Altunkaynak, Berrin Zühal
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Berrin Z. Altunkaynak
Berrin Zühal, Altunkaynak
Altunkaynak, Berrin
ALTUNKAYNAK Berrin Zühal
Altunkaynak, Berrin Zühal
Berrin Zühal ALTUNKAYNAK
Altunkaynak, Zuhal
Altunkaynak Berrin Zuhal
Altunkaynak, B.
Altunkaynak Berrin Zühal
B. Zühal Altunkaynak
B. Z. ALTUNKAYNAK
ALTUNKAYNAK Berrin Zuhal
Berrin Zühal Altunkaynak
Zuhal Altunkaynak B.
Berrin Zuhal Altunkaynak
B. Zuhal Altunkaynak
Altunkaynak B.
Altunkaynak, Zühal
B. Z. Altunkaynak
Berrin Zuhal ALTUNKAYNAK
Altunkaynak, Z.
Altunkaynak, B. Z.
Altunkaynak, Berrin Zuhal
Altunkaynak,B.Z.
Berrin Zühal, Altunkaynak
Altunkaynak, Berrin
ALTUNKAYNAK Berrin Zühal
Altunkaynak, Berrin Zühal
Berrin Zühal ALTUNKAYNAK
Altunkaynak, Zuhal
Altunkaynak Berrin Zuhal
Altunkaynak, B.
Altunkaynak Berrin Zühal
B. Zühal Altunkaynak
B. Z. ALTUNKAYNAK
ALTUNKAYNAK Berrin Zuhal
Berrin Zühal Altunkaynak
Zuhal Altunkaynak B.
Berrin Zuhal Altunkaynak
B. Zuhal Altunkaynak
Altunkaynak B.
Altunkaynak, Zühal
B. Z. Altunkaynak
Berrin Zuhal ALTUNKAYNAK
Altunkaynak, Z.
Altunkaynak, B. Z.
Altunkaynak, Berrin Zuhal
Altunkaynak,B.Z.
Job Title
Prof.Dr.
Email Address
zuhal.altunkaynak@okan.edu.tr
Main Affiliation
Histoloji ve Embriyoloji / Histology and Embriology
Status
Website
ORCID ID
Scopus Author ID
Turkish CoHE Profile ID
Google Scholar ID
WoS Researcher ID
Scholarly Output
31
Articles
28
Citation Count
0
Supervised Theses
0
31 results
Scholarly Output Search Results
Now showing 1 - 10 of 31
Article Citation - WoS: 5Citation - Scopus: 4Effect of Luteolin on Biochemical, Immunohistochemical, and Morphometrical Changes in Rat Spinal Cord following Exposure to a 900 MHz Electromagnetic Field(Chinese Center Disease Control & Prevention, 2020) Yahyazadeh, Ahmad; Altunkaynak, Berrin Zuhal; Histoloji ve Embriyoloji / Histology and EmbriologyObjective This study aimed to investigate the effect of exposure to a 900 MHz electromagnetic field (EMF) on the cervical spinal cord (CSC) of rats and the possible protective effect of luteolin (LUT) against CSC tissue damage. Methods Quantitative data were obtained via stereological, biochemical, immunohistochemical, and histopathological techniques. We investigated morphometric value, superoxide dismutase (SOD) level, and the expression of high-mobility group box 1 protein molecules, as well as histological changes. Results The total number of motor neurons in the EMF group significantly decreased in comparison with that in the control group (P < 0.05). In the EMF + LUT group, we found a significant increase in the total number of motor neurons compared with that in the EMF group (P < 0.05). SOD enzyme activity in the EMF group significantly increased in comparison with that in the control group (P < 0.05). By contrast, the EMF+LUT group exhibited a decrease in SOD level compared with the EMF group (P < 0.05). Conclusion Our results suggested that exposure to EMF could be deleterious to CSC tissues. Furthermore, the protective efficacy of LUT against SC damage might have resulted from the alleviation of oxidative stress caused by EMF.Article Citation - Scopus: 0Momordica charantia Enhances Tendon Healing in Rats: An Experimental Study(S. Karger AG, 2024) Erdoğan,F.; Kaplan,A.A.; Coşkun,H.S.; Altun,G.; Altunkaynak,B.Z.; Kelsaka,E.; Pişkin,A.; Histoloji ve Embriyoloji / Histology and EmbriologyMomordica charantia (MC) is a traditional plant widely used since ancient times for wound healing. This study evaluated its potential effects on tendon healing. Adult male Wistar albino rats (n = 32, 8 rats in each group) were anesthetized, and their Achilles tendons were prepared for surgical procedures. Group 1 (Cont = control group) was not subjected to any surgery and was used as a control group for baseline values. Group 2 (PR = primary repair group) underwent primary repair (PR) with a monofilament suture after a full-thickness incision of the Achilles tendon. A full-thickness incision was also made to the Achilles tendon of group 3 (CT = collagen tube-administered group), followed by PR and collagen tube insertion. In group 4 (MC = M. charantia-administered group), 1 mL of MC extract was applied locally on the collagen tube in addition to the surgical procedure applied to group 3. The Achilles tendons were excised on the postoperative 40th day and examined stereologically, histologically, and bioinformatically. Data showed that the total volume of the collagen fibers was higher in MC and CT groups than in the PR group. The total volume of the tendon was decreased in MC and CT groups than in the Cont group. The ratios between the volumes of the collagen fibers and total tendon in the MC and CT groups were significantly different from PR, but not different from the Cont group. Additionally, MC improved tenoblastic activity, collagen production, and neovascularization. Bioinformatic interactions showed that the proteases of MC could trigger the signals playing a role on vasculogenesis, reducing inflammation, and contributing to tenoblast activation and collagen remodeling. MC extract ameliorates the healing of injured tendon and can provide satisfactory tendon repair. Further works are recommended to explore the healing capacity of MC. © 2023 S. Karger AG, Basel.Review Citation - WoS: 13Melatonin and sciatic nerve injury repair: a current perspective(Dove Medical Press Ltd, 2018) Altunkaynak, Berrin Zuhal; Delibas, Burcu; Altun, Gamze; Deniz, Omur Gulsum; Histoloji ve Embriyoloji / Histology and EmbriologyPeripheral nerve injury is an important clinical problem that can exert hazardous effects on the health of patients. For this reason, there are more studies conducted on the regeneration of the peripheral nerves via the usage of the nerves belonging to various animals with different types of lesions, ages, and by using different methods of assessment with regular follow-up. Contrary to data obtained through experimentation and clinical observation, no ideal way of treatment was found to increase the regeneration of the peripheral nerves. Finally, the effects of melatonin in the protection of peripheral nerves against trauma, especially the protection of sciatic nerve from pathological conditions, have come into attention in a wide group of scientists as there are beneficial effects of melatonin after surgery. While numerous studies indicate the melatonin's protective effects on the pathologies of nerves, there are also studies reporting its toxic effects on peripheral nerves. Melatonin is a widespread and crucial signaling molecule due to its features of free radical scavenging and anti-oxidation at both pharmacological and physiological conditions in vivo. In this context, although there are numerous studies elaborating the effects of melatonin in various tissues, its effects on peripheral nerves was documented in only a limited number of studies. The aim of this article was to perform a review of the knowledge in the literature on the subject of mostly beneficial or hazardous effects of melatonin on the repair of the damaged peripheral nerves.Article Citation - WoS: 9Citation - Scopus: 11Histomorphometric changes in the placenta and umbilical cord during complications of pregnancy(Taylor & Francis inc, 2018) Gueven, D.; Altunkaynak, B. Z.; Altun, G.; Alkan, I.; Kocak, I.; Histoloji ve Embriyoloji / Histology and EmbriologyPregnancy complications may cause morphological changes and circulation defects in the placenta, which may lead to morbidity and mortality in fetuses and newborns. We investigated structural changes in the placenta and umbilical cord under various abnormal maternal conditions. Placenta and umbilical cord specimens were obtained from pregnant women during labor at 37 - 42 weeks gestation. Volumetric measurements were made for each placenta and umbilical cord using the Cavalieri method. Significant differences were observed for volumetric densities of total villi, syncytial knots, intervillous vessels and perivillous fibrin deposition. We observed particular increases in the volumetric parameters of the pre-eclampsia group compared to the other groups. The tunica media of the umbilical arteries was increased significantly with intrahepatic cholestasis.Article Citation - WoS: 9Citation - Scopus: 11A stereological study of the effects of mercury inhalation on the cerebellum(Taylor & Francis Ltd, 2019) Altunkaynak, Berrin Zuhal; Akgul, Nilgun; Yahyazedeh, Ahmad; Makaraci, Emine; Akgul, Hayati Murat; Histoloji ve Embriyoloji / Histology and EmbriologyMercury in the environment that arises from organic and inorganic sources can cause irreversible damage to the nervous system. Toxicity may be direct or may arise from interactions with other metals in the environment. We evaluated the possible effects of mercury vapor on rat cerebellum. Twelve adult female rats were divided into control and experimental groups. The rats in the experimental group were exposed to mercury vapor for 9 h/day for 45 days. Cerebellar tissue samples were evaluated using stereology and for histopathology. The total number of Purkinje cells was estimated using a physical disector method. We found that in the experimental group, overall volume decreased and the number of Purkinje cells was reduced. We also found cellular damage including pycnotic nuclei, eosinophilic cytoplasm and vacuolization; these features were absent in the control group. We found that chronic exposure to inorganic mercury vapor is toxic to the cerebellum.Review Periferik Sinir Yaralanmaları ve Rejenerasyonu(2022) Berrin Zuhal ALTUNKAYNAK; Işınsu Aydın Alkan; Esra BEKAR; Histoloji ve Embriyoloji / Histology and EmbriologyPeriferik sinirler merkezi sinir sistemi ve periferal organlar arasındaki motor ve duyu uyarımını sağlayan hedef organda uyardıkları fonksiyonlara göre isimledirilen çeşitli sinir liflerinden oluşan sistemdir. Travmalara oldukça açık bulunan periferik sinirlerde farklı sebepler ile yaralanmalar gözlemlenir. Bu şekilde periferik sinirlerde oluşabilecek hasar kişinin motor ve duyu uyarımını olumsuz etkilemektedir. Periferal yaralanmaların ardından perifrerik sinirde hasara bağlı olarak dejeneratif süreçler başlatılır. Aksonal devamlılığı kesintiye uğratacak derecedeki yaralanmalarda aksonda sinir fonksiyonunun devamlılığı için gereken metabolik olaylar gerçekleşemediği için distal kısımlar dejenerasyona uğrar. Periferik sinir rejenerasyonunda Schwann hücre dediferansiyasyonu, proliferasyonu ve remiyelinizasyon önemli rol oynar. Rejeneratif süreç ise oldukça fazla faktörün bir arada çalıştığı bir süreçtir. Bu derlemede, periferik sinirde meydana gelen yaralanmaların ardından gerçekleşen rejenerasyon süreci, ayrıca rejenerasyona etki eden nörotrofik faktörler ve tedavi sürecinde kullanılan farklı metotların etki mekanizmalarına değinilmiştir.Article Citation - WoS: 5Citation - Scopus: 4The morphometrical and immunohistochemical investigation of the effect of topiramate on liver and the role of neuropeptide Y receptor in an obese female rat(Comenius Univ, 2020) Yahyazadeh, A.; Altunkaynak, B. Z.; Alkan, I; Histoloji ve Embriyoloji / Histology and EmbriologyOBJECTIVE: We aimed to investigate the possible effect of topiramate (TOP, 0.02 mg/kg/day) on the livers in a high-fat diet (HFD)-induced obesity rat model. The other objective was to evaluate the relationship between TOP administration and NPY level using anti-NPY1R antibody. METHODS: Twenty-four adult female Wistar albino rats were randomly assigned into four equal groups as follow: control (CONT), obese (OBS), TOP, and OBS+TOP. All liver samples were investigated using the stereological analysis, as well as immunohistochemical and histopathological examination. RESULTS: The total number of hepatocytes was significantly decreased in the OBS+TOP group compared to the CONT group or the OBS group (p < 0.05). We found a significant increase in the mean volume of liver in the OBS group compared to the CONT group (p < 0.05). Also, the mean volume of liver was significantly decreased in the OBS+TOP group compared to the OBS group (p < 0.05). CONCLUSION: Taken together, our findings suggest that decreased liver volume is possibly attributed to TOP administration via setting the NPY level in the obese rats. Further, the side effects of TOP in combination with health risk of obesity may have led to an increase in hepatotoxicity and the subsequent hepatocyte loss (Fig. 7, Ref. 56). Text in PDF www.elis.skReview Citation - WoS: 1Citation - Scopus: 1Applications of various stereological tools for estimation of biological tissues(Wiley, 2023) Warille, Aymen A.; Kocaman, Adem; Elamin, Abdalla A.; Mohamed, Hamza; El Elhaj, Abubaker; Altunkaynak, Berrin Zuhal; Histoloji ve Embriyoloji / Histology and EmbriologyTo provide concise and brief important stereological application methods and techniques for estimating biological tissues. Stereology studies the quantity of biological tissue using little practice and the low price of counting and preparing tissue slices to obtain direct and accurate results. Since their establishment, the stereological techniques underwent much improvement, thus allowing more precise analysis of target structures using various approaches. Using stereological tools, advances in stereological techniques made the target tissues or organs represented by 2D instead of 3D dimensions. Process tools estimate volume, area and length. According to the exciting tissue and aims, the stereological tools perform differently. This review summarizes various stereological tools and techniques, providing brief information about the orientation method, slicer probe method, Delesse's principle, Cavalieri principle, disector, fractionator, nucleator, virtual cycloids and saucer, which are described in detail.Article Citation - WoS: 15Citation - Scopus: 18Biochemical, immunohistochemical and morphometrical investigation of the effect of thymoquinone on the rat testis following exposure to a 900-MHz electromagnetic field(Elsevier Gmbh, 2020) Yahyazadeh, Ahmad; Altunkaynak, Berrin Zuhal; Kaplan, Suleyman; Histoloji ve Embriyoloji / Histology and EmbriologyLong-term use of cell phones emitting electromagnetic fields (EMFs) have raised concerns regarding public health in recent year. We aimed to investigate the possible effects of 900 MHz EMF exposure (60 min/day for 28 days) on the rat testis. Another objective was to determine whether the deleterious effect of EMF radiation would be reduced by the administration of thymoquinone (TQ) (10 mg/kg/day). Twenty-four male adult Wistar albino rats were randomly selected, then assigned into four groups as followControl, EMF, TQ and EMF + TQ. Testicular samples were analyzed using histological, stereological, biochemical and immunohistochemical techniques. Total numbers of primary spermatocytes and spermatids as well as Leydig cells were significantly decreased in the EMF group compared to the Control group (p < 0.05). In the EMF + TQ group, the total number of primary spermatocytes was significantly increased compared to the EMF group (p < 0.05). Superoxide dismutase (SOD) activity was significantly increased in the EMF group compared to the Control group (p< 0.05). Also, serum testosterone levels and wet weight of testes were significantly decreased in the EMF group compared to the Control group (p < 0.05). Our findings suggested that exposure to a 900 MHz EMF had adverse effects on rat testicular tissue and that the administration of TQ partially mitigated testicular oxidative damages caused by EMF radiation.Article Citation - WoS: 0Citation - Scopus: 0Imiquimod Inhibits Proliferation of Serous Epithelial Ovarian Cancer Cells In Vitro: A Preliminary Study(Springer india, 2020) Kokcu, Arif; Alper, Tayfun; Ogur, Gonul; Akar, Omer Salih; Ozdes, Emel Kurtoglu; Altunkaynak, Berrin Zuhal; Histoloji ve Embriyoloji / Histology and EmbriologyPurpose Imiquimod, known as positive immune response modifier and stimulates local cytokine induction, has been used in therapy of genital warts via increasing local interferon and reducing human papillomavirus production. We aimed to investigate whether imiquimod has any effect on the proliferation of serous epithelial ovarian cancer cells in vitro. Methods The study was designed in two stages. The first stage was designed to evaluate co-culturing of serous epithelial ovarian cancer cells with the drug imiquimod versus cancer cells cultured with no drug. The second stage of the study was initiated with primary ovarian cancer cell culture growth. Imiquimod was applied in increasing concentrations to flasks full of each kind of cells. Also, histomorphometrical evaluation was made using an unbiased counting frame. Results Treatment of the primary cancer cell cultures with imiquimod in concentrations of 2.5 mu g/ml and 5.0 mu g/ml did not result in a significant effect on cell proliferation and the cell proliferation continued. Cell proliferation stopped and the cells detached at concentrations of 7.5 mu g/ml, especially 10.0 mu g/ml, 12.5 mu g/ml, and 25.0 mu g/ml, within 2-3 days after exposure to the drug. The anti-proliferative effect of imiquimod reached a maximum level at a concentration of 12.5 mu g/ml. Conclusions Imiquimod has a dose-dependent anti-proliferative impact on serous epithelial ovarian cancer cells in vitro.
