The impact of acute and chronic aerobic and resistance exercise on stem cell mobilization: A review of effects in healthy and diseased individuals across different age groups

dc.authorscopusid57196302815
dc.authorscopusid59034949500
dc.authorscopusid22136195900
dc.authorscopusid57449950600
dc.authorscopusid23028598900
dc.contributor.authorLi, Wei
dc.contributor.authorSalahshour, Soheıl
dc.contributor.authorSajadi, S. Mohammad
dc.contributor.authorBaghaei, Sh.
dc.contributor.authorSalahshour, Soheil
dc.date.accessioned2024-05-25T12:18:32Z
dc.date.available2024-05-25T12:18:32Z
dc.date.issued2024
dc.departmentOkan Universityen_US
dc.department-temp[Li, Wei] Peoples Liberat Army Gen Hosp, Med Ctr 4, Dept Sports Med, Beijing 100048, Peoples R China; [Chen, Lingzhen] Zhejiang Gongshang Univ, Hangzhou Coll Commerce, Dept Sports & Arts, 66 South Huancheng Rd, Hangzhou, Peoples R China; [Sajadi, S. Mohammad] Cihan Univ Erbil, Dept Nutr, Erbil, Kurdistan, Iraq; [Baghaei, Sh.] Islamic Azad Univ, Khomeinishahr Branch, Dept Mech Engn, Tehran, Iran; [Salahshour, Soheil] Istanbul Okan Univ, Fac Engn & Nat Sci, Istanbul, Turkiye; [Salahshour, Soheil] Bahcesehir Univ, Fac Engn & Nat Sci, Istanbul, Turkiye; [Salahshour, Soheil] Lebanese Amer Univ, Dept Comp Sci & Math, Beirut, Lebanonen_US
dc.description.abstractStem cells (SCs) play a crucial role in tissue repair, regeneration, and maintaining physiological homeostasis. Exercise mobilizes and enhances the function of SCs. This review examines the effects of acute and chronic aerobic and resistance exercise on the population of SCs in healthy and diseased individuals across different age groups. Both acute intense exercise and moderate regular training increase circulating precursor cells CD34+ and, in particular, the subset of angiogenic progenitor cells (APCs) CD34+/ KDR+. Conversely, chronic exercise training has conflicting effects on circulating CD34+ cells and their function, which are likely influenced by exercise dosage, the health status of the participants, and the methodologies employed. While acute activity promotes transient mobilization, regular exercise often leads to an increased number of progenitors and more sustainable functionality. Short interventions lasting 10-21 days mobilize CD34+/KDR + APCs in sedentary elderly individuals, indicating the inherent capacity of the body to rapidly activate tissue-reparative SCs during activity. However, further investigation is needed to determine the optimal exercise regimens for enhancing SC mobilization, elucidating the underlying mechanisms, and establishing functional benefits for health and disease prevention. Current evidence supports the integration of intense exercise with chronic training in exercise protocols aimed at activating the inherent regenerative potential through SC mobilization. The physical activity promotes endogenous repair processes, and research on exercise protocols that effectively mobilize SCs can provide innovative guidelines designed for lifelong tissue regeneration. An artificial neural network (ANN) was developed to estimate the effects of modifying elderly individuals and implementing chronic resistance exercise on stem cell mobilization and its impact on individuals and exercise. The network's predictions were validated using linear regression and found to be acceptable compared to experimental results. (c) 2024, The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.description.woscitationindexScience Citation Index Expanded
dc.identifier.citation0
dc.identifier.doi10.1016/j.reth.2024.04.013
dc.identifier.endpage481en_US
dc.identifier.issn2352-3204
dc.identifier.pmid38745840
dc.identifier.scopus2-s2.0-85192136776
dc.identifier.scopusqualityQ2
dc.identifier.startpage464en_US
dc.identifier.urihttps://doi.org/10.1016/j.reth.2024.04.013
dc.identifier.volume27en_US
dc.identifier.wosWOS:001239679800001
dc.identifier.wosqualityQ2
dc.institutionauthorSalahshour S.
dc.language.isoen
dc.publisherElsevieren_US
dc.relation.ispartofRegenerative Therapyen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectExerciseen_US
dc.subjectStem cellsen_US
dc.subjectCellular mobilizationen_US
dc.subjectProgenitor cellsen_US
dc.subjectCD34+en_US
dc.subjectSport managementen_US
dc.titleThe impact of acute and chronic aerobic and resistance exercise on stem cell mobilization: A review of effects in healthy and diseased individuals across different age groupsen_US
dc.typeReviewen_US
dspace.entity.typePublication
relation.isAuthorOfPublicationf5ba517c-75fb-4260-af62-01c5f5912f3d
relation.isAuthorOfPublication.latestForDiscoveryf5ba517c-75fb-4260-af62-01c5f5912f3d

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