Application of 3D, 4D, 5D, and 6D bioprinting in cancer research: what does the future look like?

dc.authorid Iravani, Siavash/0000-0003-3985-7928
dc.authorid Zarrabi, Ali/0000-0003-0391-1769
dc.authorscopusid 57204962106
dc.authorscopusid 59009439300
dc.authorscopusid 57305831500
dc.authorscopusid 57221728496
dc.authorscopusid 57202500098
dc.authorscopusid 56700291100
dc.authorscopusid 35336983500
dc.authorwosid Iravani, Siavash/F-4046-2014
dc.authorwosid Zarrabi, Ali/U-2602-2019
dc.contributor.author Khorsandi, Danial
dc.contributor.author Rezayat, Dorsa
dc.contributor.author Sezen, Serap
dc.contributor.author Ferrao, Rafaela
dc.contributor.author Khosravi, Arezoo
dc.contributor.author Zarepour, Atefeh
dc.contributor.author Zarrabi, Ali
dc.date.accessioned 2024-05-25T11:37:30Z
dc.date.available 2024-05-25T11:37:30Z
dc.date.issued 2024
dc.department Okan University en_US
dc.department-temp [Khorsandi, Danial; Ferrao, Rafaela] Terasaki Inst Biomed Innovat, Los Angeles, CA 90024 USA; [Rezayat, Dorsa] Univ Cincinnati, Coll Engn & Appl Sci, Ctr Global Design & Mfg, 2901 Woodside Dr, Cincinnati, OH 45221 USA; [Sezen, Serap] Sabanci Univ, Fac Engn & Nat Sci, TR-34956 Istanbul, Turkiye; [Sezen, Serap] Sabanci Univ, Nanotechnol Res & Applicat Ctr, TR-34956 Istanbul, Turkiye; [Ferrao, Rafaela] Univ Coimbra, Inst Interdisciplinary Res, Doctoral Programme Expt Biol & Biomed PDBEB, Coimbra, Portugal; [Khosravi, Arezoo] Istanbul Okan Univ, Fac Engn & Nat Sci, Dept Genet & Bioengn, TR-34959 Istanbul, Turkiye; [Zarepour, Atefeh] Saveetha Univ, Saveetha Dent Coll & Hosp, Saveetha Inst Med & Tech Sci, Dept Res Analyt, Chennai 600077, India; [Khorsandi, Melika; Hashemian, Mohammad] Islamic Azad Univ, Dept Cellular & Mol Biol, Najafabad Branch, Esfahan, Iran; [Iravani, Siavash] W Nazar ST, Boostan Ave, Esfahan, Iran; [Zarrabi, Ali] Istinye Univ, Fac Engn & Nat Sci, Dept Biomed Engn, TR-34396 Istanbul, Turkiye; [Zarrabi, Ali] Yuan Ze Univ, Grad Sch Biotechnol & Bioengn, Taoyuan 320315, Taiwan en_US
dc.description Iravani, Siavash/0000-0003-3985-7928; Zarrabi, Ali/0000-0003-0391-1769 en_US
dc.description.abstract The application of three- and four-dimensional (3D/4D) printing in cancer research represents a significant advancement in understanding and addressing the complexities of cancer biology. 3D/4D materials provide more physiologically relevant environments compared to traditional two-dimensional models, allowing for a more accurate representation of the tumor microenvironment that enables researchers to study tumor progression, drug responses, and interactions with surrounding tissues under conditions similar to in vivo conditions. The dynamic nature of 4D materials introduces the element of time, allowing for the observation of temporal changes in cancer behavior and response to therapeutic interventions. The use of 3D/4D printing in cancer research holds great promise for advancing our understanding of the disease and improving the translation of preclinical findings to clinical applications. Accordingly, this review aims to briefly discuss 3D and 4D printing and their advantages and limitations in the field of cancer. Moreover, new techniques such as 5D/6D printing and artificial intelligence (AI) are also introduced as methods that could be used to overcome the limitations of 3D/4D printing and opened promising ways for the fast and precise diagnosis and treatment of cancer. Recent advancements pertaining to the application of 3D, 4D, 5D, and 6D bioprinting in cancer research are discussed, focusing on important challenges and future perspectives. en_US
dc.identifier.citationcount 0
dc.identifier.doi 10.1039/d4tb00310a
dc.identifier.issn 2050-750X
dc.identifier.issn 2050-7518
dc.identifier.pmid 38686396
dc.identifier.scopus 2-s2.0-85191811462
dc.identifier.scopusquality Q1
dc.identifier.uri https://doi.org/10.1039/d4tb00310a
dc.identifier.uri https://hdl.handle.net/20.500.14517/1179
dc.identifier.wos WOS:001209568400001
dc.identifier.wosquality Q1
dc.institutionauthor Khosravi A.
dc.language.iso en
dc.publisher Royal Soc Chemistry en_US
dc.relation.publicationcategory Diğer en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 4
dc.subject [No Keyword Available] en_US
dc.title Application of 3D, 4D, 5D, and 6D bioprinting in cancer research: what does the future look like? en_US
dc.type Review en_US
dc.wos.citedbyCount 2

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