ASSOCIATION BETWEEN LEFT ATRIAL APPENDAGE THROMBUS FORMATION AND MONOCYTE/HDL RATIO IN PATIENTS WITH ACUTE ISCHEMIC STROKE

Abstract

Objective: There is an apparent link between thrombus formation and inflammation. Monocyte/high density lipoprotein ratio has been determined as an inflammatory marker and associated with many cardiovascular disorders like coronary artery disease, acute coronary stent thrombus, coronary thrombus burden and atrial fibrillation. The aim of this study was to clarify the correlation between Monocyte/high density lipoprotein ratio and left atrial appendage thrombus formation in individuals who have suffered from an acute ischemic cerebral infarction. Methods: The study retrospectively included a total of 69 patients who had been diagnosed with acute ischemic cerebral infarction. The patients’ demographic, clinical, and echocardiographic information were gathered from their records in a retrospective manner. Monocyte/high density lipoprotein ratio and neutrophil/lymphocyte ratio were calculated from admission laboratory data. Results: Thirteen patients had a LAATF (11 male; 64±14.5 years); 14 patients had spontaneous echo contrast stage 3 or 4 (11 male; 62.3±9.7 years) and 42 patients (29 males; 61.0±11.1 years) did not have left atrial appendage thrombus formation or SEC. With the exception of atrial fibrillation, the baseline demographic and clinical characteristics of the three groups were similar (p<0.001). Further, monocytes were significantly lower in the thrombus negative group compared to other groups (p<0.001). MHR was different in all three groups (p<0.001). This parameter was significantly increased in patients with left atrial appendage thrombus formation and spontaneous echo contrast findings. Conclusion: Our study showed that an increased MHR is associated with left atrial appendage thrombus formation.