Recent advances on anti-diabetic potential of pigmented phytochemicals in foods and medicinal plants

dc.authorscopusid 55754670700
dc.authorscopusid 57211079661
dc.authorscopusid 55628003500
dc.authorscopusid 56437916600
dc.authorscopusid 23666338900
dc.contributor.author Kamiloglu, Senem
dc.contributor.author Gunal-Koroglu, Deniz
dc.contributor.author Ozdal, Tugba
dc.contributor.author Tomas, Merve
dc.contributor.author Capanoglu, Esra
dc.date.accessioned 2024-09-11T07:40:44Z
dc.date.available 2024-09-11T07:40:44Z
dc.date.issued 2024
dc.department Okan University en_US
dc.department-temp [Kamiloglu, Senem] Bursa Uludag Univ, Fac Agr, Dept Food Engn, TR-16059 Gorukle, Bursa, Turkiye; [Kamiloglu, Senem] Bursa Uludag Univ, Sci & Technol Applicat & Res Ctr BITUAM, TR-16059 Bursa, Turkiye; [Gunal-Koroglu, Deniz; Tomas, Merve; Capanoglu, Esra] Istanbul Tech Univ, Fac Chem & Met Engn, Dept Food Engn, TR-34469 Istanbul, Turkiye; [Ozdal, Tugba] Istanbul Okan Univ, Fac Engn & Nat Sci, Dept Food Engn, TR-34959 I?stanbul, Turkiye en_US
dc.description.abstract Type 2 diabetes is marked by elevated blood sugar levels and linked to impaired insulin secretion and resistance to insulin. Researchers are continuously investigating different classes of phytochemicals including natural pigments for their potential direct or indirect advantages in the prevention and/or control of diabetes. In this review, clinical trials, animal studies, and cell culture models, as well as in vitro enzyme inhibition assays and in silico molecular docking studies were covered for pigmented phytochemicals including anthocyanins, carotenoids, betalains, chlorophylls, curcumin, and phycocyanins. Recent research has shown that the anti-diabetic effects of pigments include (1) inhibition of ROS formation, (2) downregulation of inflammatory response like inhibiting COX, or regulation of pro-inflammatory cytokines (TNF-alpha, IL-1 beta, IL-6), (3) regulation of multiple signal pathways such as NF-kappa B, AMPK, MAPK, (4) inhibition of cell apoptosis, according to the ratio of Bcl-2/Bax; and cell proliferation via PI3K/Akt pathways, and (5) digestive enzyme inhibition, such as alpha-amylase and alpha-glucosidase, among others. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.citationcount 0
dc.identifier.doi 10.1007/s11101-024-10014-4
dc.identifier.issn 1568-7767
dc.identifier.issn 1572-980X
dc.identifier.scopus 2-s2.0-85202643642
dc.identifier.scopusquality Q1
dc.identifier.uri https://doi.org/10.1007/s11101-024-10014-4
dc.identifier.uri https://hdl.handle.net/20.500.14517/6209
dc.identifier.wos WOS:001302280300001
dc.identifier.wosquality Q1
dc.language.iso en
dc.publisher Springer en_US
dc.relation.publicationcategory Diğer en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 2
dc.subject Diabetes en_US
dc.subject Anthocyanins en_US
dc.subject Carotenoids en_US
dc.subject Betalains en_US
dc.subject Chlorophylls en_US
dc.subject Curcumin en_US
dc.title Recent advances on anti-diabetic potential of pigmented phytochemicals in foods and medicinal plants en_US
dc.type Review en_US
dc.wos.citedbyCount 2

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