Prenatal diclofenac sodium exposure and newborn testis: Histomorphometric, light and electron microscopic evaluation

dc.authorscopusid 21735288700
dc.authorscopusid 24511885800
dc.authorscopusid 57195678013
dc.authorscopusid 57054834700
dc.authorscopusid 26425788700
dc.authorscopusid 7403238396
dc.contributor.author Ulkay,M.B.
dc.contributor.author Aktaş,A.
dc.contributor.author Alkan,I.
dc.contributor.author Kaplan,A.A.
dc.contributor.author Deniz,Ö.G.
dc.contributor.author Kaplan,S.
dc.date.accessioned 2024-10-15T20:23:25Z
dc.date.available 2024-10-15T20:23:25Z
dc.date.issued 2021
dc.department Okan University en_US
dc.department-temp Ulkay M.B., Department of Histology and Embryology, Faculty of Veterinary, I˙stanbul University-Cerrahpaşa, I˙stanbul, Turkey; Aktaş A., Department of Histology and Embryology, Faculty of Veterinary, I˙stanbul University-Cerrahpaşa, I˙stanbul, Turkey; Alkan I., Department of Histology and Embryology, Faculty of Medicine, I˙stanbul Okan University, I˙stanbul, Turkey; Kaplan A.A., Department of Histology and Embryology, Faculty of Medicine, I˙stanbul Medipol University, I˙stanbul, Turkey; Deniz Ö.G., Department of Histology and Embryology, Faculty of Medicine, Bolu Abant I˙zzet Baysal University, Bolu, Turkey; Kaplan S., Department of Histology and Embryology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey en_US
dc.description.abstract Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used as analgesic with anti-inflammatory and antioxidant effects. Their widespread used and because of its toxic effects led to many studies to be done on it. Diclofenac sodium (DS) is the most commonly used a NSAID and it is used orally or topically. Many studies on the effects of DS on the reproductive system have shown that DS can cause infertility by means of various reasons. The effects of DS on the male reproductive system can be explained as impairment in secretion of the male endocrine system and formation of new spermatogonium, Sertoli and Leydig cells in the testicle. While DS causes a decrease in gonadotropin releasing hormone (GnRH) and testosterone levels, it may create a significant increase in prolactin level. However, several studies have shown that weights of the testes, epididymis, ventral prostate, and seminal vesicles, sperm count, sperm density, sperm motility, and testicular cell populations were seriously decreased by DS exposure. In this chapter, morphological and endocrinological effects of prenatal/postnatal DS exposure on the male reproductive system and fixation methods that can be used for toxicological studies of the male reproductive system will be evaluated. © 2021 by Nova Science Publishers, Inc. All rights reserved. en_US
dc.identifier.citationcount 0
dc.identifier.endpage 455 en_US
dc.identifier.isbn 978-153619215-5
dc.identifier.isbn 978-153619128-8
dc.identifier.scopus 2-s2.0-85152404748
dc.identifier.startpage 437 en_US
dc.identifier.uri https://hdl.handle.net/20.500.14517/6863
dc.language.iso en
dc.publisher Nova Science Publishers, Inc. en_US
dc.relation.ispartof A Comprehensive Guide to Non-Steroidal Anti-Inflammatory Drugs en_US
dc.relation.publicationcategory Kitap Bölümü - Uluslararası en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 0
dc.subject Diclofenac sodium en_US
dc.subject Non-steroidal anti-inflammatory drugs en_US
dc.subject Spermatogenesis en_US
dc.subject Spermiogenesis en_US
dc.subject Testis en_US
dc.title Prenatal diclofenac sodium exposure and newborn testis: Histomorphometric, light and electron microscopic evaluation en_US
dc.type Book Part en_US

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