Investigation of the neuroprotective effects of thymoquinone on rat spinal cord exposed to 900 MHz electromagnetic field

dc.authorid Yahyazadeh, Ahmad/0000-0002-6093-3588
dc.authorscopusid 56521486700
dc.authorscopusid 15063935100
dc.authorwosid Yahyazadeh, Ahmad/AED-6755-2022
dc.contributor.author Yahyazadeh, Ahmad
dc.contributor.author Altunkaynak, Berrin Zuhal
dc.date.accessioned 2024-05-25T11:39:58Z
dc.date.available 2024-05-25T11:39:58Z
dc.date.issued 2019
dc.department Okan University en_US
dc.department-temp [Yahyazadeh, Ahmad] Karabuk Univ, Fac Med, Dept Histol & Embryol, Karabuk, Turkey; [Altunkaynak, Berrin Zuhal] Okan Univ, Fac Med, Dept Histol & Embryol, Istanbul, Turkey en_US
dc.description Yahyazadeh, Ahmad/0000-0002-6093-3588 en_US
dc.description.abstract Exposure to electromagnetic field in long-term use of cell phones has increased concerns about serious health problems. Our aim was to survey the possible effects of electromagnetic field radiation (60 min/day for 28 days) on the spinal cords of 12 weeks old rats. Further, we investigated whether the administration of thymoquinone (10 mg/kg/day) would protect the spinal cord tissue against the adverse effects of electromagnetic field or not. Twenty-four adult male Wistar albino rats were assigned randomly into four groups: control, electromagnetic field, thymoquinone and electromagnetic field + thymoquinone. The cervical spinal cords of all rats was evaluated using the stereological, biochemical and histological methods. The number of motor neurons were reduced in the electromagnetic field group compared to the control group (p < 0.05). Superoxide dismutase level was higher in the electromagnetic field group compared to the control group (p < 0.05). In the electromagnetic field + thymoquinone group, we found an increase in the number of motor neurons and decrease in superoxide dismutase activity compared to the electromagnetic field group (p < 0.05). Our histological findings also exhibit the remarkable architectural alterations. We speculated that electromagnetic field radiation induced the morphological and biochemical damage to the spinal cord tissue of rats. Administration of antioxidant, thymoquinone, also ameliorated such complications caused by electromagnetic field. en_US
dc.description.sponsorship Ondokuz Mayis University project management office [1904.14.018] en_US
dc.description.sponsorship This work was supported by Ondokuz Mayis University project management office [1904.14.018]. en_US
dc.identifier.citationcount 13
dc.identifier.doi 10.1016/j.jchemneu.2019.101657
dc.identifier.issn 0891-0618
dc.identifier.issn 1873-6300
dc.identifier.pmid 31228532
dc.identifier.scopus 2-s2.0-85067596052
dc.identifier.scopusquality Q3
dc.identifier.uri https://doi.org/10.1016/j.jchemneu.2019.101657
dc.identifier.uri https://hdl.handle.net/20.500.14517/1380
dc.identifier.volume 100 en_US
dc.identifier.wos WOS:000486357600009
dc.identifier.wosquality Q3
dc.language.iso en
dc.publisher Elsevier en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 15
dc.subject Thymoquinone en_US
dc.subject Electromagnetic field en_US
dc.subject Stereology en_US
dc.subject Spinal cord en_US
dc.subject Superoxide dismutase en_US
dc.subject Rat en_US
dc.title Investigation of the neuroprotective effects of thymoquinone on rat spinal cord exposed to 900 MHz electromagnetic field en_US
dc.type Article en_US
dc.wos.citedbyCount 13

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