Momordica charantia Enhances Tendon Healing in Rats: An Experimental Study

dc.authorscopusid 57226175761
dc.authorscopusid 57054834700
dc.authorscopusid 57189903427
dc.authorscopusid 56797959500
dc.authorscopusid 15063935100
dc.authorscopusid 55898789300
dc.authorscopusid 7403238396
dc.contributor.author Erdoğan,F.
dc.contributor.author Kaplan,A.A.
dc.contributor.author Coşkun,H.S.
dc.contributor.author Altun,G.
dc.contributor.author Altunkaynak,B.Z.
dc.contributor.author Kelsaka,E.
dc.contributor.author Pişkin,A.
dc.date.accessioned 2024-09-11T07:42:57Z
dc.date.available 2024-09-11T07:42:57Z
dc.date.issued 2024
dc.department Okan University en_US
dc.department-temp Erdoğan F., Clinic of Orthopaedic and Traumatology, Sabuncuoğlu Şerafeddin Training and Research Hospital, Amasya, Turkey; Kaplan A.A., Department of Histology and Embryology, Faculty of Medicine, İstanbul Medipol University, Samsun, Turkey; Coşkun H.S., Department of Orthopaedic and Traumatology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey; Altun G., Department of Histology and Embryology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey; Altunkaynak B.Z., Department of Histology and Embryology, Faculty of Medicine, İstanbul Okan University, Istanbul, Turkey; Kelsaka E., Department of Anaesthesia and Reanimation, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey; Kaplan S., Department of Histology and Embryology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey, Nelson Mandela African Institution of Science and Technology, Arusha, Tanzania; Pişkin A., Department of Orthopaedic and Traumatology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey en_US
dc.description.abstract Momordica charantia (MC) is a traditional plant widely used since ancient times for wound healing. This study evaluated its potential effects on tendon healing. Adult male Wistar albino rats (n = 32, 8 rats in each group) were anesthetized, and their Achilles tendons were prepared for surgical procedures. Group 1 (Cont = control group) was not subjected to any surgery and was used as a control group for baseline values. Group 2 (PR = primary repair group) underwent primary repair (PR) with a monofilament suture after a full-thickness incision of the Achilles tendon. A full-thickness incision was also made to the Achilles tendon of group 3 (CT = collagen tube-administered group), followed by PR and collagen tube insertion. In group 4 (MC = M. charantia-administered group), 1 mL of MC extract was applied locally on the collagen tube in addition to the surgical procedure applied to group 3. The Achilles tendons were excised on the postoperative 40th day and examined stereologically, histologically, and bioinformatically. Data showed that the total volume of the collagen fibers was higher in MC and CT groups than in the PR group. The total volume of the tendon was decreased in MC and CT groups than in the Cont group. The ratios between the volumes of the collagen fibers and total tendon in the MC and CT groups were significantly different from PR, but not different from the Cont group. Additionally, MC improved tenoblastic activity, collagen production, and neovascularization. Bioinformatic interactions showed that the proteases of MC could trigger the signals playing a role on vasculogenesis, reducing inflammation, and contributing to tenoblast activation and collagen remodeling. MC extract ameliorates the healing of injured tendon and can provide satisfactory tendon repair. Further works are recommended to explore the healing capacity of MC. © 2023 S. Karger AG, Basel. en_US
dc.identifier.citationcount 0
dc.identifier.doi 10.1159/000533644
dc.identifier.endpage 315 en_US
dc.identifier.issn 1422-6405
dc.identifier.issue 4 en_US
dc.identifier.pmid 37586334
dc.identifier.scopus 2-s2.0-85195033171
dc.identifier.scopusquality Q2
dc.identifier.startpage 304 en_US
dc.identifier.uri https://doi.org/10.1159/000533644
dc.identifier.uri https://hdl.handle.net/20.500.14517/6276
dc.identifier.volume 213 en_US
dc.identifier.wosquality Q1
dc.language.iso en
dc.publisher S. Karger AG en_US
dc.relation.ispartof Cells Tissues Organs en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 0
dc.subject Bioinformatics en_US
dc.subject Momordica charantia en_US
dc.subject Rat en_US
dc.subject Stereology en_US
dc.subject Tendon healing en_US
dc.title Momordica charantia Enhances Tendon Healing in Rats: An Experimental Study en_US
dc.type Article en_US

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