TRPM2 may be involved in high fructose corn syrup-induced anxiety-like behavior in adult male rats

dc.authorid ULKER ERTUGRUL, Nazife/0000-0002-3805-2362
dc.authorid kuloğlu, tuncay/0000-0001-9874-3838
dc.authorid Tan, Fatih/0000-0003-2995-4628
dc.authorid Yardimci, Ahmet/0000-0001-5740-9518
dc.authorscopusid 18038758400
dc.authorscopusid 58072738800
dc.authorscopusid 57321809100
dc.authorscopusid 57469814100
dc.authorscopusid 56985668900
dc.authorscopusid 58348271000
dc.authorscopusid 7102067803
dc.authorwosid ULKER ERTUGRUL, Nazife/W-5686-2018
dc.authorwosid kuloğlu, tuncay/W-2310-2018
dc.authorwosid Yardimci, Ahmet/Q-2185-2015
dc.contributor.author Serhatlioglu, Ihsan
dc.contributor.author Zorlu, Gokhan
dc.contributor.author Yardimci, Ahmet
dc.contributor.author Ertugrul, Nazife Ulker
dc.contributor.author Ercan, Zubeyde
dc.contributor.author Tan, Fatih
dc.contributor.author Kelestimur, Haluk
dc.contributor.other Fizyoloji / Physiology
dc.date.accessioned 2024-05-25T11:26:02Z
dc.date.available 2024-05-25T11:26:02Z
dc.date.issued 2023
dc.department Okan University en_US
dc.department-temp [Serhatlioglu, Ihsan; Zorlu, Gokhan; Ozcan, Mete] Firat Univ, Fac Med, Dept Biophys, Elazig, Turkiye; [Yardimci, Ahmet; Ertugrul, Nazife Ulker; Kacar, Emine] Firat Univ, Fac Med, Dept Physiol, Elazig, Turkiye; [Ercan, Zubeyde] Firat Univ, Fac Hlth Sci, Dept Phys Therapy & Rehabil, Elazig, Turkiye; [Tan, Fatih] Osmaniye Korkut Ata Univ, Vocat Sch Hlth Serv, Osmaniye, Turkiye; [Bulmus, Ozgur] Balikesir Univ, Fac Med, Dept Physiol, Balikesir, Turkiye; [Bulmus, Funda Gulcu] Balikesir Univ, Fac Hlth Sci, Dept Nutr & Dietet, Balikesir, Turkiye; [Tektemur, Nalan Kaya; Kuloglu, Tuncay] Firat Univ, Fac Med, Dept Histol & Embryol, Elazig, Turkiye; [Kelestimur, Haluk] Istanbul Okan Univ, Fac Med, Dept Physiol, Istanbul, Turkiye en_US
dc.description ULKER ERTUGRUL, Nazife/0000-0002-3805-2362; kuloğlu, tuncay/0000-0001-9874-3838; Tan, Fatih/0000-0003-2995-4628; Yardimci, Ahmet/0000-0001-5740-9518 en_US
dc.description.abstract Excessive high fructose corn syrup (HFCS) consumption is known to cause oxidative stress, which induces transient receptor potential melastatin type 2 (TRPM2) channel gating. Oxidative stress-induced TRPM2 gating is suggested to play an important role in neurons, indicating a role for the TRPM2 channel in a variety of neuropsychiatric disorders including depression and anxiety. We investigated the effects of HFCS and chronic immobilization stress (CIS) on TRPM2 channel immunoreactivity, anxiety, and depressive-like behaviors in adult male rats. The male rats (n=8/group) were divided into 4 groups: Control, 20% HFCS (F20), 40% HFCS (F40), and stress. The control group received tap water, and F20 and F40 groups were exposed to 20% and 40% HFCS respectively for 14 consecutive days. Rats in the stress group were subjected to immobilization stress for 3 or 6 hours daily in the first and second weeks to induce CIS. Then, light/dark test, open field test (OFT), and tail suspension test (TST) were performed, respectively. In the light/dark test, the time spent in the dark chamber significantly increased in all groups vs the control group (P<0.01). In support of this result, the time spent in the light chamber significantly decreased in all groups vs the control group (P<0.01). Besides, CIS significantly increased depressive-like behavior in the stress group vs the control group (P<0.05). In serum hormone levels, corticosterone (CORT) levels significantly increased in the F40 and stress groups vs the control group (P<0.01). TRPM2 immunoreactivity significantly increased in the hippocampus, prefrontal cortex (PFC), nucleus accumbens (NaC), and amygdala regions by HFCS and CIS treatments. For the first time the present study showed that increased immunoreactivity of the TRPM2 cation channels may be linked to the anxiety-like behavior induced by HFCS. en_US
dc.description.sponsorship Firat University Scientific Research Projects Unit [TF.17.29] en_US
dc.description.sponsorship This research was funded by Firat University Scientific Research Projects Unit (Project No: TF.17.29) . en_US
dc.identifier.citationcount 0
dc.identifier.doi 10.14715/cmb/2023.69.3.3
dc.identifier.endpage 22 en_US
dc.identifier.issn 0145-5680
dc.identifier.issn 1165-158X
dc.identifier.issue 3 en_US
dc.identifier.pmid 37300693
dc.identifier.scopus 2-s2.0-85162953441
dc.identifier.scopusquality Q4
dc.identifier.startpage 13 en_US
dc.identifier.uri https://doi.org/10.14715/cmb/2023.69.3.3
dc.identifier.uri https://hdl.handle.net/20.500.14517/954
dc.identifier.volume 69 en_US
dc.identifier.wos WOS:001017190100003
dc.identifier.wosquality Q4
dc.institutionauthor Kelestimur H.
dc.language.iso en
dc.publisher C M B Assoc en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 0
dc.subject Anxiety en_US
dc.subject depression en_US
dc.subject high fructose corn syrup en_US
dc.subject oxidative stress en_US
dc.subject chronic immobilization stress en_US
dc.subject TRPM2 en_US
dc.title TRPM2 may be involved in high fructose corn syrup-induced anxiety-like behavior in adult male rats en_US
dc.type Article en_US
dc.wos.citedbyCount 0

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