TR Dizin İndeksli Yayınlar / TR Dizin Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14517/20

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Browsing TR Dizin İndeksli Yayınlar / TR Dizin Indexed Publications Collection by Author "Acil Tıp / Emergency Medicine"

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    Article
    Citation Count: 4
    Aberrant socs3 promoter methylation as a noninvasive diagnostic biomarker for locally advanced prostate cancer;
    (Logos Medical Publishing, 2020) Demircan Tan,B.; Yıldırım, Ali Osman; Yucel,B.; Altundag Kara,S.; Salman Yilmaz,S.; Yildirim,A.; Acil Tıp / Emergency Medicine
    Objective: The aim of this study was to investigate the promoter methylation status of Rasassociated domain family 1A (RASSF1A), O-6-methylguanine-DNA methyltransferase (MGMT), Phosphatase with tensin homology (PTEN) and Suppressor of cytokine signaling 3 (SOCS3) tumor suppressor genes and evaluate the clinical utility of these genes as noninvasive, bloodbased epigenetic biomarkers for the diagnosis of Prostate Cancer (PCa). Method: A total of 41 consecutive patients and 10 healthy control groups were enrolled in the study. Pyrosequencing was performed to analyze the methylation levels of the promoter regions of the four tumor suppressor genes in patients compared to healthy controls. Results: The promoter methylation levels of RASSF1A, MGMT, PTEN and SOCS3 did not differ between the patient and control groups. However, SOCS3 promoter methylation level was significantly higher for patients having locally advanced PCa compared to those having localized PCa (p<0.05). Conclusion: Our results indicated that SOCS3 could be a useful, noninvasive blood-based epigenetic biomarker for the diagnosis of locally advanced PCa. © Istanbul Medeniyet University Faculty of Medicine.
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    Article
    Citation Count: 0
    An unusual cause of hemorrhagic shock: gastric Dieulafoy’s lesion
    (2019) Yıldırım, Ali Osman; Osman Yıldırım; Murat Ferhat Ferhatoğlu; Hikmet Pehlevan; Kazım Şenol; Acil Tıp / Emergency Medicine
    Dieulafoy's lesion (DL) related massive gastrointestinal bleeding is a rare and mortal health condition. DL isa superficial vascular lesion of the gastric mucose that is mostly located in the proximal part of the stomachwhich is difficult to diagnose. Endoscopy is a safe and effective method for diagnosis and treatment. However,emergency surgery should be essential for diagnosis and treatment. Here we present a succesfull clinical andsurgical management of a case with massive gastrointestinal bleeding related to gastric DL.