Histopathological and biochemical evaluation of the effect of Paeoniflorin on the periodontium during and after periodontitis formation in rats

dc.authorid CIFTCI, ALPER/0000-0001-8370-8677
dc.authorid KURT BAYRAKDAR, Sevda/0000-0002-3711-6520
dc.authorscopusid 57202306502
dc.authorscopusid 57208276020
dc.authorscopusid 57208276240
dc.authorscopusid 34980023500
dc.authorscopusid 25225387700
dc.authorscopusid 56463728100
dc.authorscopusid 56463728100
dc.authorwosid CIFTCI, ALPER/AAD-9374-2022
dc.authorwosid kurt bayrakdar, sevda/AFV-9029-2022
dc.contributor.author Kurt, Sevda
dc.contributor.author Gurkan, Cagla Gul
dc.contributor.author Tezal, Gonca Cayir Keles
dc.contributor.author Ciftci, Alper
dc.contributor.author Gurgor, Pinar Naile
dc.contributor.author Guler, Sevki
dc.contributor.author Cetinkaya, Burcu Ozkan
dc.date.accessioned 2024-05-25T11:41:38Z
dc.date.available 2024-05-25T11:41:38Z
dc.date.issued 2019
dc.department Okan University en_US
dc.department-temp [Kurt, Sevda] Recep Tayyip Erdogan Univ, Fac Dent, Dept Periodontol, TR-53100 Rize, Turkey; [Gurkan, Cagla Gul] Bafra Publ Oral Hlth Ctr, Samsun, Turkey; [Tezal, Gonca Cayir Keles] Istanbul Okan Univ, Fac Dent, Dept Periodontol, Istanbul, Turkey; [Ciftci, Alper] Ondokuz Mayis Univ, Fac Vet Med, Dept Microbiol, Samsun, Turkey; [Gurgor, Pinar Naile] Ordu Univ, Fac Med, Dept Histol & Embriol, Ordu, Turkey; [Guler, Sevki] Abant Izzet Baysal Univ, Fac Dent, Dept Periodontol, Bolu, Turkey; [Cetinkaya, Burcu Ozkan] Ondokuz Mayis Univ, Fac Dent, Dept Periodontol, Samsun, Turkey en_US
dc.description CIFTCI, ALPER/0000-0001-8370-8677; KURT BAYRAKDAR, Sevda/0000-0002-3711-6520 en_US
dc.description.abstract Objectives: Appraise the effect of systemic Paeoniflorin (Pae) application on the periodontium during and after induction of experimental periodontitis in the presence of ligature and after its removal. Design: Seventy male Wistar rats were separated into seven equal groups. The first group was reserved as healthy control group (Group 1: no periodontitis, no medication) and experimental periodontitis was induced with ligature in the remaining rats. In experimental periodontitis groups, Pae or saline was administered systemically in three differet periods; during the experimental periodontitis induction (period 1), after experimental periodontitis induction which ligature removed (period 2) or ligature kept in position (period 3). Only, one of the groups acted as the control periodontitis group and received no treatment. Experimental periodontitis groups were as follows; Group 2: medication in period 1, Group 3: periodontitis and no medication, Group 4: medication in period 2, Group 5: saline application in period 2, Group 6: medication in period 3, Group 7: saline application in period 3. Matrix metalloproteinases-9 (MMP-9) levels and interleukin-10 (IL-10) levels were detected biochemically and histomorphometric analyses were performed. These analyses included measurements of the area of alveolar bone, the level of alveolar bone, and attachment loss. Results: Area of alveolar bone and IL-10 levels were higher in the Pae-administered groups; level of alveolar bone, attachment loss, and MMP-9 levels were correspondingly lower (P < 0.05). The beneficial effects at histomorphometrical and biochemical levels of Pae were the strongest in the rats that were administered Pae after the removal of ligature. Conclusions: Systemically administered Pae had a positive effect on the healing of periodontal tissues. Pae can be used as a new therapeutic agent for periodontal diseases, but microbiology-based studies and more extensive biochemistry-based experimental and clinical studies are needed to address this possibility. en_US
dc.description.sponsorship Scientific and Technological Research Council of Turkey (TUBITAK) [115S846] en_US
dc.description.sponsorship This study was supported by the The Scientific and Technological Research Council of Turkey (TUBITAK) (Project number: 115S846). en_US
dc.identifier.citationcount 5
dc.identifier.doi 10.1016/j.archoralbio.2019.04.006
dc.identifier.endpage 140 en_US
dc.identifier.issn 0003-9969
dc.identifier.issn 1879-1506
dc.identifier.pmid 31005686
dc.identifier.scopus 2-s2.0-85064322698
dc.identifier.scopusquality Q3
dc.identifier.startpage 135 en_US
dc.identifier.uri https://doi.org/10.1016/j.archoralbio.2019.04.006
dc.identifier.uri https://hdl.handle.net/20.500.14517/1540
dc.identifier.volume 102 en_US
dc.identifier.wos WOS:000471206900018
dc.identifier.wosquality Q2
dc.language.iso en
dc.publisher Pergamon-elsevier Science Ltd en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 3
dc.subject Experimental periodontitis en_US
dc.subject Histology en_US
dc.subject Matrix metalloproteinase(s) en_US
dc.subject Cytokines en_US
dc.title Histopathological and biochemical evaluation of the effect of Paeoniflorin on the periodontium during and after periodontitis formation in rats en_US
dc.type Article en_US
dc.wos.citedbyCount 5

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