The predictive value of PRECISE-DAPT score for long-term mortality in patients with acute coronary syndrome complicated by cardiogenic shock

dc.authoridÇetin, Mustafa/0000-0001-6342-436X
dc.authoridAKYUZ, SUKRU/0000-0003-2596-6875
dc.authorscopusid36103971300
dc.authorscopusid37099642500
dc.authorscopusid8835640500
dc.authorscopusid36678592800
dc.authorscopusid57221697878
dc.authorscopusid57217681171
dc.authorscopusid7101936231
dc.authorwosidÇetin, Mustafa/A-2919-2016
dc.contributor.authorAkyuz, Sukru
dc.contributor.authorAkyüz, Şükrü
dc.contributor.authorOnuk, Tolga
dc.contributor.authorYaylak, Baris
dc.contributor.authorKolak, Zeynep
dc.contributor.authorEren, Semih
dc.contributor.authorTanboga, Ibrahim Halil
dc.contributor.otherKardiyoloji / Cardiology
dc.contributor.otherKardiyoloji / Cardiology
dc.date.accessioned2024-05-25T11:27:53Z
dc.date.available2024-05-25T11:27:53Z
dc.date.issued2024
dc.departmentOkan Universityen_US
dc.department-temp[Akyuz, Sukru] Okan Univ, Fac Med, Dept Cardiol, Istanbul, Turkiye; [Calik, Ali Nazmi; Onuk, Tolga; Yaylak, Baris; Kolak, Zeynep; Eren, Semih; Mollaalioglu, Feyza] Univ Hlth Sci, Siyami Ersek Thorac & Cardiovasc Surg Training & R, Dept Cardiol, Istanbul, Turkiye; [Durak, Furkan] Ilhan Varank Sancaktepe Training & Res Hosp, Dept Cardiol, Istanbul, Turkiye; [Cetin, Mustafa] Recep Tayyip Erdogan Univ, Training & Res Hosp, Dept Cardiol, Rize, Turkiye; [Tanboga, Ibrahim Halil] Nisantasi Univ, Med Sch, Dept Biostat, Istanbul, Turkiye; [Tanboga, Ibrahim Halil] Hisar Intercontinental Hosp, Dept Cardiol, Istanbul, Turkiye; [Akyuz, Sukru] Okan Univ, Fac Med, Dept Cardiol, Elysium Elit Kosuyolu Block D1,Kadikoy, Istanbul, Turkiyeen_US
dc.descriptionÇetin, Mustafa/0000-0001-6342-436X; AKYUZ, SUKRU/0000-0003-2596-6875en_US
dc.description.abstractBackgroundBesides its primary clinical utility in predicting bleeding risk in patients with acute coronary syndrome (ACS), the PRECISE-DAPT (Predicting Bleeding Complications in Patients Undergoing Stent Implantation and Subsequent Dual Anti-Platelet Therapy) score may also be useful for predicting long-term mortality in ACS patients presenting with cardiogenic shock (CS) since several studies have reported an association between the score and certain cardiovascular conditions or events. The aim of the present study was to evaluate the utility of the PRECISE-DAPT score for predicting the long-term all-cause mortality in patients (n = 293) with ACS presenting with CS.MethodsThe PRECISE-DAPT score was calculated for each patient who survived in hospital, and the association with long-term mortality was studied. Median follow-up time was 2.7 years. The performance of the final model was determined with measurements of its discriminative power (Harrell's and Uno's C indices and time-dependent area under the receiver operating characteristic curve [AUC]) and predictive accuracy (coefficient of determination [R2] and likelihood ratio chi 2). Hazard ratios (HRs) were used to assess the relationship between the variables of the model and long-term all-cause death.ResultsAll-cause death occurred in 197 patients (67%). There was a positive association between the PRECISE-DAPT score (change from 17 to 38 was associated with an HR of 2.42 [95% CI: 1.59-3.68], R2 = 0.209, time-dependent AUC = 0.69) and the risk of death such that in the adjusted survival curve, the risk of mortality increased as the PRECISE-DAPT score increased.ConclusionThe PRECISE-DAPT score may be a useful easy-to-use tool for predicting long-term mortality in patients with ACS complicated by CS. HintergrundNeben seinem primaren klinischen Nutzen zur Vorhersage des Blutungsrisikos bei Patienten mit akutem Koronarsyndrom (ACS) konnte der PRECISE-DAPT-Score (Predicting Bleeding Complications in Patients Undergoing Stent Implantation and Subsequent Dual Anti-platelet Therapy) auch zur Vorhersage der Langzeitmortalitat bei ACS-Patienten nutzlich sein, bei denen es zum kardiogenen Schock (CS) kommt, denn in verschiedenen Studien wurde uber einen Zusammenhang zwischen dem Score und bestimmten kardiovaskularen Erkrankungen oder Ereignissen berichtet. Ziel der vorliegenden Studie war es, den Nutzen des PRECISE-DAPT-Scores bei der Vorhersage der Langzeitmortalitat aus samtlichen Ursachen bei Patienten (n = 293) mit ACS und CS zu untersuchen.MethodenDazu wurde der PRECISE-DAPT-Score fur jeden Patienten bestimmt, der im Krankenhaus uberlebte, und dann der Zusammenhang mit der Langzeitmortalitat wurde untersucht. Die mittlere Nachbeobachtungsdauer betrug 2,7 Jahre. Die Leistungsfahigkeit des endgultigen Modells wurde bestimmt anhand von Messungen seiner Trennscharfe (Harrell- und Uno-C-Index sowie zeitabhangige Flache unter der Receiver-Operating-Characteristic[ROC]-Kurve, AUC) und Vorhersagegenauigkeit (Bestimmtheitsmass [R2] und Likelihood-Quotienten-chi 2). Die Hazard Ratio (HR) wurde verwendet, um die Beziehung zwischen den Variablen des Modells und der Langzeitmortalitat aus samtlichen Ursachen zu ermitteln.ErgebnisseBei 197 Patienten (67 %) kam es zum Tod aus samtlichen Ursachen. Es bestand eine positive Assoziation zwischen dem PRECISE-DAPT-Score (die anderung von 17 auf 38 ging mit einer HR von 2,42 einher [95 %-Konfidenzintervall, 95 %-KI: 1,59-3,68], R2 = 0,209, zeitabhangige AUC = 0,69) und dem Risiko fur Tod, sodass in der adjustierten uberlebenskurve das Mortalitatsrisiko mit dem Anstieg des PRECISE-DAPT-Scores zunahm.SchlussfolgerungDer PRECISE-DAPT-Score stellt moglicherweise ein einfach zu verwendendes Instrument fur die Vorhersage der Langzeitmortalitat bei Patienten mit ACS und der Komplikation eines CS dar.en_US
dc.identifier.citation0
dc.identifier.doi10.1007/s00059-023-05231-0
dc.identifier.issn0340-9937
dc.identifier.issn1615-6692
dc.identifier.pmid38172314
dc.identifier.scopus2-s2.0-85181246153
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1007/s00059-023-05231-0
dc.identifier.urihttps://hdl.handle.net/20.500.14517/1109
dc.identifier.wosWOS:001135779300001
dc.identifier.wosqualityQ4
dc.institutionauthorAkyuz S.
dc.language.isoen
dc.publisherUrban & Vogelen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPRECISE-DAPT scoreen_US
dc.subjectAcute coronary syndromeen_US
dc.subjectCardiogenic shocken_US
dc.subjectMortalityen_US
dc.subjectPercutaneous coronary interventionen_US
dc.subjectPRECISE-DAPT-Scoreen_US
dc.subjectAkutes Koronarsyndromen_US
dc.subjectKardiogener Schocken_US
dc.subjectMortalitaten_US
dc.subjectPerkutane Koronarinterventionen_US
dc.titleThe predictive value of PRECISE-DAPT score for long-term mortality in patients with acute coronary syndrome complicated by cardiogenic shocken_US
dc.typeArticleen_US
dspace.entity.typePublication
relation.isAuthorOfPublicationbc63934a-59e5-4ebd-a4de-56adc33727ec
relation.isAuthorOfPublication.latestForDiscoverybc63934a-59e5-4ebd-a4de-56adc33727ec
relation.isOrgUnitOfPublication3650b163-f887-4449-965b-b97963ebdca5
relation.isOrgUnitOfPublication.latestForDiscovery3650b163-f887-4449-965b-b97963ebdca5

Files