Analysis of Protein C Inhibitor/ SERPINA5
| dc.contributor.author | Nejat AKAR | |
| dc.contributor.author | Didem TORUN ÖZKAN | |
| dc.date.accessioned | 2024-05-25T12:20:17Z | |
| dc.date.available | 2024-05-25T12:20:17Z | |
| dc.date.issued | 2020 | |
| dc.department | Okan University | en_US |
| dc.department-temp | Türkiye Odalar ve Borsalar Birliği Eğitim ve Kültür Vakfı Hastanesi, Çocuk Sağlığı ve Hastalıkları Kliniği İstanbul Okan Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu | en_US |
| dc.description.abstract | Protein C inhibitor is a non-specific serine protease inhibitor with extensive protease reactivity. Protein C inhibitor (SERPINA5, plasminogen activator inhibitor-3/PAI-3) is a secreted, extracellular clade A serpin. SERPINA5/PCI has originally been described as an inhibitor of activated protein C and independently as an inhibitor of the plasminogen activator urokinase. SERPINA5 binds glycosaminoglycans, phospholipids, and retinoic acid. Glycosaminoglycans and certain phospholipids can modulate its inhibitory activity and specificity. PCI plays role at thrombosis and fibrinolysis, regulation of fertilization, tissue regeneration, vascular permeability, tumor development, invasion, metastasis and angiogenesis. In this review; aimed to provide information about the functions of PCI and to provide guidance for studies. | en_US |
| dc.identifier.citationcount | 0 | |
| dc.identifier.doi | 10.18663/tjcl.645392 | |
| dc.identifier.endpage | 79 | en_US |
| dc.identifier.issn | 2149-8296 | |
| dc.identifier.issue | 1 | en_US |
| dc.identifier.startpage | 75 | en_US |
| dc.identifier.trdizinid | 413824 | |
| dc.identifier.uri | https://doi.org/10.18663/tjcl.645392 | |
| dc.identifier.uri | https://search.trdizin.gov.tr/tr/yayin/detay/413824/analysis-of-protein-c-inhibitor-serpina5 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14517/1878 | |
| dc.identifier.volume | 11 | en_US |
| dc.language.iso | en | |
| dc.relation.ispartof | Turkish Journal of Clinics and Laboratory | en_US |
| dc.relation.publicationcategory | Diğer | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.title | Analysis of Protein C Inhibitor/ SERPINA5 | en_US |
| dc.type | Review | en_US |