The effects of a single high-dose injection of vitamin-D on healing of condylar fractures in osteoporotic rats

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dc.contributor.authorAkif TÜRER
dc.contributor.authorUğur MERCAN
dc.contributor.authorOsman KELAHMETOĞLU
dc.contributor.authorYonca Betil KABAK
dc.contributor.authorDeniz Gokce MERAL
dc.contributor.otherAğız,Diş ve Çene Cerrahisi / Oral, Dental and Maxillofacial Surgery
dc.date.accessioned2024-05-25T12:19:52Z
dc.date.available2024-05-25T12:19:52Z
dc.date.issued2019
dc.departmentOkan Universityen_US
dc.department-tempBülent Ecevit Üniversitesi, Diş Hekimliği Fakültesi, Ağız Diş Çene Hastalıkları ve Cerrahisi Anabilim Dalı, Zonguldak, Türkiye Okan Üniversitesi, Diş Hekimliği Fakültesi, Ağız Diş Çene Hastalıkları ve Cerrahisi Anabilim Dalı, İstanbul, Türkiye Bezmi Alem Üniversitesi, Tıp Fakültesi, Plastik ve Rekonstrüktif Cerrahi Anabilim Dalı, İstanbul, Türkiye Ondokuz Mayıs Üniversitesi, Veteriner Fakültesi, Patoloji Anabilim Dalı, Samsun, Türkiye Okan Üniversitesi, Diş Hekimliği Fakültesi, Ağız Diş Çene Hastalıkları ve Cerrahisi Anabilim Dalı, İstanbul, Türkiyeen_US
dc.description.abstractAim: In this study we have tried to show the effects of a singlehigh-dose ınjection of vitamin d on healing of condylar fractures in osteoporotic rats.Materials and method: This study included sixteen femalewistar rats. All rats were overiectomized. Osteoporotic ratswere randomly divided into two groups of eight animals/group. Group D animals received a single high dose of vitamin D (50.000 IU/kg) intraperitoneally and group C (control)animals received saline (0.05 mL) intraperitoneally. All injections were given immediately after condylar fracture. All ratswere euthanized after 28 days, examined histopathologicaland immunohistochemical.Results: Histopathological and immunohistochemical evaluations were done. Histopathological scores between groupD and C were found statistically significant. TGFβ1 and osteopentin levels in group D were found higher than group C.Conclusion: We have determined that a single high-dose injection of vitamin D given immediately after surgery increasedTGFβ and osteopontin levels and enhanced new bone formation at condylar fractures of osteoporotic rats.en_US
dc.identifier.citation0
dc.identifier.doi10.5505/yeditepe.2019.83792
dc.identifier.endpage76en_US
dc.identifier.issn2458-9586
dc.identifier.issue1en_US
dc.identifier.startpage70en_US
dc.identifier.trdizinid312179
dc.identifier.urihttps://doi.org/10.5505/yeditepe.2019.83792
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/312179/the-effects-of-a-single-high-dose-injection-of-vitamin-d-on-healing-of-condylar-fractures-in-osteoporotic-rats
dc.identifier.urihttps://hdl.handle.net/20.500.14517/1847
dc.identifier.volume15en_US
dc.institutionauthorMeral, Deniz Gökçe
dc.institutionauthorMeral, Deniz Gökçe
dc.language.isoen
dc.relation.ispartof7tepe Kliniken_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[Fen > Diş Hekimliği > Diş Hekimliği]en_US
dc.titleThe effects of a single high-dose injection of vitamin-D on healing of condylar fractures in osteoporotic ratsen_US
dc.typeArticleen_US
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery569f6281-7cf0-4d81-8f8d-887f1e3d4a15
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