Evaluation of the protective effects of folic acid on the lung exposed to 900-MHZ electromagnetic field: A stereological and histopathological study

dc.authorscopusid 55899813400
dc.authorscopusid 57741734000
dc.authorscopusid 15063935100
dc.contributor.author Tüfekçi,K.K.
dc.contributor.author Bakirhan,E.G.
dc.contributor.author Altunkaynak,B.Z.
dc.date.accessioned 2024-05-25T12:18:12Z
dc.date.available 2024-05-25T12:18:12Z
dc.date.issued 2022
dc.department Okan University en_US
dc.department-temp Tüfekçi K.K., Department of Histology and Embryology, Faculty of Medicine, Kastamonu University, Kastamonu, Turkey; Bakirhan E.G., Department Histology and Embryology, Faculty of Medicine, Adiyaman University, Adiyaman, Turkey; Altunkaynak B.Z., Department of Histology and Embryology, Faculty of Medicine, Okan University, Istanbul, Turkey en_US
dc.description.abstract There is strong scientific evidence that radio frequency (RF) radiation is harmful to life. Exposure to radiation may cause lung toxicity and respiratory disorders. Folic acid (FA) is one of the powerful antioxidants that minimize oxidative stress in the biological system. In this study, we evaluated the effectiveness of the FA against the EMF-induced potential negative effects on the lung. Twenty-four male Wistar albino rats were divided into the four groups; control group (Cont), electromagnetic field group (EMF), FA treated group (FA), and electromagnetic field exposure + FA treated group (EFA). After the routine histological procedures, volumes of the alveoli, bronchioles and blood vessels have been estimated by the Cavalieri principle. It was found that a significant decrease in the mean volume of alveoli, bronchioles and blood vessels in EMF group in comparison of the Cont group (p<0.01). Besides this, histopathological analysis demonstrated that there was impaired lung structure, shrunken alveoli, and increased thickness of the alveolar wall in the EMF group sections. In the EFA group, significant protective effects were observed in the structures volumes and histopathology (p<0.01). These findings corresponded with the antioxidant effect of FA treatment. Our results suggest that FA protected alveoli, bronchioles, and blood vessels against EMF-induced lung injury. Thus FA has the potential to be a therapeutic agent. © 2022 Ondokuz Mayis Universitesi. All rights reserved. en_US
dc.description.sponsorship Ondokuz Mayis Üniversitesi en_US
dc.identifier.citationcount 1
dc.identifier.doi 10.52142/omujecm.39.1.40
dc.identifier.endpage 209 en_US
dc.identifier.issn 1309-4483
dc.identifier.issue 1 en_US
dc.identifier.scopus 2-s2.0-85131964366
dc.identifier.scopusquality Q4
dc.identifier.startpage 204 en_US
dc.identifier.uri https://doi.org/10.52142/omujecm.39.1.40
dc.identifier.uri https://hdl.handle.net/20.500.14517/1662
dc.identifier.volume 39 en_US
dc.language.iso en
dc.publisher Ondokuz Mayis Universitesi en_US
dc.relation.ispartof Journal of Experimental and Clinical Medicine (Turkey) en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 1
dc.subject antioxidant en_US
dc.subject Cavalieri Principle en_US
dc.subject electromagnetic fields en_US
dc.subject folic acid en_US
dc.subject lung injury en_US
dc.subject stereology en_US
dc.title Evaluation of the protective effects of folic acid on the lung exposed to 900-MHZ electromagnetic field: A stereological and histopathological study en_US
dc.type Article en_US

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