Changes in Antimicrobial Resistance of Urinary Tract Infections in Adult Patients over a 5-Year Period

dc.authorid Vahaboglu, H/0000-0001-8217-1767
dc.authorid Culpan, Meftun/0000-0001-8573-1192
dc.authorid caskurlu, hulya/0000-0002-6760-2052
dc.authorscopusid 6507367274
dc.authorscopusid 57192680827
dc.authorscopusid 7004932286
dc.authorscopusid 42162301800
dc.authorscopusid 6603778078
dc.authorscopusid 6602450251
dc.authorwosid Vahaboglu, H/HHZ-1169-2022
dc.authorwosid Çulpan, Meftun/AAC-9624-2019
dc.authorwosid Culpan, Meftun/AAR-6117-2021
dc.authorwosid Culpan, Meftun/GPX-3240-2022
dc.authorwosid caskurlu, hulya/ABI-3919-2020
dc.contributor.author Caskurlu, Hulya
dc.contributor.author Culpan, Meftun
dc.contributor.author Erol, Bulent
dc.contributor.author Turan, Turgay
dc.contributor.author Vahaboglu, Haluk
dc.contributor.author Caskurlu, Turhan
dc.date.accessioned 2024-05-25T12:29:58Z
dc.date.available 2024-05-25T12:29:58Z
dc.date.issued 2020
dc.department Okan University en_US
dc.department-temp [Caskurlu, Hulya; Vahaboglu, Haluk] Istanbul Medeniyet Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey; [Culpan, Meftun] Istanbul Okan Univ, Fac Med, Dept Urol, Istanbul, Turkey; [Erol, Bulent; Caskurlu, Turhan] Istanbul Medeniyet Univ, Gortepe Training & Res Hosp, Fac Med, Dept Urol, Istanbul, Turkey; [Turan, Turgay] Turgutlu State Hosp, Dept Urol, Manisa, Turkey en_US
dc.description Vahaboglu, H/0000-0001-8217-1767; Culpan, Meftun/0000-0001-8573-1192; caskurlu, hulya/0000-0002-6760-2052 en_US
dc.description.abstract Objectives: We aimed to determine the most common bacteria that cause urinary tract infections (UTIs), the rate of antibiotic resistance of these uropathogens, and the changes in resistance rates over the years for adult patients diagnosed with UTIs. Methods: We retrospectively reviewed urine cultures and antibiotic susceptibility results of patients >17 years of age from our outpatient clinic between 2014 and 2018. The most common uropathogens and their antibiotic resistance rates were identified in different age groups (18-39, 40-59, and >= 60 years) and with respect to gender and date of admission. In addition, the change in antibiotic resistance of Escherichia coli between 2014 and 2018 was also examined. Results: A total of 9,556 positive urine cultures were included. The most common uropathogen was E. coli, and its prevalence was higher in females than males (70.6 vs. 53.4%, respectively). The majority of isolates were from patients >= 60 years of age. E. coli resistance was most pronounced for ampicillin (61.56%), followed by trimeth-oprim-sulfamethoxazole (49.80%), amoxicillin-clavulanic acid (34.69%), and cefazolin (30.72%). E. coli resistance to ampicillin, nitrofurantoin, cefepime, ciprofloxacin, fosfomycin, and amoxicillin-clavulanic acid increased significantly with time (all p = 0.001). For E. coli, resistance to ciprofloxacin, one of the most commonly used antibiotics for UTI, increased from 17 to 43% from 2014 to 2018. Conclusion: Most of the uropathogens displayed high resistance to ampicillin, tri-methoprim-sulfamethoxazole, and amoxicillin-clavulanic acid, and were susceptible to meropenem, ertapenem, and imipenem. Fosfomycin and cefepime were useful in the empirical treatment of community-acquired UTIs. A surprisingly high increase was observed in the resistance of E. coli to antimicrobial agents from 2014 to 2018. en_US
dc.identifier.citationcount 11
dc.identifier.doi 10.1159/000504415
dc.identifier.endpage 292 en_US
dc.identifier.issn 0042-1138
dc.identifier.issn 1423-0399
dc.identifier.issue 3-4 en_US
dc.identifier.pmid 31940639
dc.identifier.scopus 2-s2.0-85078290560
dc.identifier.scopusquality Q2
dc.identifier.startpage 287 en_US
dc.identifier.uri https://doi.org/10.1159/000504415
dc.identifier.uri https://hdl.handle.net/20.500.14517/2165
dc.identifier.volume 104 en_US
dc.identifier.wos WOS:000533868200018
dc.identifier.wosquality Q4
dc.language.iso en
dc.publisher Karger en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 16
dc.subject Antimicrobial resistance en_US
dc.subject Urinary tract infections en_US
dc.subject Uropathogens en_US
dc.subject Outpatient urine culture en_US
dc.title Changes in Antimicrobial Resistance of Urinary Tract Infections in Adult Patients over a 5-Year Period en_US
dc.type Article en_US
dc.wos.citedbyCount 14

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