Kaya, Ayşe Demet

Name Variants

Ayşe Demet KAYA
KAYA Ayse Demet
Ayşe D. Kaya
Ayse Demet Kaya
A. D. Kaya
Ayşe Demet Kaya
A. D. KAYA
Ayşe Demet, Kaya
Kaya Ayse Demet
Kaya, Ayse Demet
Ayse Demet KAYA
Kaya Ayşe Demet
Ayse D. Kaya
Kaya, Ayşe Demet
Kaya, A.
Kaya, Demet
Kaya A.
Kaya, Ayşe
A. Demet Kaya
Kaya, Ayse
Kaya D.
KAYA Ayşe Demet
Kaya, D.
Kaya, Ayşe Demet
Kaya, Ayse Demet
Kaya, A. Demet
Kaya, Ayşe Demet
Kaya, Ayse Demet
Kaya, A. Demet

Job Title

Prof.Dr.

Email Address

demet.kaya@okan.edu.tr

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Scholarly Output

23

Articles

17

Citation Count

3

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0 Scholarly Output Search Results

Now showing 1 - 10 of 23

Citation Count: 0
TREATMENT SUCCESS WITH TIGECYCLINE IN COMBINATION IN A CRITICALY ILL BRUCELLOSIS PATIENT: A CASE REPORT
(Nobel Ilac, 2023) Yesilyurt, I. D. Murat; Kaya, Ayse Demet; Kurc, Mine Aydin; Tıbbi Mikrobiyoloji / Medical Microbiology
Neurobrucellosis is serious complication of Brucella infections and treatment options are quite controversial. Due to high relapse rates and treatment failure observed with monotherapy, a combined therapy is applied. In combination therapy, recently promising results are reported when tigecycline is combined with other antibacterial agents. Besides in-vitro studies, human case reports,-predominantly for severe and life-threatening infections-support treatment success. In this study, we are presenting a case of neurobrucellosis, who recieved a combination therapy including tigecycline, ceftriaxone and rifampicin and totally recovered with no sequela. Our case had the signs and symptoms suspecting of neurobrucellosis, but remained underdiagnosed and cardio/pulmonary arrest had occurred. After resuscitation the patient was hospitalized in the intensive care unit (ICU). Diagnosis of brucellosis was based on clinical features, culture and serological tests of blood and cerebrospinal fluid (CSF) samples, neuroimaging and confirmed by molecular methods. Tigecycline was used by intravenous (IV) route in combination with ceftriaxone and rifampicin, as the patient was mechanicaly ventilated and oral intake was by nasogastric (NG) tube. Risk of vomiting which would prevent doxycycline efficiency led us to apply this combination, to eliminate the risk in this critically ill patient. After observing significant improvement, the treatment was replaced with the oral treatment of rifampicin and doxycycline and terminated in six months. In conclusion, tigecycline seems to be a potential treatment option for brucellosis in combination with other drugs, particularly for specific patient groups, and severe and life threatening conditions related with brucellosis, who have limited alternative treatment options.
Citation Count: 0
Vulvovajinal Kandidiyazis: Risk Faktörleri ve İnfeksiyon Etkenlerinin Dağılımı
(2024) Arzu MALAK; Mine AYDIN KURÇ; Dumrul GÜLEN; Ayşe Demet KAYA; Nicel TAŞDEMİR; Gamze VAROL; Tıbbi Mikrobiyoloji / Medical Microbiology
Amaç: Dünyada yaygın görülen, milyonlarca kadının hayatını etkileyen ve anormal vajinal akıntının sık nedenlerinden olan vulvovajinal kandidiyazis (VVC)’in en önemli etkeni günümüze kadar Candida albicans iken, son yıllarda Non-albicans Candida (NAC) türlerinin sıklığı artmıştır. VVC’ da, birçok risk faktörünün de infeksiyon gelişimi ve tekrarlamasını etkilediği belirlenmiştir. Bu çalışmada; anormal vajinal akıntı yakınması olan hastalarda VVC sıklığı ve etkenlerinin belirlenerek, infeksiyon ile ilişkili risk faktörlerinin araştırılması amaçlanmıştır. Gereç ve Yöntemler: Anormal vajinal akıntı şikayeti olan 87 hastaya, sosyo-demografik özellikleri ve risk faktörleri olarak tanımlanan bağımsız değişkenleri içeren 26 soruluk anket uygulanmıştır. Toplanan vajinal sürüntü örneklerinin kültür ve mikroskopik incelemesi yapılarak, izolatlar klasik ve biyokimyasal testle identifiye edilmiştir. Bulgular: Hastaların %18,4’ünde Candida cinsi mantar üremesi saptanırken, gebelerde bu oran %60 olarak bulunmuştur. İnfeksiyon etkeni olarak izole edilen Candida’lardan %43,7 C. albicans, %37,5 C. glabrata, %12,5 C. krusei ve %6,3 C. parapsilosis olarak tanımlanmıştır. Hastaların %68,7’i tekrarlayan infeksiyon geçirdiğini bildirmiştir. Çalışmada VVC üremesini etkileyen tek faktör gebelik olarak saptanmış (p=0,041); VVC’i etkilemesi beklenen diğer bağımsız faktörler arasında anlamlı fark saptanmamıştır (p>0,05). Sonuç: Çalışmamız; VVC etiyolojisinde NAC türlerinin öneminin arttığını ve saptanan yüksek rekürrens oranları ile ilişkili olabileceğini göstermektedir. Bu bulgu VVC hastalarında ve özellikle de çalışmamızda risk faktörü olarak saptanmış gebelik döneminde, etkenlerin tür düzeyinde tanımlanmasının ve olası risk faktörlerinin bilinerek, kontrol altında tutulmasının önemini ortaya koymaktadır.
Citation Count: 1
Hemşirelik Öğrencilerinde Nazal Staphylococcus aureus Taşıyıcılığının Araştırılması
(2022) Kevser ATALIK; Aydın AYDINLI; Birsen YÜRÜGEN; Ülken Tunga BABAOĞLU; Deniz SERTEL ŞELALE; Harika DİNÇ; Ayşe Demet KAYA; Tıbbi Mikrobiyoloji / Medical Microbiology; Hemşirelik / Nursing
Amaç: Staphylococcus aureus ve Metisiline dirençli Staphylococcus aureus (MRSA) ile kolonize sağlık personeli ve sağlık alanında eğitim alan öğrenciler, hastane enfeksiyonları gelişimi açısından risk oluşturmaktadır.Nazal taşıyıcılığın belirlenmesi ve önlenmesi, enfeksiyon kontrolünde önem taşımaktadır. Bu çalışmada, hemşirelik öğrencilerinin klinik stajlara başlamadan ve staj döneminde aktif olarak sağlık kurumlarında çalışırken nazal S. aureus taşıyıcılık durumları araştırılmıştır. Gereç ve Yöntemler: Çalışmaya, 69’u birinci sınıfta, 60’ı ise üçüncü sınıfta eğitim görmekte olan toplam 129 hemşirelik öğrencisi dahil edilmiştir. Öğrencilerden alınan nazal sürüntü örnekleri koyun kanlı agar ve mannitol tuz agara ekilmiş ve bir gece inkübasyonu takiben, konvansiyonel yöntemler ile identifiye edilmiştir. Metisilin duyarlılığı disk difüzyon yöntemi ile belirlenmiştir. İstatistiki analizde Pearson Ki-Kare testi kullanılmış ve istatistiksel anlamlılık p
Citation Count: 0
Evaluation of The Effect of Different Polyetheretherketone Materials on Biofilm Formation: An in vitro Study
(Galenos Publ House, 2024) Kayaalti-Yuksek, Sibel; Atalik, Kevser; Karademir, Beguem; Saridag, Serkan; Kaya, Ayse Demet; Degirmenci, Kuebra; Tıbbi Mikrobiyoloji / Medical Microbiology; Protetik Diş Tedavisi / Prosthetic Dental Treatment; Periodontoloji / Periodontology
Objective: The aim of this in vitro study was to investigate microorganism adhesion and biofilm formation between pure and ceramic-reinforced polyetheretherketone (PEEK) materials. Methods: A total of 72 rectangular (8 x 8 x 4 mm) samples were prepared from pure-PEEK without filler and PEEK (Ceramicreinforced PEEK - bio high-performance polymer) containing 20% nano-ceramic filler. A profilometer contact surface measurement device was used to assess the surface roughness of the samples. PEEK groups (36 pure PEEK, 36 Ceramic-reinforced PEEK) were divided into 4 sub-groups of 9 according to the microorganism strains. Staphylococcus aureus [American Type Culture Collection (ATCC 29213)], Acinetobacter baumannii (ATCC 19606), Enterococcus faecalis (ATCC 29212), and Candida albicans (ATCC 10231) standard strains were used for microbiological analysis. Blocks were added to 24-well microplates containing suspensions of microorganisms and were incubated at 37 degrees C for 72 hours. Microplates were read at a wavelength of 490 nm using crystal violet. Results: No significant difference was determined between the PEEK groups in terms of surface roughness. No significant differences in biofilm formation of S. aureus , A. baummanii , E. faecalis , and C. albicans strains were found between the PEEK groups (p>0.05). In the pure -PEEK, the highest adhesion was recorded in S. aureus (p<0.001), and the lowest adhesion in C. albicans (p<0.001). In the ceramic -reinforced PEEK group, S. aureus and A. baummanii adhesions were observed more than E. faecalis and C. Albicans (p<0.001). Conclusion: The results of this investigation demonstrated no significant differences in the biofilm formation of different strains between PEEK materials. This was a preliminary study to define the biological characteristics of ceramic -reinforced PEEK. There is a need for further comparative and clinical studies on this subject.
Citation Count: 0
Association between Pityriasis Rosea (PR) and HHV-6/HHV-7 Infection: Importance of Sample Selection and Diagnostic Techniques
(Mdpi, 2024) Kurc, Mine Aydin; Erfan, Gamze; Kaya, Ayse Demet; Gulen, Dumrul; Oznur, Meltem; Yanik, Mehmet Emin; Tıbbi Mikrobiyoloji / Medical Microbiology; Tıbbi Mikrobiyoloji / Medical Microbiology
Recent studies have focused on the role of human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7) in PR etiology with varying results. In our study, with the approach that the discrepancy between the results may be related to the different samples and techniques used, we aimed to clarify the etiology by examining tissue and plasma samples using molecular methods and evaluating the results together with serological parameters. Skin biopsies and plasma samples of twenty-five PR patients were tested to detect HHV-6 and HHV-7 DNA using calibrated quantitative real-time polymerase chain reaction (CQ RT-PCR). IgG and IgM antibodies against HHV-6 and HHV-7 were tested by enzyme-linked immunosorbent assay and indirect immunofluorescence. Of the patient group, 64% were positive for HHV-6 IgG without IgM positivity. HHV-6 DNA was present in seven tissue and ten plasma samples. HHV-7 positivity was 100% and 12% for IgG and IgM antibodies, respectively. HHV-7 DNA was detected in four tissue samples and one plasma sample. Patients with HHV-7 DNA-positive plasma and tissue samples had also HHV-7 IgM antibodies. In conclusion, our results seem to support the role of HHV-6/HHV-7 in the etiology of PR. To clarify the etiology of PR and avoid confusion, the collection of different biological materials simultaneously and the usage of CQ RT-PCR as a diagnostic technique are recommended.
Citation Count: 11
Is the proprioceptive neuromuscular facilitation technique superior to Shaker exercises in swallowing rehabilitation?
(Springer, 2020) Sayaca, Cetin; Serel-Arslan, Selen; Sayaca, Nurhan; Demir, Numan; Somay, Goksel; Kaya, Defne; Karaduman, Ayse; Tıbbi Mikrobiyoloji / Medical Microbiology
Purpose This prospective study was planned to investigate whether the combined isotonic technique of proprioceptive neuromuscular facilitation (PNF) is superior to Shaker exercises in improving the function of swallowing muscles. Methods Fifty individuals (30 females and 20 males; mean age 68 +/- 3.89 years) with swallowing difficulties were separated into two groups randomly. The treatment groups were Shaker and PNF groups, which performed these exercises three times in a week for6 weeks. Swallowing difficulties were determined with the Turkish version of the eating assessment tool (T-EAT-10). The 100 ml-water swallow test was used to measure capacity, volume, and speed of swallowing. Contraction amplitude changes used as a universal measurement of motor unit activity during the muscle action were measured with superficial electromyography. Result After 6 weeks of exercise training, T-EAT-10 scores decreased in both groups (p < 0.001). Water swallowing capacity and volume improved in both groups (p < 0.001). There was no change in swallowing speed in both groups (p > 0.05). Maximal voluntary contraction values of suprahyoid muscles were higher in PNF than the Shaker group (p < 0.05). Conclusion Both the types of exercise can be used in the rehabilitation of swallowing difficulties. However, the PNF technique increased the contraction amplitude values that occur during maximum contraction more than the Shaker exercises. Different functional evaluations are needed to determine the effectiveness of PNF on swallowing difficulty.
Citation Count: 0
Distribution and antifungal susceptibility profiles of candida species isolated from dermatomycosis patients
(2024) Kurç, Mine Aydın; Kaya, Ayşe Demet; Erfan, Gamze; Albayrak, Şule; Tıbbi Mikrobiyoloji / Medical Microbiology
Aims: Superficial mycoses are the most common dermatological diseases worldwide, and the causes are becoming increasingly resistant to antifungal agents used in treatment. The aim of our study was to identify the yeast species causing superficial mycoses and determine their susceptibilities to some antifungal agents. Methods: Skin and nail scraping samples obtained from 726 patients with suspected superficial fungal infection were collected and examined by direct microscopy and culture. Isolates were identified by conventional methods and API ID32 C (Biomeriux, France) commercial kits. The minimum inhibitory concentrations (MIC) of isolates against itraconazole, miconazole, nystatin, and terbinafine antifungals were determined by microdilution method. Results: A total of 59 yeasts were isolated from the samples. The most frequently isolated species were Candida glabrata (n=31, 52.54%), Candida guillermondii (n=9, 15.25%), and Candida albicans (n=7, 11.86%). In terms of infection sites, the most common involvement was observed in the foot (n=39, 66.1%) and nails (n=16, 27.1%). In terms of their antifungal susceptibilities, the highest resistance was detected against terbinafine (35.6%) and itraconazole (33.9%). Multidrug resistance was observed among strains of the Candida species (n=17, 28.8%). Conclusion: The most striking results of this study can be summarized as high rates of Candida glabrata isolation, increase in resistance rates, and a prevalence of 28.8% multidrug resistance. This data once again emphasize the importance of isolation, identification, and antifungal susceptibility testing in the diagnosis and effective treatment of superficial mycoses.
Citation Count: 2
Do we really need to coat the novel silicone intranasal splints with antibiotics?
(W B Saunders Co-elsevier inc, 2016) Ciftci, Zafer; Kurc, Mine Aydin; Kaya, Ayse Demet; Saracoglu, Gamze Varol; Deniz, Mahmut; Gultekin, Erdogan; Tıbbi Mikrobiyoloji / Medical Microbiology; Tıbbi Mikrobiyoloji / Medical Microbiology
Purpose: The novel silicone intranasal splints are suggested to resist biofilm formation due to their surface characteristics. We aimed to ascertain the necessity of coating these splints with antibiotics to prevent splint associated infections, in vitro. Materials and methods: Pieces of Doyle II airway nasal splints made of medical grade silicone were divided into two test groups, treated with either (i) 0.2% nitrofurazone solution or (ii) 0.2% nitrofurazone containing ointment, and a control group, treated with (iii) 0.9% saline. Splint pieces were then incubated with Staphylococcus aureus solutions at 37 degrees C for 48 and 96 h. Following this, the splint pieces were incubated in 20 ml Mueller Hinton agar and appearing colonies were counted. Results: Following 48 and 96 h of incubation, the colonization rates in the saline group were significantly higher than the nitrofurazone ointment group (p < 0.001). The colonization rates in the liquid nitrofurazone group were significantly lower in comparison to the nitrofurazone ointment group (p < 0.001 and p = 0.019 respectively). Conclusions: The method of coating the splints with antibiotic was superior to using uncoated splints in terms of preventing S. aureus colonization. The rather smooth surfaces of the splints were insufficient to block bacterial colonization and coating them with antibiotics seems to be beneficial for the prevention of infections. (C) 2016 Elsevier Inc. All rights reserved.
Citation Count: 0
GÜVENLİ KAN İÇİN KİME GÜVENELİM? TEKİRDAĞ İLİNDE KIZILAY KAN BAĞIŞ MERKEZİ ÇALIŞMALARININ MİKROBİYOLOJİK AÇIDAN DEĞERLENDİRİLMESİ
(2017) Saraçoğlu, Gamze Varol; Kurç, Mine Aydın; Kaya, A. Demet; Saraçoğlu, Atilla; Tıbbi Mikrobiyoloji / Medical Microbiology
Amaç: Bu araştırmanın amacı, Tekirdağ İlinde Kızılay Kan Bağışı Merkezi'ne (KKBM) yapılan gönüllü kan bağışı başvurularını ve mikrobiyolojik test sonuçlarını değerlendirmektir.Gereç ve Yöntem: Kesitsel tipte olan araştırma KKBM' nin 2010 yılı kayıtlarının incelenmesini kapsamaktadır. Veriler rutin kayıt sistemindeki bilgilerden düzenlenerek elde edildi. Çalışmanın evrenini 2010 yılında KKBM'ne gönüllü kan bağışçısı olmak için başvuran 8451 kişi oluşturdu. Çalışmada tanımlayıcı istatistik yöntemleri kullanıldı. Karşılaştırmalı analizlerde Tek yönlü varyans analizi, Student t ve Chi-square testi uygulandı. Sonuçlar, %95 güven aralığında ve iki yönlü olarak değerlendirildi. Bulgular: 2010'da KKBM'ne 8451 gönüllü kan bağışı başvurusu yapıldı. Gönüllü kan bağışçısı olarak başvuran 8451 kişinin %82.3'ünün başvurusu kabul edildi (n=6952). Kabul edilmeyen kanların %17.6'sı (n=1489) geçici, %0.1'i (n=10) kesin ret tanısı aldı; alınan kanların % 0.3'ü (n=23) reaktif sonuç nedeniyle imha edildi. Kanların %1.11'inde (n=77) mikrobiyolojik tarama testleri pozitif bulundu. HBsAg pozitifliği %0.98, Anti-HCV pozitifliği %0.10 ve VDRL serolojik pozitifliği %0.03 bulundu. Anti-HIV pozitif kan saptanmadı. Sonuç: Çalışmamızda VDRL/RPR pozitifliği ülkemiz verileriyle benzer bulunurken, HBsAg ve Anti-HCV pozitifliğinin Türkiye geneline göre daha düşük olduğu belirlendi.
Citation Count: 4
Investigating the usage possibility of metal mono carboxylates(metal naphthenates) as antibacterial agent in textile applications
(inst Natl Cercetare-dezvoltare Textile Pielarie-bucuresti, 2014) Yildiz, Aylin; Oztas, Merve; Dumrul, Gulen; Yesilyurt, Murat; Atav, Riza; Agirgan, A. Ozgur; Kaya, A. Demet; Tıbbi Mikrobiyoloji / Medical Microbiology
In this study, it was aimed to produce a substance, which could be used as an antibacterial agent in textiles, from petroleum sub-products in order to extend the use of petroleum and petroleum sub-products in textiles. For this aim, complex compounds with copper, cobalt, nickel, zinc, and sodium, were produced. Then, those compounds were applied onto cotton fabric by padding process, and their antibacterial activities were evaluated according to the AATCC 147 agar diffusion test method. As a result of the trials, it was determined that best results were obtained against both gram-positive and gram-negative bacteria with copper mono carboxylate. Its activity was still present against Staphylococcus aureus and Escherichia coli after 3 washings and against Bacillus subtilis and Klebsiella pneumoniae after 10 washings.

Kaya, Ayşe Demet

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23

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17

Citation Count

3

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