Altunkaynak, Berrin Zühal

Name Variants

Berrin Z. Altunkaynak
Berrin Zühal, Altunkaynak
Altunkaynak, Berrin
ALTUNKAYNAK Berrin Zühal
Altunkaynak, Berrin Zühal
Berrin Zühal ALTUNKAYNAK
Altunkaynak, Zuhal
Altunkaynak Berrin Zuhal
Altunkaynak, B.
Altunkaynak Berrin Zühal
B. Zühal Altunkaynak
B. Z. ALTUNKAYNAK
ALTUNKAYNAK Berrin Zuhal
Berrin Zühal Altunkaynak
Zuhal Altunkaynak B.
Berrin Zuhal Altunkaynak
B. Zuhal Altunkaynak
Altunkaynak B.
Altunkaynak, Zühal
B. Z. Altunkaynak
Berrin Zuhal ALTUNKAYNAK
Altunkaynak, Z.
Altunkaynak, B. Z.
Altunkaynak, Berrin Zuhal

Job Title

Prof.Dr.

Email Address

zuhal.altunkaynak@okan.edu.tr

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Scholarly Output

26

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23

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0

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Now showing 1 - 10 of 26

Citation Count: 7
Is melatonin, leptin or their combination more effective on oxidative stress and folliculogenesis in the obese rats?
(Taylor & Francis inc, 2020) Kirikci, Gamze; Altunkaynak, Berrin Zuhal; Kaplan, Suleyman; Histoloji ve Embriyoloji / Histology and Embriology
In this study, we evaluated the effects of melatonin (Mel), leptin (Lep) or melatonin and leptin treatment on ovaries in control and obese rats. The animals were divided into control (NC), melatonin (NM), leptin (NL), melatonin?leptin (NML), obese (OC), obese?melatonin (OM), obese?leptin (OL), obese?melatonin?leptin (OML) groups. Body weights, peri-ovarian fat pads, volumetric parameters and numerical values of follicles were estimated. Also, the LH receptor (LHr) immune-positivity, catalase (CAT) and the myeloperoxidase (MPO) levels were determined. The body weight and peri-ovarian fat pads were significantly decreased following Mel (p?
Citation Count: 2
Protective effect of indole-3-carbinol on testis of a high fat diet induced obesity
(Taylor & Francis Ltd, 2023) Tufek, Nur Hande; Yahyazadeh, Ahmad; Altunkaynak, Berrin Zuhal; Histoloji ve Embriyoloji / Histology and Embriology
We investigated the effects of obesity caused by a high fat diet (HFD) on rat testes and evaluated the possible protective effects of indole-3-carbinol (IND). We used 24 8-10-week-old 200 g male rats randomly assigned to 4 groups: non-obese control (NC), obese control (OC), non-obese IND group (NI), obese + IND group (OI). Testis samples were examined using stereological, immunohistochemical, biochemical and histological methods. The number of spermatogenic cells, Leydig cells, mean volume of testes and seminiferous tubules was significantly decreased in the OC group compared to the NC group, but these values were increased significantly in the OI group compared to the OC group. We found a significant increase in catalase and myeloperoxidase activities in the OC group compared to the NC group. In the OI group, catalase and myeloperoxidase levels were decreased compared to the OC group. TUNEL-positive cells also were increased in the OC group compared to the NC group (p < 0.05), but these were fewer in the OI group than the OC group. We found marked morphological changes in testicular tissues between the NC and OC groups, as well as between the OI and OC groups. We found that HFD induced obesity was detrimental to rat testes and that administration of IND ameliorated testicular changes caused by obesity.
Citation Count: 13
Investigation of the neuroprotective effects of thymoquinone on rat spinal cord exposed to 900 MHz electromagnetic field
(Elsevier, 2019) Yahyazadeh, Ahmad; Altunkaynak, Berrin Zuhal; Histoloji ve Embriyoloji / Histology and Embriology
Exposure to electromagnetic field in long-term use of cell phones has increased concerns about serious health problems. Our aim was to survey the possible effects of electromagnetic field radiation (60 min/day for 28 days) on the spinal cords of 12 weeks old rats. Further, we investigated whether the administration of thymoquinone (10 mg/kg/day) would protect the spinal cord tissue against the adverse effects of electromagnetic field or not. Twenty-four adult male Wistar albino rats were assigned randomly into four groups: control, electromagnetic field, thymoquinone and electromagnetic field + thymoquinone. The cervical spinal cords of all rats was evaluated using the stereological, biochemical and histological methods. The number of motor neurons were reduced in the electromagnetic field group compared to the control group (p < 0.05). Superoxide dismutase level was higher in the electromagnetic field group compared to the control group (p < 0.05). In the electromagnetic field + thymoquinone group, we found an increase in the number of motor neurons and decrease in superoxide dismutase activity compared to the electromagnetic field group (p < 0.05). Our histological findings also exhibit the remarkable architectural alterations. We speculated that electromagnetic field radiation induced the morphological and biochemical damage to the spinal cord tissue of rats. Administration of antioxidant, thymoquinone, also ameliorated such complications caused by electromagnetic field.
Citation Count: 10
Histological Study of The Healing of Traumatic Tympanic Membrane Perforation After Vivosorb and Epifilm Application
(Sage Publications inc, 2021) Yilmaz, Mahmut Sinan; Sahin, Elvan; Kaymaz, Recep; Altunkaynak, Berrin Zuhal; Akidil, Ayse Oznur; Yanar, Sevinc; Guven, Mehmet; Histoloji ve Embriyoloji / Histology and Embriology
Background: Untreated traumatic tympanic membrane perforations (TMPs) may lead to permanent perforations and hearing loss. There are many materials that have been previously used for repairing the TMPs. Aims and Objectives: The purpose of this study is to evaluate the clinical and histological effects of Vivosorb (Vv) and Epifilm on healing of TMPs in a rat model. Material and Methods: The posterior-inferior quadrant of the tympanic membranes (TMs) in right ears of 14 rats was perforated using a 20-g needle and then the animals were randomly divided into 2 equal groups (n = 7). The perforated right TMs were treated with either Vv (Vv group) or Epifilm (Ep group). The left TMs of 7 rats were perforated in same way and allowed to close spontaneously without any topical material applications (spontaneous closure group as sham control, SC). The left tympanic membranes of the other 7 rats were not perforated and used as normal controls (NC group). On postoperative 15th day, tympanic bullas were extracted from killed rats and examined morphometrically and histopathologically. Results: Perforation closure rate was 85.7% (6/7) in both Vv and SC groups. Perforations of Ep group closed in 7/7 (100%) ears. The thicknesses of the perforated membranes were increased in SC and especially Vv groups. Also, connective tissue fibrosis, blood clots, and epithelial degenerations were detected in SC and Vv groups. The mean fibroblastic reaction scores of Vv, Ep, and SC groups were 2.14(+), 0.57(+), and 1.71(+) respectively, on comparison with NC group. The mean neovascularization score was 1.42(+) in Vv group, 0.14(+) in Ep group, and 0.57(+) in SC group. Conclusion and Significance: Vivosorb and especially Epifilm can improve the healing process in traumatic TMPs and additionally, Epifilm might be more preferred for the treatment of TMPs because of causing lesser fibrosis.
Citation Count: 4
The morphometrical and immunohistochemical investigation of the effect of topiramate on liver and the role of neuropeptide Y receptor in an obese female rat
(Comenius Univ, 2020) Yahyazadeh, A.; Altunkaynak, B. Z.; Alkan, I; Histoloji ve Embriyoloji / Histology and Embriology
OBJECTIVE: We aimed to investigate the possible effect of topiramate (TOP, 0.02 mg/kg/day) on the livers in a high-fat diet (HFD)-induced obesity rat model. The other objective was to evaluate the relationship between TOP administration and NPY level using anti-NPY1R antibody. METHODS: Twenty-four adult female Wistar albino rats were randomly assigned into four equal groups as follow: control (CONT), obese (OBS), TOP, and OBS+TOP. All liver samples were investigated using the stereological analysis, as well as immunohistochemical and histopathological examination. RESULTS: The total number of hepatocytes was significantly decreased in the OBS+TOP group compared to the CONT group or the OBS group (p < 0.05). We found a significant increase in the mean volume of liver in the OBS group compared to the CONT group (p < 0.05). Also, the mean volume of liver was significantly decreased in the OBS+TOP group compared to the OBS group (p < 0.05). CONCLUSION: Taken together, our findings suggest that decreased liver volume is possibly attributed to TOP administration via setting the NPY level in the obese rats. Further, the side effects of TOP in combination with health risk of obesity may have led to an increase in hepatotoxicity and the subsequent hepatocyte loss (Fig. 7, Ref. 56). Text in PDF www.elis.sk
Citation Count: 1
Applications of various stereological tools for estimation of biological tissues
(Wiley, 2023) Warille, Aymen A.; Kocaman, Adem; Elamin, Abdalla A.; Mohamed, Hamza; El Elhaj, Abubaker; Altunkaynak, Berrin Zuhal; Histoloji ve Embriyoloji / Histology and Embriology
To provide concise and brief important stereological application methods and techniques for estimating biological tissues. Stereology studies the quantity of biological tissue using little practice and the low price of counting and preparing tissue slices to obtain direct and accurate results. Since their establishment, the stereological techniques underwent much improvement, thus allowing more precise analysis of target structures using various approaches. Using stereological tools, advances in stereological techniques made the target tissues or organs represented by 2D instead of 3D dimensions. Process tools estimate volume, area and length. According to the exciting tissue and aims, the stereological tools perform differently. This review summarizes various stereological tools and techniques, providing brief information about the orientation method, slicer probe method, Delesse's principle, Cavalieri principle, disector, fractionator, nucleator, virtual cycloids and saucer, which are described in detail.
Citation Count: 14
Biochemical, immunohistochemical and morphometrical investigation of the effect of thymoquinone on the rat testis following exposure to a 900-MHz electromagnetic field
(Elsevier Gmbh, 2020) Yahyazadeh, Ahmad; Altunkaynak, Berrin Zuhal; Kaplan, Suleyman; Histoloji ve Embriyoloji / Histology and Embriology
Long-term use of cell phones emitting electromagnetic fields (EMFs) have raised concerns regarding public health in recent year. We aimed to investigate the possible effects of 900 MHz EMF exposure (60 min/day for 28 days) on the rat testis. Another objective was to determine whether the deleterious effect of EMF radiation would be reduced by the administration of thymoquinone (TQ) (10 mg/kg/day). Twenty-four male adult Wistar albino rats were randomly selected, then assigned into four groups as followControl, EMF, TQ and EMF + TQ. Testicular samples were analyzed using histological, stereological, biochemical and immunohistochemical techniques. Total numbers of primary spermatocytes and spermatids as well as Leydig cells were significantly decreased in the EMF group compared to the Control group (p < 0.05). In the EMF + TQ group, the total number of primary spermatocytes was significantly increased compared to the EMF group (p < 0.05). Superoxide dismutase (SOD) activity was significantly increased in the EMF group compared to the Control group (p< 0.05). Also, serum testosterone levels and wet weight of testes were significantly decreased in the EMF group compared to the Control group (p < 0.05). Our findings suggested that exposure to a 900 MHz EMF had adverse effects on rat testicular tissue and that the administration of TQ partially mitigated testicular oxidative damages caused by EMF radiation.
Citation Count: 0
Imiquimod Inhibits Proliferation of Serous Epithelial Ovarian Cancer Cells In Vitro: A Preliminary Study
(Springer india, 2020) Kokcu, Arif; Alper, Tayfun; Ogur, Gonul; Akar, Omer Salih; Ozdes, Emel Kurtoglu; Altunkaynak, Berrin Zuhal; Histoloji ve Embriyoloji / Histology and Embriology
Purpose Imiquimod, known as positive immune response modifier and stimulates local cytokine induction, has been used in therapy of genital warts via increasing local interferon and reducing human papillomavirus production. We aimed to investigate whether imiquimod has any effect on the proliferation of serous epithelial ovarian cancer cells in vitro. Methods The study was designed in two stages. The first stage was designed to evaluate co-culturing of serous epithelial ovarian cancer cells with the drug imiquimod versus cancer cells cultured with no drug. The second stage of the study was initiated with primary ovarian cancer cell culture growth. Imiquimod was applied in increasing concentrations to flasks full of each kind of cells. Also, histomorphometrical evaluation was made using an unbiased counting frame. Results Treatment of the primary cancer cell cultures with imiquimod in concentrations of 2.5 mu g/ml and 5.0 mu g/ml did not result in a significant effect on cell proliferation and the cell proliferation continued. Cell proliferation stopped and the cells detached at concentrations of 7.5 mu g/ml, especially 10.0 mu g/ml, 12.5 mu g/ml, and 25.0 mu g/ml, within 2-3 days after exposure to the drug. The anti-proliferative effect of imiquimod reached a maximum level at a concentration of 12.5 mu g/ml. Conclusions Imiquimod has a dose-dependent anti-proliferative impact on serous epithelial ovarian cancer cells in vitro.
Citation Count: 0
Investigation of the Relationship Between HMGB1 and Obesity in the Adrenal Gland
(2022) Muhammed ERDAL; Işınsu Aydın Alkan; Emin Oztas; Berrin Zuhal ALTUNKAYNAK; Adem KOCAMAN; Histoloji ve Embriyoloji / Histology and Embriology
Aim: The interaction between obesity and increased production of pro-inflammatory cytokines results the existence of inflammation HMGB1 secreted from the adrenal gland can play a role in inflammation pathways. The aim of this study is to explain the link between HMGB1 and obesity in the adrenal gland. Material and Methods: In this study; eighteen female Wistar Albino rats were divided into two groups: untreated control group (n=8) and obese group (n=10). The rats in obese group were fed with high fat diet for ten weeks. Morphometric parameters of adrenal gland were assessed by using stereological techniques. The expression of high mobility group box protein 1 (HMGB1) in adrenal gland was evaluated. Results: At the end of the analyses; mean volumes of zona fasciculate, zona reticularis, and medulla were significantly increased in obese group. Also, the number of HMGB1 stained cells was significantly increased in the obese group in comparison to control group.Conclusion: The results suggest that obesity may be one of the reasons of inflammation and hypertrophy in the adrenal gland. HMGB1 may provide a novel perspective into the anti-inflammatory therapeutic strategies in obese patients.
Citation Count: 7
Neuroprotective efficacy of luteolin on a 900-MHz electromagnetic field-induced cerebellar alteration in adult male rat
(Elsevier, 2020) Yahyazadeh, Ahmad; Altunkaynak, Berrin Zuhal; Histoloji ve Embriyoloji / Histology and Embriology
The adverse health consequences of exposure to electromagnetic field emitted from cell phone has recently raised public concerns worldwide. Also, the Global System for Mobile Communications (GSM) standard that operates in 900 MHz frequency is the most popular. Therefore, we aimed to investigate the adverse effect of exposure to 900 MHz EMF (1 h/day) on the cerebella of 12-week-old rats. We also evaluated the protective activity of luteolin (20 mu g/kg/day) against possible biological change in the cerebellar tissues exposed to EMF. Twenty-four male wistar albino rats were randomly assigned into four group of six rats: Control, EMF, EMF + luteolin, luteolin. Serological and biochemical analyses, as well as histopathological examination were performed on all cerebellar samples. We found that SOD (superoxide dismutase) level was significantly increased in the EMF group compared to the control group (p < 0.05). To the contrary, decreased SOD activity was detected in the EMF + luteolin group compared to control group (p < 0.05). The total number of Purkinje and granular cells was significantly decreased in the EMF group compared to the control group (p < 0.05). In the EMF + luteolin group, the total number of Purkinje and granular cells was significantly higher than the EMF group (p < 0.05). Histopathological evaluation also showed destructive damage to the architectures of cerebellar tissues. Our results suggest that exposure to EMF may cause cellular damage to the rat cerebellum. Further, the improvement of cerebellar damage may have resulted from antioxidant efficacy of luteolin by alleviating oxidative stress.

Altunkaynak, Berrin Zühal

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23

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