Tuberculosis vaccine developments and efficient delivery systems: A comprehensive appraisal

dc.authorscopusid 58894965300
dc.authorscopusid 16303715400
dc.authorscopusid 11640687900
dc.authorscopusid 26028762100
dc.authorscopusid 26029577800
dc.authorscopusid 45461160600
dc.authorscopusid 57203141747
dc.contributor.author Hoseinpour, Rasoul
dc.contributor.author Hasani, Alka
dc.contributor.author Baradaran, Behzad
dc.contributor.author Abdolalizadeh, Jalal
dc.contributor.author Salehi, Roya
dc.contributor.author Hasani, Akbar
dc.contributor.author Memar, Mohammad Yousef
dc.date.accessioned 2024-05-25T11:37:38Z
dc.date.available 2024-05-25T11:37:38Z
dc.date.issued 2024
dc.department Okan University en_US
dc.department-temp [Hoseinpour, Rasoul; Nabizadeh, Edris; Memar, Mohammad Yousef] Tabriz Univ Med Sci, Infect & Trop Dis Res Ctr, Tabriz, Iran; [Hoseinpour, Rasoul; Hasani, Alka; Baradaran, Behzad; Nabizadeh, Edris] Tabriz Univ Med Sci, Immunol Res Ctr IRC, Tabriz, Iran; [Hoseinpour, Rasoul] Islamic Azad Univ, Fac Med, Dept Lab Sci & Microbiol, Tabriz Med Sci, Tabriz, Iran; [Hasani, Alka] Tabriz Univ Med Sci, Fac Med, Dept Med Microbiol, Tabriz, Iran; [Hasani, Alka; Kafil, Hossein Samadi] Tabriz Univ Med Sci, Fac Med, Sina Educ Res & Treatment Ctr, Clin Res Dev Unit, Tabriz, Iran; [Abdolalizadeh, Jalal; Salehi, Roya; Kafil, Hossein Samadi] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran; [Abdolalizadeh, Jalal; Salehi, Roya; Kafil, Hossein Samadi] Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Med Nanotechnol, Tabriz, Iran; [Hasani, Akbar] Tabriz Univ Med Sci, Dept Clin Biochem & Appl Sci, Tabriz, Iran; [Yekani, Mina] Kashan Univ Med Sci, Fac Med, Dept Microbiol, Kashan, Iran; [Yekani, Mina] Kashan Univ Med Sci, Student Res Comm, Kashan, Iran; [Hasani, Roqaiyeh] Istanbul Okan Univ, TR-34959 Tuzla Istanbu, Turkiye; [Azizian, Khalil] Kurdistan Univ Med Sci, Fac Med, Dept Microbiol, Sanandaj, Iran; [Hasani, Alka] Tabriz Univ Med Sci, Immunol Res Ctr IRC, Dept Med Microbiol, Tabriz, Iran; [Hasani, Alka] Tabriz Univ Med Sci, Fac Med, Sina Educ Res & Treatment Ctr, Clin Res Dev Unit, Tabriz, Iran en_US
dc.description.abstract Despite the widespread use of the Bacillus Calmette-Gue ' rin (BCG) vaccine, Mycobacterium tuberculosis (MTB) continues to be a global burden. Vaccination has been proposed to prevent and treat tuberculosis (TB) infection, and several of them are in different phases of clinical trials. Though vaccine production is in progress but requires more attention. There are several TB vaccines in the trial phase, most of which are based on a combination of proteins/adjuvants or recombinant viral vectors used for selected MTB antigens. In this review, we attempted to discuss different types of TB vaccines based on the vaccine composition, the immune responses generated, and their clinical trial phases. Furthermore, we have briefly overviewed the effective delivery systems used for the TB vaccine and their effectiveness in different vaccines. en_US
dc.description.sponsorship Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran en_US
dc.description.sponsorship This study was supported by the Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran. en_US
dc.identifier.citationcount 0
dc.identifier.doi 10.1016/j.heliyon.2024.e26193
dc.identifier.issn 2405-8440
dc.identifier.issue 4 en_US
dc.identifier.pmid 38404880
dc.identifier.scopus 2-s2.0-85185467092
dc.identifier.scopusquality Q1
dc.identifier.uri https://doi.org/10.1016/j.heliyon.2024.e26193
dc.identifier.uri https://hdl.handle.net/20.500.14517/1200
dc.identifier.volume 10 en_US
dc.identifier.wos WOS:001200041100001
dc.identifier.wosquality Q2
dc.language.iso en
dc.publisher Cell Press en_US
dc.relation.publicationcategory Diğer en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 2
dc.subject Tuberculosis en_US
dc.subject Vaccine en_US
dc.subject Delivery systems en_US
dc.subject BacillusCalmette-Guerin en_US
dc.title Tuberculosis vaccine developments and efficient delivery systems: A comprehensive appraisal en_US
dc.type Review en_US
dc.wos.citedbyCount 2

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