Digoxin is Not Related to Mortality in Patients with Heart Failure: Results from the SELFIE-TR Registry

dc.authorscopusid 57195943825
dc.authorscopusid 6602421975
dc.authorscopusid 58970080000
dc.authorscopusid 58970080100
dc.authorscopusid 58970691700
dc.authorscopusid 7202595585
dc.contributor.author Guvenc, Rengin cetin
dc.contributor.author Guvenc, Tolga Sinan
dc.contributor.author Caglar, Mert Efe
dc.contributor.author Al Arfaj, Abdullah Ayar
dc.contributor.author Behrad, Ailin
dc.contributor.author Yilmaz, Mehmet Birhan
dc.date.accessioned 2024-05-25T11:37:28Z
dc.date.available 2024-05-25T11:37:28Z
dc.date.issued 2024
dc.department Okan University en_US
dc.department-temp [Guvenc, Rengin cetin; Caglar, Mert Efe; Al Arfaj, Abdullah Ayar; Behrad, Ailin] Istanbul Okan Univ, Sch Med, Dept Internal Med Sci, Div Cardiol, Tepeoren Mahallesi Tuzla Kampusu, TR-34959 Istanbul, Turkiye; [Guvenc, Tolga Sinan] Istinye Univ, Dept Internal Med Sci, Div Cardiol, Sch Med, Istanbul, Turkiye; [Yilmaz, Mehmet Birhan] Dokuz Eylul Univ, Sch Med, Dept Internal Med Sci, Div Cardiol, Istanbul, Turkiye en_US
dc.description.abstract AimsDigoxin has been used in the treatment for heart failure for centuries, but the role of this drug in the modern era is controversial. A particular concern is the recent observational findings suggesting an increase in all-cause mortality with digoxin, although such observations suffer from biased results since these studies usually do not provide adequate compensation for the severity of disease. Using a nationwide registry database, we aimed to investigate whether digoxin is associated with 1-year all-cause mortality in patients with heart failure irrespective of phenotype.MethodsA total of 1014 out of 1054 patients in the registry, of whom 110 patients were on digoxin, were included in the study. Multivariable adjustments were done and propensity scores were calculated for various prognostic indicators, including signs and symptoms of heart failure and functional capacity. Crude mortality, mortality adjusted for covariates, mortality in the propensity score-matched cohort, and Bayesian factors (BFs) were analyzed.ResultsCrude 1-year mortality rate did not differ between patients on and off digoxin (17.3% vs 20.1%, log-rank p = 0.46), and digoxin was not related to mortality following multivariable adjustment (hazard ratio 0.87, 95% confidence interval 0.539-1.402, p = 0.57). Similarly, all-cause mortality was similar in 220 propensity-score adjusted patients (17.3% vs 20.0%, log-rank p = 0.55). On Bayesian analyses, there was moderate to strong evidence suggesting a lack of difference between in unmatched cohort (BF10 0.091) and weak-to-moderate evidence in the matched cohort (BF10 0.296).ConclusionsIn this nationwide cohort, we did not find any evidence for an increased 1-year mortality in heart failure patients on digoxin. en_US
dc.identifier.citationcount 0
dc.identifier.doi 10.1007/s40256-024-00639-3
dc.identifier.issn 1175-3277
dc.identifier.issn 1179-187X
dc.identifier.pmid 38573460
dc.identifier.scopus 2-s2.0-85189473321
dc.identifier.scopusquality Q1
dc.identifier.uri https://doi.org/10.1007/s40256-024-00639-3
dc.identifier.uri https://hdl.handle.net/20.500.14517/1173
dc.identifier.wos WOS:001197103000001
dc.identifier.wosquality Q3
dc.language.iso en
dc.publisher Adis int Ltd en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 1
dc.subject [No Keyword Available] en_US
dc.title Digoxin is Not Related to Mortality in Patients with Heart Failure: Results from the SELFIE-TR Registry en_US
dc.type Article en_US
dc.wos.citedbyCount 1

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