Histopathological and biochemical evaluation of paeoniflorin administration in an experimental periodontitis model

dc.authorid CIFTCI, ALPER/0000-0001-8370-8677
dc.authorid KURT BAYRAKDAR, Sevda/0000-0002-3711-6520
dc.authorscopusid 57208276020
dc.authorscopusid 55663819500
dc.authorscopusid 57202306502
dc.authorscopusid 34980023500
dc.authorscopusid 8343091600
dc.authorscopusid 56463728100
dc.authorscopusid 56463728100
dc.authorwosid kurt bayrakdar, sevda/AFV-9029-2022
dc.authorwosid CIFTCI, ALPER/AAD-9374-2022
dc.contributor.author Gurkan, Cagla Gul
dc.contributor.author Keles, Gonca Cayir
dc.contributor.author Kurt, Sevda
dc.contributor.author Ciftci, Alper
dc.contributor.author Ayas, Bulent
dc.contributor.author Guler, Sevki
dc.contributor.author Cetinkaya, Burcu Ozkan
dc.date.accessioned 2024-05-25T11:40:01Z
dc.date.available 2024-05-25T11:40:01Z
dc.date.issued 2019
dc.department Okan University en_US
dc.department-temp [Gurkan, Cagla Gul] Bafra Publ Oral Hlth Ctr, Samsun, Turkey; [Keles, Gonca Cayir] Istanbul Okan Univ, Fac Dent, Dept Periodontol, Istanbul, Turkey; [Kurt, Sevda] Recep Tayyip Erdogan Univ, Fac Dent, Dept Periodontol, TR-53100 Rize, Turkey; [Ciftci, Alper] Ondokuz Mayis Univ, Fac Vet Med, Dept Microbiol, Samsun, Turkey; [Ayas, Bulent] Ondokuz Mayis Univ, Fac Med, Dept Histol & Embriol, Samsun, Turkey; [Guler, Sevki] Abant Izzet Baysal Univ, Fac Dent, Dept Periodontol, Bolu, Turkey; [Cetinkaya, Burcu Ozkan] Ondokuz Mayis Univ, Fac Dent, Dept Periodontol, Samsun, Turkey en_US
dc.description CIFTCI, ALPER/0000-0001-8370-8677; KURT BAYRAKDAR, Sevda/0000-0002-3711-6520 en_US
dc.description.abstract The purpose of this study was to evaluate the effects of administered Paeoniflorin (Pae) on periodontal tissues within an experimental periodontitis model. Forty male Wistar rats were used in this study and experimental periodontitis was created in all rats except in the control group (n = 10, first group). In the periodontitis group, experimental periodontitis was created but no other application was performed (n = 10, second group). In the other groups created experimental periodontitis, systemic Pae (n = 10, third group) or saline (n = 10, fourth group) was applied. A biochemical analysis of the gingival vascular endothelial growth factor (VEGF) levels and a histomorphometric analysis (measurements of the area of alveolar bone, alveolar bone resorption, and attachment loss) were performed. In the Pae group, the area of the alveolar bone was increased, while alveolar bone resorption and attachment loss decreased. Gingival VEGF levels increased in all groups that created experimental periodontitis and the greatest increase seen in the Pae group. Histomorphometric and biochemical analyses in this study suggest that Pae has a curative effect on periodontal tissues. However, additional studies are needed to confirm these results. en_US
dc.description.sponsorship Scientific Research Fund of Ondokuz Mayis University in Samsun/Turkey [PYO.DIS.1904.15.001] en_US
dc.description.sponsorship This study was supported by the Scientific Research Fund of Ondokuz Mayis University in Samsun/Turkey (Project number: PYO.DIS.1904.15.001). en_US
dc.identifier.citationcount 1
dc.identifier.doi 10.2334/josnusd.18-0427
dc.identifier.endpage 557 en_US
dc.identifier.issn 1343-4934
dc.identifier.issn 1880-4926
dc.identifier.issue 4 en_US
dc.identifier.pmid 31588098
dc.identifier.scopus 2-s2.0-85075700103
dc.identifier.scopusquality Q2
dc.identifier.startpage 554 en_US
dc.identifier.uri https://doi.org/10.2334/josnusd.18-0427
dc.identifier.uri https://hdl.handle.net/20.500.14517/1392
dc.identifier.volume 61 en_US
dc.identifier.wos WOS:000509391800015
dc.identifier.wosquality Q4
dc.language.iso en
dc.publisher Nihon Univ, School dentistry en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 1
dc.subject experimental periodontitis en_US
dc.subject histology en_US
dc.subject herbal medicine en_US
dc.title Histopathological and biochemical evaluation of paeoniflorin administration in an experimental periodontitis model en_US
dc.type Article en_US
dc.wos.citedbyCount 1

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