Keleş, Gonca
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Name Variants
Keleş G.
KELEŞ Gonca
Keles, G.
Keleş, G.
Gonca KELES
Gonca, Keleş
Keles, Gonca
Çayır Keleş G.
Keleș G.
G., Keleş
Gonca Keleş
Keleş, Gonca
KELES Gonca
Keleş Gonca
Keles Gonca
Gonca Keles
Cayir Keles G.
Keles G.
Gonca KELEŞ
Keles, Gonca Cayir
KELEŞ Gonca
Keles, G.
Keleş, G.
Gonca KELES
Gonca, Keleş
Keles, Gonca
Çayır Keleş G.
Keleș G.
G., Keleş
Gonca Keleş
Keleş, Gonca
KELES Gonca
Keleş Gonca
Keles Gonca
Gonca Keles
Cayir Keles G.
Keles G.
Gonca KELEŞ
Keles, Gonca Cayir
Job Title
Prof.Dr.
Email Address
gonca.keles@okan.edu.tr
ORCID ID
Scopus Author ID
Turkish CoHE Profile ID
Google Scholar ID
WoS Researcher ID
Scholarly Output
7
Articles
6
Citation Count
0
Supervised Theses
0
7 results
Scholarly Output Search Results
Now showing 1 - 7 of 7
Article Citation Count: 1Histopathological and biochemical evaluation of paeoniflorin administration in an experimental periodontitis model(Nihon Univ, School dentistry, 2019) Gurkan, Cagla Gul; Keles, Gonca Cayir; Kurt, Sevda; Ciftci, Alper; Ayas, Bulent; Guler, Sevki; Cetinkaya, Burcu Ozkan; Periodontoloji / PeriodontologyThe purpose of this study was to evaluate the effects of administered Paeoniflorin (Pae) on periodontal tissues within an experimental periodontitis model. Forty male Wistar rats were used in this study and experimental periodontitis was created in all rats except in the control group (n = 10, first group). In the periodontitis group, experimental periodontitis was created but no other application was performed (n = 10, second group). In the other groups created experimental periodontitis, systemic Pae (n = 10, third group) or saline (n = 10, fourth group) was applied. A biochemical analysis of the gingival vascular endothelial growth factor (VEGF) levels and a histomorphometric analysis (measurements of the area of alveolar bone, alveolar bone resorption, and attachment loss) were performed. In the Pae group, the area of the alveolar bone was increased, while alveolar bone resorption and attachment loss decreased. Gingival VEGF levels increased in all groups that created experimental periodontitis and the greatest increase seen in the Pae group. Histomorphometric and biochemical analyses in this study suggest that Pae has a curative effect on periodontal tissues. However, additional studies are needed to confirm these results.Article Citation Count: 0Efficiency of oral keratinized gingiva detection and measurement based on convolutional neural network(Wiley, 2024) Aykol-Sahin, Gokce; Yucel, Ozgun; Eraydin, Nihal; Keles, Gonca Cayir; Unlu, Umran; Baser, Ulku; Periodontoloji / PeriodontologyBackground: With recent advances in artificial intelligence, the use of this technology has begun to facilitate comprehensive tissue evaluation and planning of interventions. This study aimed to assess different convolutional neural networks (CNN) in deep learning algorithms to detect keratinized gingiva based on intraoral photos and evaluate the ability of networks to measure keratinized gingiva width. Methods: Six hundred of 1200 photographs taken before and after applying a disclosing agent were used to compare the neural networks in segmenting the keratinized gingiva. Segmentation performances of networks were evaluated using accuracy, intersection over union, and F1 score. Keratinized gingiva width from a reference point was measured from ground truth images and compared with the measurements of clinicians and the DeepLab image that was generated from the ResNet50 model. The effect of measurement operators, phenotype, and jaw on differences in measurements was evaluated by three-factor mixed-design analysis of variance (ANOVA). Results: Among the compared networks, ResNet50 distinguished keratinized gingiva at the highest accuracy rate of 91.4%. The measurements between deep learning and clinicians were in excellent agreement according to jaw and phenotype. When analyzing the influence of the measurement operators, phenotype, and jaw on the measurements performed according to the ground truth, there were statistically significant differences in measurement operators and jaw (p < 0.05). Conclusions: Automated keratinized gingiva segmentation with the ResNet50 model might be a feasible method for assisting professionals. The measurement results promise a potentially high performance of the model as it requires less time and experience.Article Citation Count: 0TEACHERS' OPINIONS ON TECHNOLOGY LEADERSHIP ROLES OF SCHOOL PRINCIPALS DURING THE COVID-19 PANDEMIC(Anadolu Univ, 2024) Simsek, Yucel; Sert, Tamer; Himmetoglu Dal, Beyza; Periodontoloji / Periodontology; Ağız,Diş ve Çene Radyolojisi / Oral, Dental and Maxillofacial RadiologyThe main purpose of this study is to examine the opinions of teachers about technology leadership roles of school principals during the Covid-19 pandemic. The study, which utilized qualitative research methods, was designed as a survey study. Sample group of the study constituted of 259 teachers. Data of the study was collected with "Elementary School Principals' Technology Leadership Role Scale" and analyzed via descriptive statistics, independent sample t-test, one-way ANOVA and Mann Whitney-U test. According to the results, both elementary school teachers and subject matter teachers think that school principals successfully demonstrated the role of technology leadership roles during the Covid-19 pandemic. As a result of the analyses conducted to determine whether teachers' opinions vary according to various variables, it was concluded that there are no differences in terms of the entire scale and its dimensions based on genders and seniority of teachers. In terms of the working domain, it was seen the opinions of elementary school teachers on vision dimension are higher than those of subject matter teachers. Based on the results, some recommendations which can contribute to both implementation and theory have been developed. Accordingly, conducing researches which employ multiple data collection methods and tools to investigate technology leadership roles of school principals is considered important.Article Citation Count: 0Comparison of the effectiveness of Ankaferd Blood Stopper(R) and Emdogain in periodontal regeneration(Wiley, 2022) Guler, Sevki; Cetinkaya, Burcu Ozkan; Kurt Bayrakdar, Sevda; Ayas, Bulent; Keles, Gonca Cayir; Periodontoloji / PeriodontologyObjectives The present study was performed to compare the effectiveness of Ankaferd Blood Stopper(R) (ABS) with enamel matrix derivatives (EMD) for treating fenestration defects in rats. Materials and Methods Forty-eight male Wistar rats were randomly divided into six groups (each n = 8). Fenestration defects were created in all rats, to which ABS, EMD, or saline (S) was then applied. The rats were grouped and sacrificed at one of two different time points, as follows: ABS-10-group, ABS-treatment/sacrifice on day 10; EMD-10-group, EMD-treatment/sacrifice on day 10; S-10-group, S-treatment/sacrifice on day 10; ABS-38-group, ABS-treatment/sacrifice on day 38; EMD-38-group, EMD-treatment/sacrifice on day 38; and S-38-group, S-treatment/sacrifice on day 38. Then, histomorphometric analysis including measurements of new bone area (NBA) and new bone ratio (NBR), and immunohistochemical analysis including the determination of osteopontin (OPN) and type-III-collagen (C-III) expression were performed. Results The NBA and NBR were significantly higher in the ABS-10-group and EMD-10-group compared to the S-10-group (p < .05), and in the EMD-38-group compared to the S-38-group (p < .05). The levels of C-III and OPN immunoreactivity were significantly higher in the ABS-10-group compared to the S-10-group (p < .017). Conclusions The results of this study suggested that ABS can promote early periodontal regeneration, although its efficacy seems to decrease over time.Article Citation Count: 0Dental Biyofilme Bağlı Gingivitis Tedavisinin Hastaların Tat Algıları Üzerine Etkisi(2023) Şahin, Gökçe Aykol; Kayahan, Mehmet Baybora; Keleş, Gonca; Koran, Serpil Melek Altan; Periodontoloji / PeriodontologyGiriş ve Amaç: Tat algısı, genetik, yapısal ve çevresel pek çok faktöre bağlıdır. Kronik inflamasyonun, tat bozukluklarında et- ken faktörlerden biri olduğu düşünülmektedir. Bu çalışmada, dental biyofilme bağlı, inflamatuar karakterde bir dişeti hasta- lığı olan gingivitisli hastaların, tedavi sonrası tat algılarındaki değişiminin değerlendirilmesi amaçlandı. Gereç ve Yöntem: Çalışmada hastaların başlangıç periodon- tal durumu Quigley-Hein plak indeksi (Turesky modifikasyo- nu), gingival indeks, sondalamada kanama ve sondalanabilir cep derinliğini içeren periodontal indeks ve ölçümlerle; tat algıları, 6-n propiltiourasil (PROP) (0.32 mmol/l) ve NaCl (0.1 mol/l) solüsyonları ile ağız çalkalatılıp Etiketli Büyüklük Skala- sı kullanılarak değerlendirildi. Çalışmaya dahil edilen orta ve şiddetli gingivitisi olan hastalara Faz I tedavi uygulandı. Pe- riodontal değerlendirmeler ve tat algısı değerlendirmeleri 1. haftada ve 1. ayda tekrarlandı. Veriler IBM SPSS 21.0 programı ile istatistiksel olarak değerlendirildi. Bulgular: Çalışma grubu; 16’sı kadın (27.88 ± 0.93 yaş ort.) ve 15’i erkek (28.6 ± 1.3 yaş ort.) 31 hastadan oluştu. Demografik verilerde istatistiksel olarak bir farklılık bulunmadı. Hastaların başlangıca göre 1. hafta ve 1. ayda değerlendiren tüm klinik parametrelerinde istatistiksel anlamlı düzeyde iyileşme göz- lendi (p <0.05). PROP ve NaCl solüsyonları ile değerlendirilen tat algılarında, yine başlangıca göre tedavi sonrası 1. hafta ve 1. ay değerlendirmelerinde anlamlı düzeyde artış gözlendi (p <0.001). Sonuç: Çalışmada periodontal tedavi sonrası orta ve şiddetli gingivitis hastalarında klinik parametrelerdeki iyileşme ile ko- rele olarak tat algılarında anlamlı düzeyde artış gözlendi. Kısıtlı bir popülasyonda yapılan bu çalışmanın hastalardan geri bil- dirimin alındığı, proinflamatuar sitokin değişimlerinin de de- ğerlendirildiği daha kapsamlı çalışmalarla desteklenmesine ihtiyaç vardır.Conference Object Citation Count: 7Nonsurgical Periodontal Therapy Reduces Salivary and Gingival Crevicular Fluid YKL-40 and IL-6 Levels in Chronic Periodontitis(Quintessence Publishing Co inc, 2020) Yucel, Zeynep Pinar Keles; Keles, Gonca Cayir; Avci, Bahattin; Cetinkaya, Burcu Ozkan; Periodontoloji / PeriodontologyPurpose: A novel acute-phase protein, YKL-40, is known as an inflammation-associated glycoprotein. YKL-40 is shown to be linked to inflammation, endothelial dysfunction and tissue remodeling secreted by various cells and is also considered to be stimulated by cytokines such as interleukin-6 (IL-6). The present study aimed to investigate YKL-40 and IL-6 levels in saliva and gingival crevicular fluid (GCF) of patients with chronic periodontitis (CP) after non-surgical periodontal therapy for the first time. Materials and Methods: Twenty-six CP patients and 26 periodontally healthy individuals were enrolled. Clinical measurements were recorded; saliva and GCF samples were obtained at baseline and 1 and 3 months after nonsurgical periodontal therapy. Levels of YKL-40 and IL-6 in saliva and GCF were analysed by ELISA. Results: Salivary and GCF YKL-40 and IL-6 levels were found to be statistically significantly higher in CP patients compared to healthy controls at baseline (p < 0.001). At 1 and 3 months after the completion of treatment, both YKL-40 and IL-6 levels in saliva and GCF had statistically significantly decreased compared with baseline values in CP patients (p < 0.001). On the other hand, no statistically significant difference was observed between 1 and 3 months in terms of salivary and GCF YKL-40 and IL-6 levels or any of the clinical findings (p > 0.016). Conclusion: Salivary and GCF YKL-40 levels may be useful to evaluate resolution of periodontal inflammation. Within the limits of this study, YKL-40 acute-phase protein might be a potential biomarker for detection of periodontitis and monitoring the response to periodontal therapy.Article Citation Count: 4Clinical and biochemical evaluation of oral irrigation in patients with peri-implant mucositis: a randomized clinical trial(Springer Heidelberg, 2022) Tutuncuoglu, Sema; Cetinkaya, Burcu Ozkan; Pamuk, Ferda; Avci, Bahattin; Keles, Gonca Cayir; Kurt-Bayrakdar, Sevda; Lutfioglu, Muge; Periodontoloji / PeriodontologyObjective This randomized clinical trial aimed to compare the efficacy of an oral irrigator and an interdental brush in patients with peri-implant mucositis clinically and biochemically at different time points (at baseline and at the 2nd, 4th, and 12th weeks). Materials and methods Forty-five patients with at least one implant with peri-implant mucositis were included in the present study (n = 45). The patients were divided into three groups: oral irrigator + toothbrush (OI group, n = 15), interdental brush + toothbrush (IB group, n = 15), and toothbrush only (control) (C group, n = 15). The modified plaque index (mPlI), modified sulcus bleeding index (mSBI), probing pocket depth (PPD), probing attachment level (PAL), and bleeding on probing (BOP) were recorded at baseline and at the 2nd, 4th, and 12th weeks. The levels of interleukin 1 beta (IL-1 beta), transforming growth factor-beta (TGF-beta), tissue-type plasminogen activator (t-PA), and plasminogen activator inhibitor-1 (PAI-1) were also determined in the peri-implant crevicular fluid samples biochemically. Results The mSBI and t-PA at the 2nd week (p = 0.003; p = 0.003); the mPlI, mSBI, BOP, t-PA, and PAI-1 at the 4th week (p < 0.05; p < 0.001; p < 0.001; p = 0.015; p = 0.011); and the mPlI, mSBI, IL-1 beta, t-PA, and PAI-1 at the 12th week (p < 0.05; p < 0.001; p = 0.013; p < 0.001; p = 0.002) were significantly lower in the OI group compared with those in the C group. Meanwhile, PAI-1 at the 2nd week, mSBI at the 4th week, and t-PA at the 12th week were significantly lower in the OI group compared with those in the IB group (p < 0.001; p = 0.011; p = 0.003). At the 2nd, 4th, and 12th weeks, all other parameters were not statistically different in the three groups. Conclusion The clinical indexes (such as mSBI and BOP) that play an important role in the diagnosis of peri-implant mucositis showed the lowest means (although limited) in the OI group at all evaluation time points. Moreover, when the clinical and biochemistry results were interpreted altogether, it became apparent that the OI group exhibited similar or more effective results than the IB group in resolving peri-implant mucositis. In light of the foregoing, this study concluded that the use of an oral irrigator can be as effective as an interdental brush in interdental cleaning.
