Antioxidant Activity, Chemical Composition, and Therapeutic Activity of Essential Oils From Certain Lamiaceae Species in Türkiye

dc.authorwosid Dumlupınar, Berrak/Hir-1759-2022
dc.authorwosid Seker Karatoprak, Gokce/Aar-4229-2020
dc.contributor.author Goksu Surucu, Canan
dc.contributor.author Dumlupinar, Berrak
dc.contributor.author Gurbuz, Burcak
dc.contributor.author Seker Karatoprak, Gokce
dc.contributor.author Bahtiyarca, Reyhan
dc.contributor.author Ilgun, Selen
dc.date.accessioned 2025-03-15T20:26:48Z
dc.date.available 2025-03-15T20:26:48Z
dc.date.issued 2025
dc.department Okan University en_US
dc.department-temp Field Crops Cent Res Inst, Plant Based Food Res Ctr, Sehit Cem Ersever St 11, TR-06170 Yenimahalle, Ankara, Turkiye; [Dumlupinar, Berrak] Istanbul Okan Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-34959 Tuzla, Istanbul, Turkiye; [Gurbuz, Burcak] Marmara Univ, Fac Pharm, Dept Pharmaceut Microbiol, MU Recep Tayyip Erdogan Social Complex,Basibuyuk R, Basibuyuk, Ankara, Turkiye; [Seker Karatoprak, Gokce] Erciyes Univ, Fac Pharm, Dept Pharmacognosy, TR-38039 Kayseri, Turkiye; [Bahtiyarca, Reyhan] Field Crops Cent Res Inst, Dept Breeding, Sehit Cem Ersever St 11, TR-06170 Yenimahalle, Ankara, Turkiye; [Ilgun, Selen] Erciyes Univ, Fac Pharm, Dept Pharmaceut Bot, TR-38039 Kayseri, Turkiye en_US
dc.description.abstract The study examined the antioxidant, antimicrobial, and potential anticancer properties of lavandin (Lavandula x intermedia 'Grosso'), oregano (Origanum vulgare 'Ulu & gbreve; Bey'), and sage (Salvia officinalis 'Beyhekim') essential oils (EOs). Chemical analysis revealed that oregano is rich in carvacrol (81.23%), cymene (5.51%), and 18-cineole (2.13%). Sage contains notable quantities of alpha-thujone (17.47%), camphor (13.59%), and borneol (12.14%). Lavandin is predominantly composed of linalool (41.10%), linalyl acetate (16.66%), and camphor (10.01%). The antimicrobial tests demonstrated that lavandin EOs exhibited a high inhibition rate of 90.77% at 1000 pg/mL, which subsequently decreased with lower concentrations. The oregano essential oils demonstrated robust antimicrobial activity across all concentrations, with a 10.97% inhibition rate observed even at the lowest concentration. The sage EOs exhibited a rapid decline in antimicrobial activity, reaching 4.97% at the lowest concentration. Both the DPPH and ABTS assays demonstrated that the antioxidant capacity of the essential oils was concentration-dependent. The cytotoxicity values of oregano essential oil were 35.58 at 50 pg/mL, 32.39 at 25 pg/mL, and 30.92 at 12.5 pg/mL. Similar cytotoxicity results were observed for sage and lavandin essential oils. These findings indicate that plant essential oils exert a dose-dependent cytotoxic effect on cell growth, significantly inhibiting cells at high concentrations. The research indicates that essential oils derived from Lamiaceae plants exhibit robust antimicrobial effects against a range of pathogens, suggesting potential applications as alternative therapies for specific microbial infections, comparable to ciprofloxacin at certain concentrations. en_US
dc.description.woscitationindex Emerging Sources Citation Index
dc.identifier.citation 0
dc.identifier.doi 10.12991/jrespharm.1626231
dc.identifier.endpage 51 en_US
dc.identifier.issn 2630-6344
dc.identifier.issue 1 en_US
dc.identifier.scopusquality Q4
dc.identifier.startpage 30 en_US
dc.identifier.uri https://doi.org/10.12991/jrespharm.1626231
dc.identifier.volume 29 en_US
dc.identifier.wos WOS:001489648200004
dc.identifier.wosquality N/A
dc.language.iso en en_US
dc.publisher Marmara Univ, Fac Pharmacy en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Origanum Vulgare Subs. Hirtum en_US
dc.subject Salvia Officinalis L. en_US
dc.subject Lavandula X Intermedia en_US
dc.subject Antioxidant en_US
dc.subject Antimicrobial en_US
dc.subject Cytotoxicity en_US
dc.title Antioxidant Activity, Chemical Composition, and Therapeutic Activity of Essential Oils From Certain Lamiaceae Species in Türkiye en_US
dc.type Article en_US

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