Clinicopathologic and Prognostic Features in Gallbladder Malignancies: Retrospective Analysis of 5206 Cases

dc.authorid Kartal, Abdulcabbar/0000-0001-7536-3146
dc.authorid ferhatoglu, m ferhat/0000-0003-1520-7517
dc.authorid KIVILCIM, Taner/0000-0003-0088-1189
dc.authorid Senol, Kazim/0000-0001-6273-0664
dc.authorscopusid 57205505728
dc.authorscopusid 55632701500
dc.authorscopusid 55177017500
dc.authorscopusid 35798520900
dc.authorscopusid 7004369943
dc.authorwosid Senol, Kazim/JAC-4052-2023
dc.authorwosid Senol, Kazim/AAE-4809-2019
dc.authorwosid Kartal, Abdulcabbar/Y-3416-2019
dc.authorwosid ferhatoglu, m ferhat/AAB-3270-2019
dc.contributor.author Ferhatoglu, Murat Ferhat
dc.contributor.author Senol, Kazim
dc.contributor.author Kivilcim, Taner
dc.contributor.author Kartal, Abdulcabbar
dc.contributor.author Gurkan, Alp
dc.date.accessioned 2024-05-25T11:41:36Z
dc.date.available 2024-05-25T11:41:36Z
dc.date.issued 2019
dc.department Okan University en_US
dc.department-temp [Ferhatoglu, Murat Ferhat; Kivilcim, Taner; Kartal, Abdulcabbar; Gurkan, Alp] Okan Univ, Fac Med, Dept Gen Surg, Istanbul, Turkey; [Senol, Kazim] Koc Univ, Fac Med, Dept Gen Surg, Istanbul, Turkey en_US
dc.description Kartal, Abdulcabbar/0000-0001-7536-3146; ferhatoglu, m ferhat/0000-0003-1520-7517; KIVILCIM, Taner/0000-0003-0088-1189; Senol, Kazim/0000-0001-6273-0664 en_US
dc.description.abstract Aim: Gallbladder cancer is the sixth most common cancer of the gastrointestinal system. Clinical presentation may not be distinguished from cholelithiasis or cholecystitis and most patients are diagnosed intraoperatively or in the postoperative histologic examination. In this study, we aimed to investigate the association of incidentally detected gallbladder cancer with gallbladder premalignant lesions, age, gender, ultrasonography features and gallbladder stones. Methods: Demographic and clinical characteristics and pathology results of 5206 patients who underwent cholecystectomy between January 2012 and December 2015 were evaluated retrospectively. Results: Three thousand eight hundred and eighty four (74.6%) patients were female. Pathologic reports showed pre-malignant and malignant lesions in 102 (1.95%) cases. Metaplasia was significantly more common in females, while no significant difference was found in development of dysplasia and cancer between genders. Gallbladder stone was found to be a risk factor for the development of metaplasia. Gallbladder wall thickening and advanced age are the most important risk factors for gallbladder cancer. Conclusion: Female gender and gallstone are important risk factors for the development of metaplasia. Advanced age, gallstone and gallbladder wall thickening on ultrasonography are the most important factors in the development cancer. Cholecystectomy should be kept in mind as the most effective method to prevent cancer development in elderly patients with gallbladder stones. en_US
dc.identifier.citationcount 1
dc.identifier.doi 10.4274/haseki.galenos.2018.4500
dc.identifier.endpage 152 en_US
dc.identifier.issn 1302-0072
dc.identifier.issn 2147-2688
dc.identifier.issue 2 en_US
dc.identifier.scopus 2-s2.0-85064355817
dc.identifier.scopusquality Q3
dc.identifier.startpage 147 en_US
dc.identifier.trdizinid 311956
dc.identifier.uri https://doi.org/10.4274/haseki.galenos.2018.4500
dc.identifier.uri https://hdl.handle.net/20.500.14517/1538
dc.identifier.volume 57 en_US
dc.identifier.wos WOS:000462506200007
dc.institutionauthor Gürkan A.
dc.language.iso en
dc.publisher Galenos Yayincilik en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 1
dc.subject Gallbladder carcinoma en_US
dc.subject gallstone en_US
dc.subject malignancy en_US
dc.title Clinicopathologic and Prognostic Features in Gallbladder Malignancies: Retrospective Analysis of 5206 Cases en_US
dc.type Article en_US
dc.wos.citedbyCount 1

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