In Vitro Evaluation of Adhesion of <i>Candida albicans</i> on CAD/CAM PMMA-Based Polymers

dc.authoridmurat, sema/0000-0003-0632-5095
dc.authoridCakmak, Gulce/0000-0003-1751-9207
dc.authorscopusid35339580500
dc.authorscopusid57193141901
dc.authorscopusid57203154737
dc.authorscopusid8888312400
dc.authorwosidmurat, sema/AAS-2104-2020
dc.authorwosiduzun, meltem/AAD-8135-2020
dc.contributor.authorMurat, Sema
dc.contributor.authorAlp, Gulce
dc.contributor.authorAlatali, Canan
dc.contributor.authorUzun, Meltem
dc.date.accessioned2024-05-25T11:41:04Z
dc.date.available2024-05-25T11:41:04Z
dc.date.issued2019
dc.departmentOkan Universityen_US
dc.department-temp[Murat, Sema] Ankara Univ, Dept Prosthodont, Fac Dent, Ankara, Turkey; [Alp, Gulce] Okan Univ, Dept Prosthodont, Fac Dent, Istanbul, Turkey; [Alatali, Canan; Uzun, Meltem] Istanbul Univ, Dept Med Microbiol, Fac Med, Istanbul, Turkeyen_US
dc.descriptionmurat, sema/0000-0003-0632-5095; Cakmak, Gulce/0000-0003-1751-9207en_US
dc.description.abstractPurpose To compare the amount of adherent Candida albicans to different CAD/CAM poly(methyl methacrylate) (PMMA)-based polymers and conventional heat-polymerized PMMA after long-term thermal cycling. Materials and Methods The specimens were subjected to 10,000 thermal cycles (5-55 degrees C) and divided into two groups, uncoated and pellicle-coated. Surface roughness and contact angles of the specimens were measured. The surface morphology was observed with scanning electron microscopy (SEM). An adhesion test was performed by incubating the disk specimens in C. albicans suspensions at 37 degrees C for 2 hours, and the adherent cells were counted under an optical microscope. The data were analyzed statistically using a variance analysis and Tukey HSD post hoc comparison test. The correlation between measurements was tested using a Pearson correlation analysis (alpha = 0.05). Results CAD/CAM polymers generally showed statistically significant lowest Ra and contact angle values, whereas conventional PMMA showed the highest Ra and contact angle values in the uncoated group (p < 0.05). Pellicle coating essentially increased contact angle of all materials and reduced the differences in a number of Candida cells on the materials (p < 0.05). Candida adhesion was statistically significantly greatest on conventional PMMA when compared to CAD/CAM polymers. A strong positive correlation was found between the surface roughness of the specimens (p < 0.05) and the amount of adhered cells, whereas no correlation was found between hydrophobicity of the specimens and the amount of adhered cells (p > 0.05). Conclusions CAD/CAM PMMA-based polymers may be preferable to reduce Candida-associated denture stomatitis in long-term use.en_US
dc.identifier.citationcount66
dc.identifier.doi10.1111/jopr.12942
dc.identifier.endpageE879en_US
dc.identifier.issn1059-941X
dc.identifier.issn1532-849X
dc.identifier.issue2en_US
dc.identifier.pmid29962017
dc.identifier.scopus2-s2.0-85050718778
dc.identifier.scopusqualityQ1
dc.identifier.startpageE873en_US
dc.identifier.urihttps://doi.org/10.1111/jopr.12942
dc.identifier.urihttps://hdl.handle.net/20.500.14517/1462
dc.identifier.volume28en_US
dc.identifier.wosWOS:000458904300082
dc.identifier.wosqualityQ1
dc.language.isoen
dc.publisherWileyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectC. albicansen_US
dc.subjectCAD/CAMen_US
dc.subjectdenture base materialsen_US
dc.subjectPMMAen_US
dc.subjectsurface propertiesen_US
dc.titleIn Vitro Evaluation of Adhesion of <i>Candida albicans</i> on CAD/CAM PMMA-Based Polymersen_US
dc.typeArticleen_US
dspace.entity.typePublication

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