Endoscopic botulinium toxin-A application in the treatment of obesity: The effect of dose and application area on treatment success

dc.contributor.author Ismail OZSAN
dc.contributor.author Ahmet Yekta TUZUN
dc.date.accessioned 2024-05-25T12:22:06Z
dc.date.available 2024-05-25T12:22:06Z
dc.date.issued 2023
dc.department Okan University en_US
dc.department-temp Okan Üniversitesi, Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, İstanbul, Türkiye İzmir Ekonomi Üniversitesi, Medicalpoint Hastanesi, Gastroenteroloji Anabilim Dalı, İzmir, Türkiye en_US
dc.description.abstract Aim: In this study, it was aimed to examine the effect of dose and region on the effectiveness of Endoscopic botulinum toxin A application in the fight against obesity. Materials and Methods: A total of 446 patients who applied to our clinic with the complaint of weight were included in the study. Endoscopic botulinum toxin A was administered at doses of 300 U (n=74), 400 U (n=172) and 500 U (n=200) according to the weight and Body Mass Index (BMI) values of the patients. Patients were divided into three groups in the Preploric, Cardia and Fundus regions, after 125 U of Endoscopic Botulinum toxin A application to each region, and 125 U application to one region. Results: Initial BMI, weight difference, last BMI and BMI differences were statistically significant between patient groups according to dose and area (p=0.000). All BMI differences between paired dose and area groups were statistically significant (p=0.000). BMI difference was significantly correlated with gender (r=0.108; p=0.023), Initial BMI (r=0.266; p=0.000), weight (r=0.219; p=0.000), dose (r=0.834; p=0.000), and area (r=0.200; p=0.000). Effects of initial BMI (B=0.031; p=0.031), dose (B=1.423; p=0.000) and area (B=0.316; p=0.000) on BMI difference were statistically significant. Conclusion: Optimum results are obtained in the application of fundus region with a density of 500 U in total, but at levels or values below this, the results may not be effective. Weight loss with the Endoscopic botulinium toxin-A method with the appropriate dose and area is an effective and usable method in the fight against obesity. en_US
dc.identifier.citationcount 0
dc.identifier.doi 10.5455/annalsmedres.2023.08.198
dc.identifier.endpage 1105 en_US
dc.identifier.issn 2636-7688
dc.identifier.issue 9 en_US
dc.identifier.startpage 1100 en_US
dc.identifier.trdizinid 1205588
dc.identifier.uri https://doi.org/10.5455/annalsmedres.2023.08.198
dc.identifier.uri https://search.trdizin.gov.tr/tr/yayin/detay/1205588/endoscopic-botulinium-toxin-a-application-in-the-treatment-of-obesity-the-effect-of-dose-and-application-area-on-treatment-success
dc.identifier.uri https://hdl.handle.net/20.500.14517/2064
dc.identifier.volume 30 en_US
dc.language.iso en
dc.relation.ispartof Annals of Medical Research en_US
dc.relation.publicationcategory Diğer en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.title Endoscopic botulinium toxin-A application in the treatment of obesity: The effect of dose and application area on treatment success en_US
dc.type Article en_US

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