Determination of Ophthalmic Drug Proparacaine Using Multi-walled Carbon Nanotube Paste Electrode by Square Wave Stripping Voltammetry

dc.authorid inam, onur/0000-0002-4726-1190
dc.authorid Demir, Ersin/0000-0001-9180-0609
dc.authorscopusid 55910480000
dc.authorscopusid 57200525596
dc.authorscopusid 6602858808
dc.authorwosid inam, onur/Q-3994-2017
dc.authorwosid Demir, Ersin/V-6633-2019
dc.contributor.author Demir, Ersin
dc.contributor.author Inam, Onur
dc.contributor.author Inam, Recai
dc.date.accessioned 2024-05-25T11:19:28Z
dc.date.available 2024-05-25T11:19:28Z
dc.date.issued 2018
dc.department Okan University en_US
dc.department-temp [Demir, Ersin] Okan Univ, Fac Engn, Dept Food Engn, TR-34959 Istanbul, Turkey; [Inam, Onur] Hacettepe Univ, Fac Med, Dept Ophthalmol, TR-06230 Ankara, Turkey; [Inam, Recai] Gazi Univ, Fac Sci, Dept Chem, TR-06500 Ankara, Turkey en_US
dc.description inam, onur/0000-0002-4726-1190; Demir, Ersin/0000-0001-9180-0609 en_US
dc.description.abstract Proparacaine, one of the most common local anesthetics to facilitate diagnosis and treatment of eye diseases, was assayed by square wave voltammetry using a paste electrode prepared with carbon nanotubes. In cyclic voltammetric studies, proparacaine has exhibited a single irreversible anodic peak at around + 900 mV vs. Ag/AgCl in pH 6.0 Britton-Robinson buffer solution. It was suggested that the peak had appeared due to the oxidation of the NH2 group on the proparacaine molecule. Prior to the determination of the proparacaine by square wave stripping voltammetry (SWSV) on the fabricated multi-walled carbon nanotube paste electrode (MWCNTPE), the accumulation potential (E-acc), accumulation time (r.c), pulse amplitude (Delta E), step potential (Delta E-s) and frequency (f) parameters were optimized. The peak currents plotted in the range of 0.5 - 12.5 mg/L proparacaine exhibited two linear sections with a detection limit of 0.11 mg/L. The results for the determination of proparacaine on a pharmaceutical local anesthetic (Alcaine) showed that relative standard deviation (RSD) and relative error (RE) were 4.1 and 2.0%, respectively. Selectivity has also been investigated and results showed recoveries of 5.0 mg/L proparacaine in the presence of 5.0 mg/L dopamine, ascorbic acid and uric acid as 106.9 +/- 0.8, 99.9 +/- 1.2 and 94.1 +/- 0.7, respectively. en_US
dc.identifier.citationcount 14
dc.identifier.doi 10.2116/analsci.17P589
dc.identifier.endpage 776 en_US
dc.identifier.issn 0910-6340
dc.identifier.issn 1348-2246
dc.identifier.issue 7 en_US
dc.identifier.pmid 29998957
dc.identifier.scopus 2-s2.0-85049638377
dc.identifier.scopusquality Q3
dc.identifier.startpage 771 en_US
dc.identifier.uri https://doi.org/10.2116/analsci.17P589
dc.identifier.uri https://hdl.handle.net/20.500.14517/421
dc.identifier.volume 34 en_US
dc.identifier.wos WOS:000440769400004
dc.identifier.wosquality Q4
dc.language.iso en
dc.publisher Japan Soc Analytical Chemistry en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 17
dc.subject Proparacaine en_US
dc.subject ophthalmic drug en_US
dc.subject voltammetry en_US
dc.subject carbon nanotube paste electrode en_US
dc.subject determination en_US
dc.title Determination of Ophthalmic Drug Proparacaine Using Multi-walled Carbon Nanotube Paste Electrode by Square Wave Stripping Voltammetry en_US
dc.type Article en_US
dc.wos.citedbyCount 16

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