Autophagy as a molecular target for cancer treatment

dc.authorid kig, cenk/0000-0002-6318-5001
dc.authorid Kocaturk, Nur/0000-0002-4452-9913
dc.authorid Akkoc, Yunus/0000-0001-5379-6151
dc.authorid bayraktar ekmekcigil, oznur/0000-0002-4824-9943
dc.authorid Devrim, Gozuacik/0000-0001-7739-2346
dc.authorid Kutlu, Ozlem/0000-0002-3769-2536
dc.authorscopusid 57191667743
dc.authorscopusid 56294857000
dc.authorscopusid 10244182600
dc.authorscopusid 57172329700
dc.authorscopusid 6507315780
dc.authorscopusid 35728685000
dc.authorwosid kig, cenk/ABI-4009-2020
dc.authorwosid Kocaturk, Nur/V-3125-2018
dc.authorwosid Akkoc, Yunus/AAK-8853-2020
dc.authorwosid Abdulsalam, Raghad/AAR-5226-2021
dc.authorwosid bayraktar ekmekcigil, oznur/GRO-1353-2022
dc.authorwosid Devrim, Gozuacik/C-3330-2008
dc.authorwosid bayraktar ekmekcigil, oznur/GOG-8239-2022
dc.contributor.author Kocaturk, Nur Mehpare
dc.contributor.author Akkoc, Yunus
dc.contributor.author Kig, Cenk
dc.contributor.author Bayraktar, Oznur
dc.contributor.author Gozuacik, Devrim
dc.contributor.author Kutlu, Ozlem
dc.date.accessioned 2024-05-25T11:41:43Z
dc.date.available 2024-05-25T11:41:43Z
dc.date.issued 2019
dc.department Okan University en_US
dc.department-temp [Kocaturk, Nur Mehpare; Gozuacik, Devrim; Kutlu, Ozlem] Sabanci Univ, Nanotechnol Res & Applicat Ctr SUNUM, Orta Mah Univ Cad 27, TR-34956 Istanbul, Turkey; [Akkoc, Yunus; Gozuacik, Devrim] Sabanci Univ, Mol Biol Genet & Bioengn Program, Fac Engn & Nat Sci, TR-34956 Istanbul, Turkey; [Kig, Cenk] Istanbul Yeni Yuzyil Univ, Fac Med, TR-34010 Istanbul, Turkey; [Bayraktar, Oznur] Okan Univ, Dept Med Biol & Genet, Fac Med, Istanbul, Turkey en_US
dc.description kig, cenk/0000-0002-6318-5001; Kocaturk, Nur/0000-0002-4452-9913; Akkoc, Yunus/0000-0001-5379-6151; bayraktar ekmekcigil, oznur/0000-0002-4824-9943; Devrim, Gozuacik/0000-0001-7739-2346; Kutlu, Ozlem/0000-0002-3769-2536 en_US
dc.description.abstract Autophagy is an evolutionarily conserved catabolic mechanism, by which eukaryotic cells recycle or degrades internal constituents through membrane-trafficking pathway. Thus, autophagy provides the cells with a sustainable source of biomolecules and energy for the maintenance of homeostasis under stressful conditions such as tumor microenvironment. Recent findings revealed a close relationship between autophagy and malignant transformation. However, due to the complex dual role of autophagy in tumor survival or cell death, efforts to develop efficient treatment strategies targeting the autophagy/cancer relation have largely been unsuccessful. Here we review the two-faced role of autophagy in cancer as a tumor suppressor or as a pro-oncogenic mechanism. In this sense, we also review the shared regulatory pathways that play a role in autophagy and malignant transformation. Finally, anti-cancer therapeutic agents used as either inhibitors or inducers of autophagy have been discussed. en_US
dc.description.sponsorship Scientific and Technological Research Council of Turkey (TUBITAK)-1001 [114Z836]; TUBITAK-BIDEB 2211 en_US
dc.description.sponsorship This work was supported by Scientific and Technological Research Council of Turkey (TUBITAK)-1001 Grant number: 114Z836. YA is supported by TUBITAK-BIDEB 2211 Scholarships for his PhD studies. en_US
dc.identifier.citationcount 251
dc.identifier.doi 10.1016/j.ejps.2019.04.011
dc.identifier.endpage 137 en_US
dc.identifier.issn 0928-0987
dc.identifier.issn 1879-0720
dc.identifier.pmid 30981885
dc.identifier.scopus 2-s2.0-85064667322
dc.identifier.scopusquality Q1
dc.identifier.startpage 116 en_US
dc.identifier.uri https://doi.org/10.1016/j.ejps.2019.04.011
dc.identifier.uri https://hdl.handle.net/20.500.14517/1546
dc.identifier.volume 134 en_US
dc.identifier.wos WOS:000468081200010
dc.identifier.wosquality Q2
dc.language.iso en
dc.publisher Elsevier en_US
dc.relation.ispartof Annual Meeting of the European-Federation-of-Pharmaceutical-Sciences (EUFEPS) -- MAY 24-26, 2018 -- Athens, GREECE en_US
dc.relation.publicationcategory Konferans Öğesi - Uluslararası - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 302
dc.subject Autophagy en_US
dc.subject Cancer en_US
dc.subject Therapeutic agents en_US
dc.title Autophagy as a molecular target for cancer treatment en_US
dc.type Conference Object en_US
dc.wos.citedbyCount 283

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