Targeting vimentin: a multifaceted approach to combatting cancer metastasis and drug resistance

dc.authorid mirian, mina/0000-0002-9322-2707
dc.authorid Tabatabaee, Aliye/0000-0002-9240-7662
dc.authorscopusid 57211586393
dc.authorscopusid 58242617300
dc.authorscopusid 57217416009
dc.authorscopusid 57211494513
dc.authorscopusid 57202500098
dc.authorscopusid 23483174100
dc.authorscopusid 23483174100
dc.authorwosid mirian, mina/F-3134-2018
dc.contributor.author Tabatabaee, Aliye
dc.contributor.author Nafari, Behjat
dc.contributor.author Farhang, Armin
dc.contributor.author Hariri, Amirali
dc.contributor.author Khosravi, Arezoo
dc.contributor.author Zarrabi, Ali
dc.contributor.author Mirian, Mina
dc.date.accessioned 2024-05-25T11:38:56Z
dc.date.available 2024-05-25T11:38:56Z
dc.date.issued 2023
dc.department Okan University en_US
dc.department-temp [Tabatabaee, Aliye; Nafari, Behjat; Farhang, Armin; Hariri, Amirali; Mirian, Mina] Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Dept Pharmaceut Biotechnol, Esfahan 8174673461, Iran; [Khosravi, Arezoo] Istanbul Okan Univ, Fac Engn & Nat Sci, Dept Genet & Bioengn, TR-34959 Istanbul, Turkiye; [Zarrabi, Ali] Istinye Univ, Fac Engn & Nat Sci, Dept Biomed Engn, TR-34396 Istanbul, Turkiye; [Zarrabi, Ali] Saveetha Univ, Saveetha Inst Med & Tech Sci, Saveetha Dent Coll & Hosp, Chennai 600077, India en_US
dc.description mirian, mina/0000-0002-9322-2707; Tabatabaee, Aliye/0000-0002-9240-7662 en_US
dc.description.abstract This comprehensive review explores vimentin as a pivotal therapeutic target in cancer treatment, with a primary focus on mitigating metastasis and overcoming drug resistance. Vimentin, a key player in cancer progression, is intricately involved in processes such as epithelial-to-mesenchymal transition (EMT) and resistance mechanisms to standard cancer therapies. The review delves into diverse vimentin inhibition strategies. Precision tools, including antibodies and nanobodies, selectively neutralize vimentin's pro-tumorigenic effects. DNA and RNA aptamers disrupt vimentin-associated signaling pathways through their adaptable binding properties. Innovative approaches, such as vimentin-targeted vaccines and microRNAs (miRNAs), harness the immune system and post-transcriptional regulation to combat vimentin-expressing cancer cells. By dissecting vimentin inhibition strategies across these categories, this review provides a comprehensive overview of anti-vimentin therapeutics in cancer treatment. It underscores the growing recognition of vimentin as a pivotal therapeutic target in cancer and presents a diverse array of inhibitors, including antibodies, nanobodies, DNA and RNA aptamers, vaccines, and miRNAs. These multifaceted approaches hold substantial promise for tackling metastasis and overcoming drug resistance, collectively presenting new avenues for enhanced cancer therapy. en_US
dc.description.sponsorship Vice-presidency for Research of Isfahan University of Medical Sciences, Isfahan [3400778, 199438] en_US
dc.description.sponsorship The authors appreciate the financial support of the Vice-presidency for Research of Isfahan University of Medical Sciences, Isfahan (Grant No. 3400778 and 199438). en_US
dc.identifier.citationcount 4
dc.identifier.doi 10.1007/s10555-023-10154-7
dc.identifier.issn 0167-7659
dc.identifier.issn 1573-7233
dc.identifier.pmid 38012357
dc.identifier.scopus 2-s2.0-85178355176
dc.identifier.scopusquality Q1
dc.identifier.uri https://doi.org/10.1007/s10555-023-10154-7
dc.identifier.uri https://hdl.handle.net/20.500.14517/1309
dc.identifier.wos WOS:001107128400001
dc.identifier.wosquality Q1
dc.institutionauthor Khosravi A.
dc.language.iso en
dc.publisher Springer en_US
dc.relation.publicationcategory Diğer en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 11
dc.subject Vimentin en_US
dc.subject Metastasis en_US
dc.subject Plasticity en_US
dc.subject Drug resistance en_US
dc.subject Inhibitor en_US
dc.subject EMT en_US
dc.title Targeting vimentin: a multifaceted approach to combatting cancer metastasis and drug resistance en_US
dc.type Review en_US
dc.wos.citedbyCount 10

Files