Altunkaynak, Berrin Zühal
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Name Variants
Berrin Z. Altunkaynak
Berrin Zühal, Altunkaynak
Altunkaynak, Berrin
ALTUNKAYNAK Berrin Zühal
Altunkaynak, Berrin Zühal
Berrin Zühal ALTUNKAYNAK
Altunkaynak, Zuhal
Altunkaynak Berrin Zuhal
Altunkaynak, B.
Altunkaynak Berrin Zühal
B. Zühal Altunkaynak
B. Z. ALTUNKAYNAK
ALTUNKAYNAK Berrin Zuhal
Berrin Zühal Altunkaynak
Zuhal Altunkaynak B.
Berrin Zuhal Altunkaynak
B. Zuhal Altunkaynak
Altunkaynak B.
Altunkaynak, Zühal
B. Z. Altunkaynak
Berrin Zuhal ALTUNKAYNAK
Altunkaynak, Z.
Altunkaynak, B. Z.
Altunkaynak, Berrin Zuhal
Altunkaynak,B.Z.
Berrin Zühal, Altunkaynak
Altunkaynak, Berrin
ALTUNKAYNAK Berrin Zühal
Altunkaynak, Berrin Zühal
Berrin Zühal ALTUNKAYNAK
Altunkaynak, Zuhal
Altunkaynak Berrin Zuhal
Altunkaynak, B.
Altunkaynak Berrin Zühal
B. Zühal Altunkaynak
B. Z. ALTUNKAYNAK
ALTUNKAYNAK Berrin Zuhal
Berrin Zühal Altunkaynak
Zuhal Altunkaynak B.
Berrin Zuhal Altunkaynak
B. Zuhal Altunkaynak
Altunkaynak B.
Altunkaynak, Zühal
B. Z. Altunkaynak
Berrin Zuhal ALTUNKAYNAK
Altunkaynak, Z.
Altunkaynak, B. Z.
Altunkaynak, Berrin Zuhal
Altunkaynak,B.Z.
Job Title
Prof.Dr.
Email Address
zuhal.altunkaynak@okan.edu.tr
ORCID ID
Scopus Author ID
Turkish CoHE Profile ID
Google Scholar ID
WoS Researcher ID
Scholarly Output
31
Articles
28
Citation Count
0
Supervised Theses
0
31 results
Scholarly Output Search Results
Now showing 1 - 10 of 31
Article Citation Count: 4Protective effect of melatonin on the rat lung following exposure to 900-MHz electromagnetic field: a stereological and histopathological study(Ondokuz Mayis Universitesi, 2021) Yahyazadeh,A.; Kivrak,E.G.; Koç,G.E.; Altunkaynak,B.Z.; Histoloji ve Embriyoloji / Histology and EmbriologyLong-term use of cell phone emitting electromagnetic field (EMF) has increased concerns regarding histopathological change in vital organs. Our present study was aimed to investigate the effect of 900 megahertz (MHz) EMF on the rat lungs, as well as the possible efficacy of melatonin (MEL) on lung tissues. Fifteen female Wistar albino rats were randomly selected and assigned into five groups as follow: control (CONT), SHAM, EMF, melatonin (MEL) and EMF+MEL group. Subsequently, female rats were then mated, and pregnant rats underwent the experimental application for 21 days. After parturition, 6 pups (2 pups from each mother) were randomly chosen and maintained for 4 weeks. At the end of the 4th week, the lung tissues of all groups were used for the stereological analysis and histopathological examination. We found that the mean volumes of the alveoli, bronchioles and blood vessels were significantly lower in the EMF group compared to the control group (p<0.05). In the EMF+MEL group, the mean volumes of the alveoli, bronchioles and blood vessels were significantly increased compared to the EMF group. Our histopathological results showed marked change in the lung tissues. We speculated that exposure to EMF caused the damage to the rat lung tissues, and that MEL administration alleviated 900 MHz EMF-induced complications. © 2021 Ondokuz Mayis Universitesi. All rights reserved.Article Citation Count: 10Histological Study of The Healing of Traumatic Tympanic Membrane Perforation After Vivosorb and Epifilm Application(Sage Publications inc, 2021) Yilmaz, Mahmut Sinan; Sahin, Elvan; Kaymaz, Recep; Altunkaynak, Berrin Zuhal; Akidil, Ayse Oznur; Yanar, Sevinc; Guven, Mehmet; Histoloji ve Embriyoloji / Histology and EmbriologyBackground: Untreated traumatic tympanic membrane perforations (TMPs) may lead to permanent perforations and hearing loss. There are many materials that have been previously used for repairing the TMPs. Aims and Objectives: The purpose of this study is to evaluate the clinical and histological effects of Vivosorb (Vv) and Epifilm on healing of TMPs in a rat model. Material and Methods: The posterior-inferior quadrant of the tympanic membranes (TMs) in right ears of 14 rats was perforated using a 20-g needle and then the animals were randomly divided into 2 equal groups (n = 7). The perforated right TMs were treated with either Vv (Vv group) or Epifilm (Ep group). The left TMs of 7 rats were perforated in same way and allowed to close spontaneously without any topical material applications (spontaneous closure group as sham control, SC). The left tympanic membranes of the other 7 rats were not perforated and used as normal controls (NC group). On postoperative 15th day, tympanic bullas were extracted from killed rats and examined morphometrically and histopathologically. Results: Perforation closure rate was 85.7% (6/7) in both Vv and SC groups. Perforations of Ep group closed in 7/7 (100%) ears. The thicknesses of the perforated membranes were increased in SC and especially Vv groups. Also, connective tissue fibrosis, blood clots, and epithelial degenerations were detected in SC and Vv groups. The mean fibroblastic reaction scores of Vv, Ep, and SC groups were 2.14(+), 0.57(+), and 1.71(+) respectively, on comparison with NC group. The mean neovascularization score was 1.42(+) in Vv group, 0.14(+) in Ep group, and 0.57(+) in SC group. Conclusion and Significance: Vivosorb and especially Epifilm can improve the healing process in traumatic TMPs and additionally, Epifilm might be more preferred for the treatment of TMPs because of causing lesser fibrosis.Article Citation Count: 0Investigation of the Relationship Between HMGB1 and Obesity in the Adrenal Gland(2022) Muhammed ERDAL; Işınsu Aydın Alkan; Emin Oztas; Berrin Zuhal ALTUNKAYNAK; Adem KOCAMAN; Histoloji ve Embriyoloji / Histology and EmbriologyAim: The interaction between obesity and increased production of pro-inflammatory cytokines results the existence of inflammation HMGB1 secreted from the adrenal gland can play a role in inflammation pathways. The aim of this study is to explain the link between HMGB1 and obesity in the adrenal gland. Material and Methods: In this study; eighteen female Wistar Albino rats were divided into two groups: untreated control group (n=8) and obese group (n=10). The rats in obese group were fed with high fat diet for ten weeks. Morphometric parameters of adrenal gland were assessed by using stereological techniques. The expression of high mobility group box protein 1 (HMGB1) in adrenal gland was evaluated. Results: At the end of the analyses; mean volumes of zona fasciculate, zona reticularis, and medulla were significantly increased in obese group. Also, the number of HMGB1 stained cells was significantly increased in the obese group in comparison to control group.Conclusion: The results suggest that obesity may be one of the reasons of inflammation and hypertrophy in the adrenal gland. HMGB1 may provide a novel perspective into the anti-inflammatory therapeutic strategies in obese patients.Article Citation Count: 7Is melatonin, leptin or their combination more effective on oxidative stress and folliculogenesis in the obese rats?(Taylor & Francis inc, 2020) Kirikci, Gamze; Altunkaynak, Berrin Zuhal; Kaplan, Suleyman; Histoloji ve Embriyoloji / Histology and EmbriologyIn this study, we evaluated the effects of melatonin (Mel), leptin (Lep) or melatonin and leptin treatment on ovaries in control and obese rats. The animals were divided into control (NC), melatonin (NM), leptin (NL), melatonin?leptin (NML), obese (OC), obese?melatonin (OM), obese?leptin (OL), obese?melatonin?leptin (OML) groups. Body weights, peri-ovarian fat pads, volumetric parameters and numerical values of follicles were estimated. Also, the LH receptor (LHr) immune-positivity, catalase (CAT) and the myeloperoxidase (MPO) levels were determined. The body weight and peri-ovarian fat pads were significantly decreased following Mel (p?Article Citation Count: 1Evaluation of the protective effects of folic acid on the lung exposed to 900-MHZ electromagnetic field: A stereological and histopathological study(Ondokuz Mayis Universitesi, 2022) Tüfekçi,K.K.; Bakirhan,E.G.; Altunkaynak,B.Z.; Histoloji ve Embriyoloji / Histology and EmbriologyThere is strong scientific evidence that radio frequency (RF) radiation is harmful to life. Exposure to radiation may cause lung toxicity and respiratory disorders. Folic acid (FA) is one of the powerful antioxidants that minimize oxidative stress in the biological system. In this study, we evaluated the effectiveness of the FA against the EMF-induced potential negative effects on the lung. Twenty-four male Wistar albino rats were divided into the four groups; control group (Cont), electromagnetic field group (EMF), FA treated group (FA), and electromagnetic field exposure + FA treated group (EFA). After the routine histological procedures, volumes of the alveoli, bronchioles and blood vessels have been estimated by the Cavalieri principle. It was found that a significant decrease in the mean volume of alveoli, bronchioles and blood vessels in EMF group in comparison of the Cont group (p<0.01). Besides this, histopathological analysis demonstrated that there was impaired lung structure, shrunken alveoli, and increased thickness of the alveolar wall in the EMF group sections. In the EFA group, significant protective effects were observed in the structures volumes and histopathology (p<0.01). These findings corresponded with the antioxidant effect of FA treatment. Our results suggest that FA protected alveoli, bronchioles, and blood vessels against EMF-induced lung injury. Thus FA has the potential to be a therapeutic agent. © 2022 Ondokuz Mayis Universitesi. All rights reserved.Article Citation Count: 2Protective effect of indole-3-carbinol on testis of a high fat diet induced obesity(Taylor & Francis Ltd, 2023) Tufek, Nur Hande; Yahyazadeh, Ahmad; Altunkaynak, Berrin Zuhal; Histoloji ve Embriyoloji / Histology and EmbriologyWe investigated the effects of obesity caused by a high fat diet (HFD) on rat testes and evaluated the possible protective effects of indole-3-carbinol (IND). We used 24 8-10-week-old 200 g male rats randomly assigned to 4 groups: non-obese control (NC), obese control (OC), non-obese IND group (NI), obese + IND group (OI). Testis samples were examined using stereological, immunohistochemical, biochemical and histological methods. The number of spermatogenic cells, Leydig cells, mean volume of testes and seminiferous tubules was significantly decreased in the OC group compared to the NC group, but these values were increased significantly in the OI group compared to the OC group. We found a significant increase in catalase and myeloperoxidase activities in the OC group compared to the NC group. In the OI group, catalase and myeloperoxidase levels were decreased compared to the OC group. TUNEL-positive cells also were increased in the OC group compared to the NC group (p < 0.05), but these were fewer in the OI group than the OC group. We found marked morphological changes in testicular tissues between the NC and OC groups, as well as between the OI and OC groups. We found that HFD induced obesity was detrimental to rat testes and that administration of IND ameliorated testicular changes caused by obesity.Article Citation Count: 13Investigation of the neuroprotective effects of thymoquinone on rat spinal cord exposed to 900 MHz electromagnetic field(Elsevier, 2019) Yahyazadeh, Ahmad; Altunkaynak, Berrin Zuhal; Histoloji ve Embriyoloji / Histology and EmbriologyExposure to electromagnetic field in long-term use of cell phones has increased concerns about serious health problems. Our aim was to survey the possible effects of electromagnetic field radiation (60 min/day for 28 days) on the spinal cords of 12 weeks old rats. Further, we investigated whether the administration of thymoquinone (10 mg/kg/day) would protect the spinal cord tissue against the adverse effects of electromagnetic field or not. Twenty-four adult male Wistar albino rats were assigned randomly into four groups: control, electromagnetic field, thymoquinone and electromagnetic field + thymoquinone. The cervical spinal cords of all rats was evaluated using the stereological, biochemical and histological methods. The number of motor neurons were reduced in the electromagnetic field group compared to the control group (p < 0.05). Superoxide dismutase level was higher in the electromagnetic field group compared to the control group (p < 0.05). In the electromagnetic field + thymoquinone group, we found an increase in the number of motor neurons and decrease in superoxide dismutase activity compared to the electromagnetic field group (p < 0.05). Our histological findings also exhibit the remarkable architectural alterations. We speculated that electromagnetic field radiation induced the morphological and biochemical damage to the spinal cord tissue of rats. Administration of antioxidant, thymoquinone, also ameliorated such complications caused by electromagnetic field.Article Citation Count: 4The morphometrical and immunohistochemical investigation of the effect of topiramate on liver and the role of neuropeptide Y receptor in an obese female rat(Comenius Univ, 2020) Yahyazadeh, A.; Altunkaynak, B. Z.; Alkan, I; Histoloji ve Embriyoloji / Histology and EmbriologyOBJECTIVE: We aimed to investigate the possible effect of topiramate (TOP, 0.02 mg/kg/day) on the livers in a high-fat diet (HFD)-induced obesity rat model. The other objective was to evaluate the relationship between TOP administration and NPY level using anti-NPY1R antibody. METHODS: Twenty-four adult female Wistar albino rats were randomly assigned into four equal groups as follow: control (CONT), obese (OBS), TOP, and OBS+TOP. All liver samples were investigated using the stereological analysis, as well as immunohistochemical and histopathological examination. RESULTS: The total number of hepatocytes was significantly decreased in the OBS+TOP group compared to the CONT group or the OBS group (p < 0.05). We found a significant increase in the mean volume of liver in the OBS group compared to the CONT group (p < 0.05). Also, the mean volume of liver was significantly decreased in the OBS+TOP group compared to the OBS group (p < 0.05). CONCLUSION: Taken together, our findings suggest that decreased liver volume is possibly attributed to TOP administration via setting the NPY level in the obese rats. Further, the side effects of TOP in combination with health risk of obesity may have led to an increase in hepatotoxicity and the subsequent hepatocyte loss (Fig. 7, Ref. 56). Text in PDF www.elis.skReview Citation Count: 1Applications of various stereological tools for estimation of biological tissues(Wiley, 2023) Warille, Aymen A.; Kocaman, Adem; Elamin, Abdalla A.; Mohamed, Hamza; El Elhaj, Abubaker; Altunkaynak, Berrin Zuhal; Histoloji ve Embriyoloji / Histology and EmbriologyTo provide concise and brief important stereological application methods and techniques for estimating biological tissues. Stereology studies the quantity of biological tissue using little practice and the low price of counting and preparing tissue slices to obtain direct and accurate results. Since their establishment, the stereological techniques underwent much improvement, thus allowing more precise analysis of target structures using various approaches. Using stereological tools, advances in stereological techniques made the target tissues or organs represented by 2D instead of 3D dimensions. Process tools estimate volume, area and length. According to the exciting tissue and aims, the stereological tools perform differently. This review summarizes various stereological tools and techniques, providing brief information about the orientation method, slicer probe method, Delesse's principle, Cavalieri principle, disector, fractionator, nucleator, virtual cycloids and saucer, which are described in detail.Article Citation Count: 14Biochemical, immunohistochemical and morphometrical investigation of the effect of thymoquinone on the rat testis following exposure to a 900-MHz electromagnetic field(Elsevier Gmbh, 2020) Yahyazadeh, Ahmad; Altunkaynak, Berrin Zuhal; Kaplan, Suleyman; Histoloji ve Embriyoloji / Histology and EmbriologyLong-term use of cell phones emitting electromagnetic fields (EMFs) have raised concerns regarding public health in recent year. We aimed to investigate the possible effects of 900 MHz EMF exposure (60 min/day for 28 days) on the rat testis. Another objective was to determine whether the deleterious effect of EMF radiation would be reduced by the administration of thymoquinone (TQ) (10 mg/kg/day). Twenty-four male adult Wistar albino rats were randomly selected, then assigned into four groups as followControl, EMF, TQ and EMF + TQ. Testicular samples were analyzed using histological, stereological, biochemical and immunohistochemical techniques. Total numbers of primary spermatocytes and spermatids as well as Leydig cells were significantly decreased in the EMF group compared to the Control group (p < 0.05). In the EMF + TQ group, the total number of primary spermatocytes was significantly increased compared to the EMF group (p < 0.05). Superoxide dismutase (SOD) activity was significantly increased in the EMF group compared to the Control group (p< 0.05). Also, serum testosterone levels and wet weight of testes were significantly decreased in the EMF group compared to the Control group (p < 0.05). Our findings suggested that exposure to a 900 MHz EMF had adverse effects on rat testicular tissue and that the administration of TQ partially mitigated testicular oxidative damages caused by EMF radiation.
