The Association Between Monocyte/HDL-C Ratio and Heart Failure

Abstract

The monocyte/HDL-cholesterol ratio (MHR) was shown to be a marker of inflammation. This study investigated the utilization of this ratio as a measure of severity for heart failure which is a condition associated with inflammation. The MHR was calculated for 323 ambulatory patients with chronic heart failure and compared to other variables associated with the severity of the condition. Additionally, the impact of MHR on the Seattle Heart Failure Model (SHFM) score was investigated. MHR correlated positively with C-reactive protein (r: 0.312, p<0.001) and neutrophil-to-lymphocyte ratio (r: 0.242, p<0.001), but not with platelet-to-lymphocyte ratio. In addition, a correlation was found between the SHFM score and MHR (r:-0.267, p<0.001). The SHFM score exhibited a significant result for proB- type natriuretic peptide (pro-BNP) (p<0.001), neutrophil (p<0.001), hematocrit (p=0.001), and serum creatinine (p=0.001) in the ordinal logistic regression analysis, but not for MHR. MHR showed a negative correlation with left ventricular ejection fraction (r: -0.151, p: 0.007), exhibited a positive association with pro-BNP (r: 0.184, p<0.001), and no correlation with New York Heart Association classes. There is a significant correlation between the MHR value and the factors associated with the severity of heart failure. The prognosis and management of this condition may be assessed by utilizing the MHR value in conjunction with existing biomarkers.