September 2024. Statistical analysis utilized the Comprehensive Meta-analysis (CMA) software version 3.0. This systematic review encompasses 42 studies, with 11 studies undergoing meta-analysis. The meta-analysis included 629 participants. Both microsurgical clipping and endovascular interventions achieved high rates of complete occlusion (RROC 1) (ES = 0.896; 95% CI: 0.840 to 0.931; P < 0.001) with low to moderate heterogeneity (I-2 = 46.46%). Favorable neurological outcomes (mRS <= 2) were significantly achieved among all patients (ES = 0.924; 95% CI: 0.891 to 0.948; P < 0.001) with low heterogeneity (I-2 = 15.52%). Subgroup analysis revealed that microsurgical clipping demonstrated superior occlusion rates and more consistent neurological outcomes compared to endovascular treatment. Also, complications were reported in seven studies (n = 492) and included cerebral infarction, hydrocephalus, and vasospasm. As well, mortality and recurrence were rare. Both microsurgical clipping and endovascular interventions are effective and safe for treating mirror aneurysms, with clipping showing superior occlusion rates and consistent outcomes. Single-stage procedures and unilateral craniotomy are associated with better neurological outcomes when feasible.