TR Dizin İndeksli Yayınlar / TR Dizin Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14517/20

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Aberrant socs3 promoter methylation as a noninvasive diagnostic biomarker for locally advanced prostate cancer;
(Logos Medical Publishing, 2020) Demircan Tan,B.; Turan,T.; Yucel,B.; Altundag Kara,S.; Salman Yilmaz,S.; Yildirim,A.
Objective: The aim of this study was to investigate the promoter methylation status of Rasassociated domain family 1A (RASSF1A), O-6-methylguanine-DNA methyltransferase (MGMT), Phosphatase with tensin homology (PTEN) and Suppressor of cytokine signaling 3 (SOCS3) tumor suppressor genes and evaluate the clinical utility of these genes as noninvasive, bloodbased epigenetic biomarkers for the diagnosis of Prostate Cancer (PCa). Method: A total of 41 consecutive patients and 10 healthy control groups were enrolled in the study. Pyrosequencing was performed to analyze the methylation levels of the promoter regions of the four tumor suppressor genes in patients compared to healthy controls. Results: The promoter methylation levels of RASSF1A, MGMT, PTEN and SOCS3 did not differ between the patient and control groups. However, SOCS3 promoter methylation level was significantly higher for patients having locally advanced PCa compared to those having localized PCa (p<0.05). Conclusion: Our results indicated that SOCS3 could be a useful, noninvasive blood-based epigenetic biomarker for the diagnosis of locally advanced PCa. © Istanbul Medeniyet University Faculty of Medicine.
COVİD-19 Nedeni ile Hastaneye Yatırılan Hastalarda İnteratriyal Blok ve Repolarizasyonun Elektrokardiyografik Belirteçleri: Klasik ve Bayesyen Analiz
(Galenos Publ House, 2023) Guvenc, Rengin Cetın; Guren, Ali Kaan; Engur, Busra; Celık, Selin; Demırtunc, Refik
Amaç: Koronavirüs hastalığı-19 (COVİD-19) atriyal fibrilasyon (AF) ve ventriküler aritmiler ile ilişkilidir. Yüzey elektrokardiyografisindeki (EKG) çeşitli elektrofizyolojik anormallikler, anormal interatriyal iletimin veya anormal repolarizasyonun belirteçleri olarak AF ve ventriküler aritmilerle ilişkilendirilmiştir. Bu çalışmada, pandemi sırasında COVİD-19 enfeksiyonu ile hastaneye yatırılan hastalarda bu tür EKG belirteçlerinin daha yaygın olup olmadığı anlaşılmaya çalışılmıştır. Yöntemler: Toplam 87 COVİD-19 hastası çalışma grubunu oluştururken, COVİD-19 enfeksiyonu dışında herhangi bir nedenle hastaneye yatırılan 64 hasta kontrol grubu olarak çalışmaya dahil edildi. Kısmi ve ileri interatriyal blok (İAB) sıklığı, QT ve düzeltilmiş QT (QTc) süreleri, QT dispersiyonu (QTd) ve T tepeden uca süresi (Tpe) başvuru EKG’lerinden ölçüldü. Bulgular: COVİD-19 hastalarında hem kısmi hem de ileri İAB daha yaygındı, ancak istatistiksel anlamlılık yalnızca ileri İAB için gözlendi (COVİD-19 hastalarında %11,5’e karşı kontrollerde %0,0, p=0,005). QTc, QTd veya Tpe için gruplar arasında fark yoktu. Bayesyen analizlerde, COVİD-19 ile ileri İAB (BF10: 16) arasında bir ilişkiyi destekleyen güçlü kanıtlar bulunurken, kısmi İAB, QTc, QTd veya Tpe için bir ilişki olduğuna dair kanıt yoktu (hepsi için BF10<1). Sonuçlar: COVİD-19 ile hastaneye yatırılan hastalarda ileri İAB görülme olasılığı daha yüksektir ve bu durum AF’nin bu hastalarda neden daha sık görüldüğünü açıklayabilir.
Effects of Three Different Frequencies of Aerobic Physical Activity on Heart and Kidney Tissues in Type 2 Diabetes-Induced Rats
(2019) Gulcin BASDEMİR; Guldal GULEC SUYEN; NURAY ALACA; DİLEK ÖZBEYLİ; Hizir KURTEL; SERAP USLU
Objective: Exercise has many beneficial effects in the treatment and prevention of Type 2 Diabetes Mellitus (T2DM). The aim of this study was to evaluate the effect of physical activities with different frequencies performed within a total total duration of one week on the heart and kidney tissues and vascular endothelial growth factor (VEGF) expressions in experimental T2DM model. Method: Rats (n: 30) were divided into sedentary control (SC), sedentary T2DM (SD), T2DM and continuous exercise (DEc, 30 min/day, 5 days/week), T2DM and short bouts exercise (DEsb, 3x10 min/day, 5 days/week), T2DM and weekend warrior exercise (DEww, 35+40 min/day, 2 days/week) groups. Rats were administered streptozotocin (65 mg/kg) and nicotinamide (110 mg/kg) through intraperitoneal route. After 6-weeks of swimming exercise (total duration 150 min/week), biochemical analyzes were performed to measure oral glucose tolerance test, insulin sensitivity and cytokines. Histopathological and immunohistochemical analyses [VEGF, capillary density, Transforming growth factor beta (TGF-β)] were performed in heart and kidney tissues. Results: Compared with sedentary T2DM rats, significant improvements were observed in all exercise groups in terms of blood glucose level, insulin sensitivity, capillary density in heart tissue, VEGF expressions in tissues, TGF-β expressions in kidney tissue and all histopathological analysis (p<0.05). Conclusion: This study shows that physical activity at various frequencies may significantly ameliorate harmful effects of T2DM on heart and kidney tissue without significant differences between exercise frequencies, provided that the total duration of aerobic exercise remains the same (150 min/week).
Evaluation and Categorization of The Fishing Ports with a Fuzzy Spatial Multi Criteria Approach: The Case of Turkey
(Central Fisheries Research inst, 2017) Onden, Ismail; Samasti, Mesut; Canci, Metin; Eldemir, Fahrettin; Aktel, Abdullah
Fishing ports are the vital constituent of the fishery industry of Turkey. With governmental contribution, the number of the fishing ports reached to 366 alongside of the shores and the collected fish volume has been in increasing trend. However, there are differences in the location characteristics and technical infrastructure so that each facility's success level is measured differently with convenient parameters. To increase the performance of fishing ports, for their better utilization, and also to understand which of them can be transformed to regional centers a classification is needed. With the transformation to the regional centers, i.e. the infrastructure improvements of the facilities and providing multiple services such as tourism and transportation activities; the efficiency of the ports can be increased. In this paper, a classification methodology is developed and it is tested. While applying the methodology, expert workshops are carried out to represent current fishery environment in Turkey. In the meetings, decision criteria are discussed by participating over 200 experts in the field. f-AHP and GIS/Spatial Analysis is used to analyze spatial suitability. Results of the study showed that the methodology is capable of dealing with spatial and non-spatial characteristics of the data-set and determine the convenient alternatives.
Evaluation of Early Repolarization Pattern in Male Teenage Competitive Athletes and Association With Left Ventricular Remodeling
(Aves, 2021) Cetin, Suha; Akgun, Evic Zeynep; Babaoglu, Kadir
Objective: Early repolarization pattern (ERP) on electrocardiogram is more common among young athletes than in the general population, and has been considered a benign finding. However, ERP has been associated with increased risk of sudden cardiac death. The objectives of this study were to evaluate ERP in teenage athletes; investigate associations between ERP and echocardiographic findings of the left ventricle (LV); and to describe the impact of different sports disciplines on ERP. Methods: ERP was assessed in male teenage athletes from sports institutions for 5 different types of sport--basketball, swimming, football, wrestling, and tennis. All had been training for at least 3 hours per week for over at least 2 years. ERP was defined as J-point elevation >= 1 mV in 2 contiguous and/or lateral leads. A conventional echocardiography was performed in all athletes. Results: ERP was evaluated in 159 athletes with a mean age of 14 (range 10-18 years). It was more common in those training with combined exercise. There was no association between ERP and echocardiographic findings of left ventricular remodeling and geometric pattern. Conclusion: ERP is a frequent finding among teenage athletes. However, frequency varies by sports type, being more common in those training with combined exercise. It is not associated with structural echocardiographic alterations and is primarily seen as an electrophysiological change.
Investigation of Trace Element and Toxic Metal Blood Levels in Obese Children
(2025) Kılıç, Sinan
Dear Editor, Childhood obesity has become a major public health concern with increasing prevalence worldwide. Recent studies increasingly focus on the association between childhood obesity and environmental pollutants, exploring potential contributory pathways and mechanisms underlying this relationship. In a study published in the Turkish Archives of Pediatrics in 2024, we conducted an analysis of 50 obese children (26 girls, 24 boys) and a control group of 50 non-obese children (23 girls, 27 boys). Our findings indicated a significant reduction in levels of iron (Fe), magnesium (Mg), zinc (Zn), and cobalt (Co) among obese children, alongside a notable elevation in cop- per (Cu), lead (Pb), and manganese (Mn) levels.1 The study’s limitation is that while body weights were comparable across both groups, trace element blood levels did not follow a normal distribution, which should be considered in future research. Subsequent studies are encouraged to address weight discrepancies between obese and control groups and incorporate analyses that account for non-normally distributed data.
Investigation of Trace Element Levels and Toxic Metals in Obese Children: A Single-Center Experience
(AVES, 2024) Kılıç, Sinan; Kaba, Sultan
Objective: The complete role of factors contributing to the pathogenesis of childhood obesity remains to be fully elucidated. Limited research has addressed trace elements in the context of child obesity. Our objective was to assess trace element and lead (Pb), copper (Cu) (are toxic metal) levels in both healthy and obese children, and to investigate the potential correlations between these elements and obesity-related anthropometric measurements, lipid profiles, as well as insulin and glucose levels. Materials and Methods: Furnace atomic absorption spectrophotometry was employed to measure the concentrations of trace elements in the serum. Additionally, fasting glucose, insu- lin, and lipid levels were determined in obese children (body mass index ≥ 95th percentile for age and sex), along with 50 healthy children. Only the obesity group underwent an oral glucose tolerance test (OGTT). Results: Significantly reduced levels of Fe, Mg, Zn, and Co were observed in obese children, whereas Cu, Pb, and Mn levels were elevated (P < .001, P <.001, P = .002, P = .008, P <.001, P = .001, P = .007, respectively). Significant positive correlations were found between the 2-hour glucose level in OGTT and Mn (P = .013), as well as between peak insulin and insulin levels at the 30th and 60th minutes, and Fe (P = .001, P = .025, P = .001). Conclusion: This study indicates that an imbalance in trace element levels and the accumula- tion of Pb may be associated with obesity, while levels of Mn and Fe may be linked to glucose intolerance.
On finite nonsolvable groups whose cyclic p-subgroups of equal order are conjugate
(Tubitak Scientific & Technological Research Council Turkey, 2022) Van der Waall, Robert; Sezer, Sezgin
The structure of the nonsolvable (P)-groups is completely described in this article. By definition, a finite group G is called a (P)-group if any two cyclic p-subgroups of the same order are conjugate in G, whenever p is a prime number dividing the order of G.
Radiographic Acetabulotrochanteric Distance Measurement as a Novel Method for Determining Leg Length Discrepancy in Patients with Hemiarthroplasty
(Turkish Joint Diseases Foundation, 2025) Yesil, Murat; Yüzügüldü, Uğur; Maralcan, Gokhan; Yılmaz, Bilge Kağan; Bütüner, İbrahim Ethem
Objectives: This study aims to evaluate the interobserver reliability and interobserver reproducibility of radiographic acetabulotrochanteric distance (ATD) measurement and to investigate its accuracy by comparing it with conventional radiographic methods used in leg length discrepancy (LLD) measurement. Patients and methods: Between January 2017 and January 2022, a total of 97 patients (39 males, 58 females; mean age: 77.8±7.1 years; range, 61 to 91 years) who underwent pelvic radiographic evaluation and hemiarthroplasty (HA) due to femoral neck fracture were retrospectively analyzed. For ATD measurement, the distance between the line connecting the upper cartilage of the acetabulum (AC) and the extreme point of the greater trochanter (GT) was used. The AC-GT measurement on both sides was compared with bottom of the ischial tuberosities-lesser trochanter (BI-LT), center of the femoral head-BI (CH-BI), inferior acetabular teardrops-LT (IT-LT) measurements. The agreement between the methods was examined with the intraclass correlation coefficient (CCI). Results: According to the AC-GT & BI-LT, AC-GT & BI-CH methods, there were very strong (ICC: 0.75), moderate (ICC: 0.69) and acceptable (ICC: 0.33) agreements, respectively. Significant agreement was found between all measurements (p<0.001). A positive correlation was detected in the correlation analysis of all measurements (p<0.001). Intra- and interobserver agreement for ATD measurement (AC-GT) was excellent (ICC: >0.8). Conclusion: The ATD measurement correlates well with known measurement techniques on pelvic radiography and can be used as an alternative to this method. It has excellent intra- and interobserver agreements. This method can predict LLD after HA, but does not consider other length differences in the lower limbs.
Spatial Analysis of Effective Coastal Land Use Policies for the Development of Amateur Marine in Turkey
(2018) İsmail ÖNDEN; Metin ÇANCI
Recreational fishing, sailing, activities involving boating are parts of the social life-style which family members practicesoutdoors as social activities throughout the counties where maritime is common. It is being observed that, these kinds ofactivities tend to improve in Turkey within the recent years for the reasons like the increase in the national income andacculturation. Consequently, in order for satisfying this demand, new mooring areas with reasonable costs are required. Inorder to fulfill the berthing and mooring needs of the vessels, cost efficient and environmental solution approaches are need. This article aims to develop a system offering for constitution of sustainable policies with regards to determination of boats berthing and mooring areas that are needed for amateur marine in Turkey. For that reason, geographic information system (GIS) based approaches are taken into consideration for spatial analysis, which is used to specify suggested facilities regarding any component that generates the system. The results showed that the suggested method successfully functions regarding the selection of facility location, and it has been detected that by the suggested system approach, it is possible to achieve new and higher capacities.

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