The value of C-reactive protein-to-albumin ratio in predicting long-term mortality among HFrEF patients with implantable cardiac defibrillators

dc.authorscopusid57056413300
dc.authorscopusid56872862000
dc.authorscopusid57221697878
dc.authorscopusid57219457162
dc.authorscopusid57219456638
dc.authorscopusid57203911770
dc.authorscopusid23038080400
dc.contributor.authorÇinier,G.
dc.contributor.authorHayıroğlu,M.İ.
dc.contributor.authorKolak,Z.
dc.contributor.authorTezen,O.
dc.contributor.authorYumurtaş,A.Ç.
dc.contributor.authorPay,L.
dc.contributor.authorGürkan,K.
dc.date.accessioned2024-05-25T12:34:03Z
dc.date.available2024-05-25T12:34:03Z
dc.date.issued2021
dc.departmentOkan Universityen_US
dc.department-tempÇinier G., Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey; Hayıroğlu M.İ., Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey; Kolak Z., Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey; Tezen O., Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey; Yumurtaş A.Ç., Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey; Pay L., Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey; Eren S., Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey; Çetin T., Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey; Özcan S., Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey; Türkkan C., Department of Cardiology, Okan University Hospital, Istanbul, Turkey; Özbilgin N., Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey; Tekkeşin A.İ., Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey; Alper A.T., Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey; Gürkan K., Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkeyen_US
dc.description.abstractBackground: Patients with heart failure with reduced ejection fraction (HFrEF) who received implantable cardiac defibrillator (ICD) still remain at high risk due to pump failure and prevalent comorbid conditions. The primary aim of this research was to evaluate the predictive value of C-reactive protein-to-albumin ratio (CAR) for all-cause mortality among patients with HFrEF despite ICD implantation. Materials and methods: Those who were implanted ICD for HFrEF in our institution between 2009 and 2019 were included. Data were extracted from hospital's database. CAR was calculated as ratio of C-reactive protein (CRP) to serum albumin concentration. Patients were grouped into tertiles in accordance with CAR at the time of the implantation. During follow-up duration of 38 [17-77] months, survival times of tertiles were compared by using Kaplan-Meier survival method. Forward Cox proportional regression model was used for multivariable analysis. Results: Thousand and eleven patients constituted the study population. Ischaemic cardiomyopathy was the primary diagnosis in 92.3%, and ICD was implanted for the primary prevention among 33.9% of patients. Of those, 14.5% died after the discharge. Patients in tertile 3 (T3) had higher risk of mortality (4.2% vs 11.0% vs 28.5%) compared with those in other tertiles. Multivariable analysis revealed that when patients in T1 were considered as the reference, both those in T2 and those in T3 had independently higher risk of all-cause mortality. This finding was consistent in the unadjusted and adjusted multivariable models. Conclusion: Among patients with HFrEF and ICD, elevated CAR increased the risk of all-cause mortality at long term. © 2021 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltden_US
dc.identifier.citation20
dc.identifier.doi10.1111/eci.13550
dc.identifier.issn0014-2972
dc.identifier.issue8en_US
dc.identifier.pmidPubMed:33778950
dc.identifier.scopus2-s2.0-85103223398
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1111/eci.13550
dc.identifier.urihttps://hdl.handle.net/20.500.14517/2533
dc.identifier.volume51en_US
dc.identifier.wosqualityQ1
dc.language.isoen
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofEuropean Journal of Clinical Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectC-reactive protein-to-albumin ratioen_US
dc.subjectheart failure with reduced ejection fractionen_US
dc.subjectimplantable cardiac defibrillatoren_US
dc.subjectmortalityen_US
dc.titleThe value of C-reactive protein-to-albumin ratio in predicting long-term mortality among HFrEF patients with implantable cardiac defibrillatorsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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