Modulation of Melatonin Receptors Regulates Reproductive Physiology: The Impact of Agomelatine on the Estrus Cycle, Gestation, Offspring, and Uterine Contractions in Rats

dc.authorscopusid 54681943600
dc.authorscopusid 58348271000
dc.authorscopusid 57214054591
dc.authorscopusid 58072738800
dc.authorscopusid 18038758400
dc.authorscopusid 12808111600
dc.authorscopusid 56985668900
dc.authorwosid Serhatlioglu, Ihsan/V-9821-2018
dc.contributor.author Kacar, Emine
dc.contributor.author Tan, Fatih
dc.contributor.author Sahinturk, Serdar
dc.contributor.author Zorlu, Gokhan
dc.contributor.author Serhatlioglu, Ihsan
dc.contributor.author Bulmus, Ozgur
dc.contributor.author Kelestimur, Haluk
dc.contributor.other Fizyoloji / Physiology
dc.date.accessioned 2024-05-25T11:37:50Z
dc.date.available 2024-05-25T11:37:50Z
dc.date.issued 2023
dc.department Okan University en_US
dc.department-temp [Kacar, Emine; Tan, Fatih] Firat Univ, Fac Med, Physiol Dept, Elazig, Turkiye; [Sahinturk, Serdar] Bursa Uludağ Univ, Fac Med, Physiol Dept, Bursa, Turkiye; [Zorlu, Gokhan; Serhatlioglu, Ihsan] Firat Univ, Fac Med, Biophys Dept, Elazig, Turkiye; [Bulmus, Ozgur] Balıkesir Univ, Fac Med, Physiol Dept, Balikesir, Turkiye; [Ercan, Zubeyde] Firat Univ, Fac Hlth Sci, Dept Phys Therapy & Rehabil, Elazig, Turkiye; [Kelestimur, Haluk] Istanbul Okan Univ, Fac Med, Physiol Dept, Istanbul, Turkiye en_US
dc.description.abstract Agomelatine is a pharmaceutical compound that functions as an agonist for melatonin receptors, with a particular affinity for the MT1 and MT2 receptor subtypes. Its mode of action is integral to the regulation of diverse physiological processes, encompassing the orchestration of circadian rhythms, sleep-wake cycles, and mood modulation. In the present study, we delve into the intricate interplay between agomelatine and the modulation of estrus cycles, gestation periods, offspring numbers, and uterine contractions, shedding light on their collective impact on reproductive physiology. Both in vivo and in vitro experiments were performed. Wistar Albino rats, divided into four groups: two non-pregnant groups (D1 and D2) and two pregnant groups (G1 and G2). The D1 and G1 groups served as control groups, while the D2 and G2 groups received chronic agomelatine administration (10 mg/kg). Uterine contractions were assessed in vitro using myometrial strips. Luzindole, a melatonin receptor antagonist, was employed to investigate the pathway mediating agomelatine's effects on uterine contractions. In in vivo studies, chronic agomelatine administration extended the diestrus phase (p<0.05) in non-pregnant rats, prolonged the gestational period (p<0.01), and increased the fetal count (p<0.01) in pregnant rats. Additionally, agomelatine reduced plasma oxytocin and prostoglandin-E levels (p<0.01) during pregnancy. In vitro experiments showed that agomelatine dose-dependently inhibited spontaneous and oxytocin-induced myometrial contractions. Luzindole (2 mu M) reverse the agomelatine-induced inhibition of myometrial contractions. These findings suggest that agomelatine holds the potential to modulate diverse reproductive parameters during the gestational period, influencing estrus cycling, gestational progression, offspring development, and the orchestration of uterine contractions. en_US
dc.description.sponsorship FUBAP (Scientific Research Projects Automation) [TF.17.39] en_US
dc.description.sponsorship This work was supported by FUBAP ((Scientific Research Projects Automation)/TF.17.39). en_US
dc.identifier.citationcount 0
dc.identifier.doi 10.33549/physiolres.935064
dc.identifier.endpage 807 en_US
dc.identifier.issn 0862-8408
dc.identifier.issn 1802-9973
dc.identifier.issue 6 en_US
dc.identifier.pmid 38215065
dc.identifier.scopus 2-s2.0-85182305191
dc.identifier.scopusquality Q3
dc.identifier.startpage 793 en_US
dc.identifier.uri https://doi.org/10.33549/physiolres.935064
dc.identifier.uri https://hdl.handle.net/20.500.14517/1224
dc.identifier.volume 72 en_US
dc.identifier.wos WOS:001136613100006
dc.identifier.wosquality Q3
dc.institutionauthor KELESTIMUR H.
dc.language.iso en
dc.publisher Acad Sciences Czech Republic, inst Physiology en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 3
dc.subject Agomelatine en_US
dc.subject Myometrial contractions en_US
dc.subject Gestational age en_US
dc.subject Number of offspring en_US
dc.subject Rat pregnancy en_US
dc.title Modulation of Melatonin Receptors Regulates Reproductive Physiology: The Impact of Agomelatine on the Estrus Cycle, Gestation, Offspring, and Uterine Contractions in Rats en_US
dc.type Article en_US
dc.wos.citedbyCount 3

Files