The effects of different doses of diclofenac sodium on newborn rat hippocampus exposed during the third trimester

dc.authoridAksoy, Abdurrahman/0000-0001-9486-312X
dc.authorscopusid56798472700
dc.authorscopusid7403238396
dc.authorscopusid56797959500
dc.authorscopusid16237906700
dc.authorscopusid15063935100
dc.authorwosidAksoy, Abdurrahman/N-3658-2014
dc.authorwosidKaplan, Suleyman/A-5396-2008
dc.contributor.authorElibol, Ebru
dc.contributor.authorKaplan, Suleyman
dc.contributor.authorAltun, Gamze
dc.contributor.authorAksoy, Abdurrahman
dc.contributor.authorAltunkaynak, Berrin Zuhal
dc.contributor.otherHistoloji ve Embriyoloji / Histology and Embriology
dc.date.accessioned2024-05-25T11:39:55Z
dc.date.available2024-05-25T11:39:55Z
dc.date.issued2020
dc.departmentOkan Universityen_US
dc.department-temp[Elibol, Ebru] Adiyaman Univ, Fac Med, Dept Histol & Embryol, Adiyaman, Turkey; [Kaplan, Suleyman; Altun, Gamze] Ondokuz Mayis Univ, Fac Med, Dept Histol & Embryol, Samsun, Turkey; [Aksoy, Abdurrahman] Ondokuz Mayis Univ, Fac Vet Med, Dept Pharmacol, Samsun, Turkey; [Altunkaynak, Berrin Zuhal] Istanbul Okan Univ, Fac Med, Dept Histol & Embryol, Istanbul, Turkeyen_US
dc.descriptionAksoy, Abdurrahman/0000-0001-9486-312X;en_US
dc.description.abstractThe main aim of the present study was to examine the neurotoxic effects of prenatal exposure to varying doses of diclofenac sodium (DS) on the rat hippocampus. Twenty-eight Wistar albino adult female rats weighing 280-300 g were initially used for pregnancy. When vaginal plaques were seen in female rats, it was accepted as the 0th day of pregnancy. Female rats were divided into five main groups; pure control, saline, low dose DS (3.6 mg/kg), moderate dose DS (9 mg/kg), and high dose DS (18 mg/kg). They were exposed to these treatments during their gestation. After birth, all newborn male rats were euthanized by overdose anesthesia on the 7th postnatal day. Histological and stereological techniques were used for analyzing tissue samples. The stereological analyses in this study showed that the number of neurons in the hippocampus may be reduced due to the use of DS. Histological investigation of the drug-treated groups showed significant cell loss compared to the control. Darkly stained nuclei of the neurons in the high dose group compared to the other groups were also obvious. When the results are evaluated, it can be concluded that the use of diclofenac sodium during pregnancy may have teratogenic effects on the development of the nervous system.en_US
dc.description.sponsorshipOndokuz Mayis University Project Management Office (Prof. Dr. Suleyman Kaplan) [PYO.TIP.1904.11.027]en_US
dc.description.sponsorshipThis work was supported by the Ondokuz Mayis University Project Management Office (Prof. Dr. Suleyman Kaplan; PYO.TIP.1904.11.027).en_US
dc.identifier.citation1
dc.identifier.doi10.3906/vet-1906-15
dc.identifier.endpage417en_US
dc.identifier.issn1300-0128
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85084219790
dc.identifier.scopusqualityQ3
dc.identifier.startpage404en_US
dc.identifier.trdizinid334754
dc.identifier.urihttps://doi.org/10.3906/vet-1906-15
dc.identifier.urihttps://hdl.handle.net/20.500.14517/1366
dc.identifier.volume44en_US
dc.identifier.wosWOS:000523562000032
dc.identifier.wosqualityQ4
dc.institutionauthorAltunkaynak, Berrin Zühal
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiclofenac sodiumen_US
dc.subjecthippocampusen_US
dc.subjectprenatalen_US
dc.subjectstereologyen_US
dc.subjectraten_US
dc.titleThe effects of different doses of diclofenac sodium on newborn rat hippocampus exposed during the third trimesteren_US
dc.typeArticleen_US
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery6322a75b-d2c9-4ab3-9e93-6d62d46b6331
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