Comparison of interleukin-6, oxidant and antioxidant levels in the kidneys of the trained and untrained rats following exhaustive exercise

dc.authorscopusid 57996739600
dc.authorscopusid 18433767500
dc.authorscopusid 35111056900
dc.authorscopusid 55880573200
dc.contributor.author Ersever, E. M.
dc.contributor.author Aral, A.
dc.contributor.author Goktas, T.
dc.contributor.author Pinar, L.
dc.contributor.other Fizyoloji / Physiology
dc.date.accessioned 2024-05-25T11:25:59Z
dc.date.available 2024-05-25T11:25:59Z
dc.date.issued 2023
dc.department Okan University en_US
dc.department-temp [Ersever, E. M.] Saglik Bilimleri Univ, Dept Phys Med & Rehabil, Ankara Training & Res Hosp, TR-06600 Ankara, Turkiye; [Aral, A.] Izmir Demokrasi Univ, Gursel Aksel Bulvari 14, TR-35140 Izmir, Turkiye; [Goktas, T.] Lokman Hekim Univ, Sogutozu 2179 Sk 6, TR-06510 Ankara, Turkiye; [Pinar, L.] Okan Univ, Tuzla Campus, TR-34959 Istanbul, Turkiye en_US
dc.description.abstract In this study, the cytokine response (interleukin-6; IL-6), free oxygen radicals which are claimed to be responsible for the damage in the kidney tissue of exercise-trained rats and untrained-rats, and antioxidant levels were investigated after being forced to an exhausting run. Forty male Wistar albino rats were assigned to the following groups: sedentary controls (C); untrained animals that acutely completed the exhaustive exercise and were sacrificed immediately after exhaustion (UT-i) or 1 day after exhaustion (UT-1); and long-term trained animals that completed the exhaustive exercise and were sacrificed immediately after exhaustion (T-i) or 1 day after exhaustion (T-1). In UT-i and 1 day after exhaustion (T-1) groups, total oxidant status levels were increased compared to controls (P<0.05). IL-6, which is reported to have an anti-inflammatory effect in exercise, did not increase in untrained group immediately, but started to increase 1 day after exhaustion compared to controls. IL-6 levels were significantly increased in the T-i and T-1 groups compared to the control and UT-i groups (P<0.05). The level of total antioxidant status did not show a significant increase in the UT-i group but started to rise after exhaustion the T-1 group. IL-6 levels were significantly increased in the T-i and T-1 groups compared to the control, UT-i, and UT-1 groups (P<0.05). As a result, while oxidant stress and antioxidant mechanism increased immediately in the trained group, IL-6 increased significantly immediately and 1 day later. In the untrained group, however, an increase was observed in oxidant stress, antioxidant mechanism, and IL-6 levels after 1 day. en_US
dc.identifier.citationcount 0
dc.identifier.doi 10.3920/CEP220026
dc.identifier.endpage 174 en_US
dc.identifier.issn 1755-2540
dc.identifier.issn 1755-2559
dc.identifier.issue 2 en_US
dc.identifier.scopus 2-s2.0-85153892347
dc.identifier.scopusquality Q4
dc.identifier.startpage 169 en_US
dc.identifier.uri https://doi.org/10.3920/CEP220026
dc.identifier.uri https://hdl.handle.net/20.500.14517/951
dc.identifier.volume 19 en_US
dc.identifier.wos WOS:000963678200010
dc.institutionauthor Pınar L.
dc.language.iso en
dc.publisher Wageningen Academic Publishers en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 0
dc.subject exhaustive exercise en_US
dc.subject kidney en_US
dc.subject oxidative stress en_US
dc.subject antioxidants en_US
dc.subject cytokines en_US
dc.title Comparison of interleukin-6, oxidant and antioxidant levels in the kidneys of the trained and untrained rats following exhaustive exercise en_US
dc.type Article en_US
dc.wos.citedbyCount 0

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