Investigation of therapeutic effect of Saccharomyces boulardii and translocation in immunosuppressed rats infected with Shigella sonnei

dc.contributor.author Ayşe Demet KAYA
dc.contributor.author Mustafa BEHÇET
dc.date.accessioned 2024-05-25T12:20:33Z
dc.date.available 2024-05-25T12:20:33Z
dc.date.issued 2020
dc.department Okan University en_US
dc.department-temp Okan Üniversitesi, Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, İstanbul, Türkiye Bolu Abant İzzet Baysal Üniversitesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Bolu, Türkiye en_US
dc.description.abstract Aim: To investigate the therapeutic effects of Saccharomyces boulardii (S. boulardii) and detectblood and tissue penetrations of S. boulardii and Shigella sonnei (S. sonnei) in immunosuppressedrats infected with S. sonnei.Methods: Forty rats were divided into four groups: Group A (immunosuppressed, not-treated); GroupB (immunosuppressed, treated with S. boulardii); Group C (immunosuppressed, infected with S.sonnei, treated with S. boulardii); Group D (immunosuppressed, infected with S. sonnei). After takingsamples for blood cultures, the rats were sacrificed. The large bowel, liver, spleen and mesentericlymph nodes (MLN) were removed for microbiological examination.Results: S. boulardii in group B and S. sonnei in group D were isolated from blood in some rats.Statistical analysis of our data, showed that the numbers of translocated colonies in the liver andspleen were relatively higher for S. boulardii in Group B and for S. sonnei in Group D, withoutreaching levels of statistical significance. For MLN, colony counts in Group B was higher than GroupC and A showing statistical significance.Conclusion: The administration of S. boulardii showed promising results for the therapy of S. sonneiinfection in immunosuppressed rats, but therapeutic usage of S. boulardii should be carefully assessedby taking into consideration the risk it poses versus potential benefits in risk groups. en_US
dc.identifier.citationcount 0
dc.identifier.doi 10.30714/j-ebr.2020361049
dc.identifier.endpage 148 en_US
dc.identifier.issn 2618-6454
dc.identifier.issue 3 en_US
dc.identifier.startpage 141 en_US
dc.identifier.trdizinid 383978
dc.identifier.uri https://doi.org/10.30714/j-ebr.2020361049
dc.identifier.uri https://search.trdizin.gov.tr/tr/yayin/detay/383978/investigation-of-therapeutic-effect-of-saccharomyces-boulardii-and-translocation-in-immunosuppressed-rats-infected-with-shigella-sonnei
dc.identifier.uri https://hdl.handle.net/20.500.14517/1924
dc.identifier.volume 3 en_US
dc.institutionauthor Kaya, Ayşe Demet
dc.language.iso en
dc.relation.ispartof Experimental Biomedical Research en_US
dc.relation.publicationcategory Diğer en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.title Investigation of therapeutic effect of Saccharomyces boulardii and translocation in immunosuppressed rats infected with Shigella sonnei en_US
dc.type Article en_US

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