A stereological study of the effects of antidepressants on postmenopausal rat kidney
| dc.authorid | kurtoglu, emel/0000-0002-2183-7227 | |
| dc.authorid | ozdes, emel kurtoglu/0000-0002-2183-7227 | |
| dc.authorscopusid | 55133866200 | |
| dc.authorscopusid | 15063935100 | |
| dc.authorscopusid | 26425788700 | |
| dc.authorscopusid | 24773142500 | |
| dc.authorscopusid | 55623179000 | |
| dc.authorscopusid | 6701466395 | |
| dc.authorwosid | kurtoglu, emel/AAC-3010-2020 | |
| dc.authorwosid | ozdes, emel kurtoglu/AAQ-9916-2020 | |
| dc.contributor.author | Ozdes, E. | |
| dc.contributor.author | Altunkaynak, B. Z. | |
| dc.contributor.author | Deniz, O. G. | |
| dc.contributor.author | Ilkaya, F. | |
| dc.contributor.author | Guzel, H. | |
| dc.contributor.author | Kokcu, A. | |
| dc.date.accessioned | 2024-05-25T11:39:58Z | |
| dc.date.available | 2024-05-25T11:39:58Z | |
| dc.date.issued | 2020 | |
| dc.department | Okan University | en_US |
| dc.department-temp | [Ozdes, E.] Mem Hizmet Hosp, Dept Gynaecol & Obstet, Istanbul, Turkey; [Altunkaynak, B. Z.] Istanbul Okan Univ, Med Fac, Dept Histol & Embryol, Istanbul, Turkey; [Deniz, O. G.] Ondokuz Mayis Univ, Med Fac, Dept Histol & Embryol, Samsun, Turkey; [Ilkaya, F.; Guzel, H.] Ondokuz Mayis Univ, Med Fac, Dept Pharmacol, Samsun, Turkey; [Kokcu, A.] Med Pk Hosp, Dept Gynaecol & Obstet, Samsun, Turkey | en_US |
| dc.description | kurtoglu, emel/0000-0002-2183-7227; ozdes, emel kurtoglu/0000-0002-2183-7227 | en_US |
| dc.description.abstract | Many factors can cause depression including genes (DNA), brain chemistry or stress. Antidepressant drugs affect the brain, heart, liver and kidney. We investigated the effects of the antidepressant drugs, amitriptyline (AMI) and paroxetine (PARO) on kidney. We used 24 adult female rats that were ovariectomized bilaterally 7 days before the experiment. The ovariectomized (OVX) animals and healthy control rats were divided into four equal groups for 4 weeks: control group, OVX control group (sham), AMI group and PARO group. Following the experimental period, the Cavalieri method was applied to sections of the kidney. PARO produced adverse effects on distal and proximal tubule volume, but AMI had no effect on the volume of distal and proximal tubules. Both PARO and AMI decreased the volume of Bowman spaces. PARO also damaged the kidney tubules and cells. | en_US |
| dc.identifier.citationcount | 2 | |
| dc.identifier.doi | 10.1080/10520295.2019.1680865 | |
| dc.identifier.endpage | 267 | en_US |
| dc.identifier.issn | 1052-0295 | |
| dc.identifier.issn | 1473-7760 | |
| dc.identifier.issue | 4 | en_US |
| dc.identifier.pmid | 31746664 | |
| dc.identifier.scopus | 2-s2.0-85084326928 | |
| dc.identifier.scopusquality | Q3 | |
| dc.identifier.startpage | 262 | en_US |
| dc.identifier.uri | https://doi.org/10.1080/10520295.2019.1680865 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14517/1381 | |
| dc.identifier.volume | 95 | en_US |
| dc.identifier.wos | WOS:000498357400001 | |
| dc.identifier.wosquality | Q4 | |
| dc.language.iso | en | |
| dc.publisher | Taylor & Francis Ltd | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.scopus.citedbyCount | 2 | |
| dc.subject | amitriptyline | en_US |
| dc.subject | antidepressants | en_US |
| dc.subject | kidney | en_US |
| dc.subject | paroxetine | en_US |
| dc.subject | serotonin re-uptake inhibitors | en_US |
| dc.subject | stereology | en_US |
| dc.subject | tricyclics | en_US |
| dc.title | A stereological study of the effects of antidepressants on postmenopausal rat kidney | en_US |
| dc.type | Article | en_US |
| dc.wos.citedbyCount | 2 |