Mxenes in Combination Therapy: Chemo-Photothermal, Chemodynamic, and Photothermal/Photodynamic Therapies for Cancer Treatment and Antibacterial Applications

dc.authorscopusid 55992962200
dc.authorscopusid 56700291100
dc.authorscopusid 57202500098
dc.authorscopusid 35336983500
dc.authorscopusid 23483174100
dc.contributor.author Amoozadeh, Masoomeh
dc.contributor.author Zarepour, Atefeh
dc.contributor.author Khosravi, Arezoo
dc.contributor.author Iravani, Siavash
dc.contributor.author Zarrabi, Ali
dc.date.accessioned 2025-04-15T23:53:21Z
dc.date.available 2025-04-15T23:53:21Z
dc.date.issued 2025
dc.department Okan University en_US
dc.department-temp [Amoozadeh, Masoomeh] Univ Isfahan, Dept Chem, Esfahan, Iran; [Zarepour, Atefeh] Saveetha Univ, Saveetha Dent Coll & Hosp, Saveetha Inst Med & Tech Sci, Dept Res Analyt, Chennai 600077, India; [Khosravi, Arezoo] Istanbul Okan Univ, Fac Engn & Nat Sci, Dept Genet & Bioengn, TR-34959 Istanbul, Turkiye; [Iravani, Siavash] W Nazar ST,Boostan Ave, Esfahan, Iran; [Zarrabi, Ali] Istinye Univ, Fac Engn & Nat Sci, Dept Biomed Engn, TR-34396 Istanbul, Turkiye; [Zarrabi, Ali] Yuan Ze Univ, Grad Sch Biotechnol & Bioengn, Taoyuan, Taiwan en_US
dc.description.abstract Two-dimensional MXenes and their derivatives have attracted significant attention in recent years for their potential applications in combination therapies, specifically in chemo-photothermal, chemodynamic, and photothermal/photodynamic treatments. MXenes offer distinct advantages in combination therapies due to their exceptional electrical conductivity, hydrophilicity, large surface area, tunable surface chemistry, and ability to enhance drug delivery and therapeutic efficacy through multifunctional applications. By incorporating MXenes into combination therapies, researchers have demonstrated enhanced therapeutic efficacy through synergistic mechanisms that improve drug delivery, increase localized heating, and amplify the generation of reactive oxygen species, thereby effectively targeting and eliminating cancer cells or contaminations. However, stability in biological environments remains a primary concern, as degradation can compromise their therapeutic effectiveness and safety. Ensuring biocompatibility is crucial, since the introduction of MXenes and their composites may trigger immune responses or cytotoxicity. Moreover, optimizing the synthesis of high-quality MXenes with uniform properties remains a logistical challenge, affecting reproducibility and scalability for clinical applications. By consolidating existing knowledge and identifying future directions, this review aims to advance MXenebased combination chemo-photothermal, chemodynamic, and photothermal/photodynamic therapies for cancer treatment and antibacterial applications, ultimately paving the way for innovative strategies in biomedicine and personalized medicine. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1016/j.flatc.2025.100849
dc.identifier.issn 2452-2627
dc.identifier.scopus 2-s2.0-86000532949
dc.identifier.scopusquality Q1
dc.identifier.uri https://doi.org/10.1016/j.flatc.2025.100849
dc.identifier.uri https://hdl.handle.net/20.500.14517/7787
dc.identifier.volume 51 en_US
dc.identifier.wos WOS:001448356900001
dc.identifier.wosquality Q2
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Mxenes en_US
dc.subject Photothermal Therapy en_US
dc.subject Chemodynamic Therapy en_US
dc.subject Sonodynamic Therapy en_US
dc.subject Photodynamic Therapy en_US
dc.title Mxenes in Combination Therapy: Chemo-Photothermal, Chemodynamic, and Photothermal/Photodynamic Therapies for Cancer Treatment and Antibacterial Applications en_US
dc.type Article en_US

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