Effect of renal function on the prognostic importance of chloride in patients with heart failure

dc.authorid ÇELİK, AHMET/0000-0002-9417-7610
dc.authorid Güvenç, Tolga Sinan/0000-0002-6738-266X
dc.authorid YILMAZ, Mehmet Birhan/0000-0002-8169-8628
dc.authorscopusid 57195943825
dc.authorscopusid 6602421975
dc.authorscopusid 55874244400
dc.authorscopusid 58151974800
dc.authorscopusid 57200233149
dc.authorscopusid 7202595585
dc.authorwosid ÇELİK, AHMET/AAA-6615-2021
dc.authorwosid Güvenç, Tolga Sinan/AAK-6020-2020
dc.authorwosid YILMAZ, Mehmet Birhan/Y-1372-2019
dc.contributor.author Guvenc, Rengin Cetin
dc.contributor.author Guevenc, Tolga Sinan
dc.contributor.author Temizhan, Ahmet
dc.contributor.author Cavusuglu, Yueksel
dc.contributor.author Celik, Ahmet
dc.contributor.author Yilmaz, Mehmet Birhan
dc.date.accessioned 2024-05-25T11:38:11Z
dc.date.available 2024-05-25T11:38:11Z
dc.date.issued 2023
dc.department Okan University en_US
dc.department-temp [Guvenc, Rengin Cetin] Istanbul Okan Univ, Sch Med, Dept Internal Med Sci, Div Cardiol, Istanbul, Turkiye; [Guevenc, Tolga Sinan] Istinye Univ, Sch Med, Dept Internal Med Sci, Div Cardiol, Istanbul, Turkiye; [Temizhan, Ahmet] Ankara City Hosp, Dept Cardiol, Ankara, Turkiye; [Cavusuglu, Yueksel] Eskisehir Osmangazi Univ, Sch Med, Dept Internal Med Sci, Div Cardiol, Istanbul, Turkiye; [Celik, Ahmet] Mersin Univ, Sch Med, Dept Internal Med Sci, Div Cardiol, Istanbul, Turkiye; [Yilmaz, Mehmet Birhan] Dokuz Eylul Univ, Sch Med, Dept Internal Med Sci, Div Cardiol, Istanbul, Turkiye en_US
dc.description ÇELİK, AHMET/0000-0002-9417-7610; Güvenç, Tolga Sinan/0000-0002-6738-266X; YILMAZ, Mehmet Birhan/0000-0002-8169-8628 en_US
dc.description.abstract Hypochloremia has recently gained interest as a potential marker of outcomes in patients with heart failure (HF). The exact pathophysiologic mechanism linking hypochloremia to HF is unclear but is thought to be mediated by chloride-sensitive proteins and channels located in kidneys. This analysis aimed to understand whether renal dysfunction (RD) affects the association of hypochloremia with mortality in patients with HF. Using data from a nationwide registry, 438 cases with complete data on serum chloride concentration and 1-year survival were included in the analysis. Patients with an estimated glomerular filtration rate of <60 mL/min/m(2) at baseline were accepted as having RD. Hypochloremia was defined as a chloride concentration <96 mEq/L at baseline. For HF patients without RD at baseline, patients with hypochloremia had a significantly higher 1-year all-cause mortality than those without hypochloremia (41.6% vs 13.0%, log-rank p < 0.001) and the association remained significant after multivariate adjustment (odds ratio (OR): 2.55, 95% confidence interval (CI): 1.25-5.21). The evidence supporting the association was very strong in this subgroup (Bayesian Factor (BF)(10): 48.25, log OR: 1.56, 95% CI: 0.69-2.43). For patients with RD at baseline, there was no statistically significant difference for 1-year mortality for patients with or without hypochloremia (36.3% vs 29.7, log-rank p = 0.35) and there was no evidence to support an association between hypochloremia and mortality (BF10: 1.18, log OR :0.66, 95% CI: -0.02 to 1.35). In patients with HF, the association between low chloride concentration and mortality is limited to those without RD at baseline. en_US
dc.identifier.citationcount 0
dc.identifier.doi 10.1177/10815589221149186
dc.identifier.endpage 349 en_US
dc.identifier.issn 1081-5589
dc.identifier.issn 1708-8267
dc.identifier.issue 4 en_US
dc.identifier.pmid 36680353
dc.identifier.scopus 2-s2.0-85150665900
dc.identifier.scopusquality Q2
dc.identifier.startpage 339 en_US
dc.identifier.uri https://doi.org/10.1177/10815589221149186
dc.identifier.uri https://hdl.handle.net/20.500.14517/1251
dc.identifier.volume 71 en_US
dc.identifier.wos WOS:000956447300004
dc.identifier.wosquality Q3
dc.language.iso en
dc.publisher Sage Publications Ltd en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 0
dc.subject Heart failure en_US
dc.subject mortality en_US
dc.subject renal dysfunction en_US
dc.subject hypochloremia en_US
dc.title Effect of renal function on the prognostic importance of chloride in patients with heart failure en_US
dc.type Article en_US
dc.wos.citedbyCount 0

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