Carbon-Based Nanozymes for Cancer Therapy and Diagnosis: a Review

dc.authorscopusid 56405640000
dc.authorscopusid 6505498701
dc.authorscopusid 57202500098
dc.authorscopusid 59458310300
dc.authorscopusid 56732944400
dc.authorscopusid 23483174100
dc.authorscopusid 23483174100
dc.contributor.author Cordani, Marco
dc.contributor.author Fernandez-Lucas, Jesus
dc.contributor.author Khosravi, Arezoo
dc.contributor.author Zare, Ehsan Nazarzadeh
dc.contributor.author Makvandi, Pooyan
dc.contributor.author Zarrabi, Ali
dc.contributor.author Iravani, Siavash
dc.date.accessioned 2025-02-17T18:48:55Z
dc.date.available 2025-02-17T18:48:55Z
dc.date.issued 2025
dc.department Okan University en_US
dc.department-temp [Cordani, Marco; Fernandez-Lucas, Jesus] Univ Complutense Madrid, Fac Biol, Dept Biochem & Mol Biol, C Jose Antonio Novais 12, Madrid 28040, Spain; [Cordani, Marco] Inst Invest Sanitarias San Carlos IdISSC, E-28040 Madrid, Spain; [Fernandez-Lucas, Jesus] Univ Europea Madrid, Appl Biotechnol Grp, E-28670 Madrid, Spain; [Fernandez-Lucas, Jesus] Univ Costa, Grp Invest Ciencias Nat & Exactas, GICNEX, CUC, Calle 58 55-66, Barranquilla 080002, Colombia; [Khosravi, Arezoo] Istanbul Okan Univ, Fac Engn & Nat Sci, Dept Genet & Bioengn, TR-34959 Istanbul, Turkiye; [Zare, Ehsan Nazarzadeh] Damghan Univ, Sch Chem, Damghan 3671645667, Iran; [Zare, Ehsan Nazarzadeh] Chitkara Univ, Inst Engn & Technol, Ctr Res Impact & Outcome, Rajpura 140401, Punjab, India; [Makvandi, Pooyan] Wenzhou Med Univ, Quzhou Affiliated Hosp, Quzhou Peoples Hosp, Quzhou 324000, Zhejiang, Peoples R China; [Makvandi, Pooyan] Chitkara Univ, Chitkara Ctr Res & Dev, Kalujhanda 174103, Himachal Prades, India; [Makvandi, Pooyan] Chandigarh Univ, Univ Ctr Res & Dev, Mohali 140413, Punjab, India; [Zarrabi, Ali] Istinye Univ, Fac Engn & Nat Sci, Dept Biomed Engn, Istanbul, Turkiye; [Zarrabi, Ali] Yuan Ze Univ, Grad Sch Biotechnol & Bioengn, Taoyuan, Taiwan; [Zarrabi, Ali] Saveetha Univ, Saveetha Dent Coll & Hosp, Saveetha Inst Med & Tech Sci, Dept Res Analyt, Chennai, India; [Iravani, Siavash] W Nazar ST,Boostan Ave, Esfahan, Iran en_US
dc.description.abstract Carbon-based nanozymes (CNs) have emerged as a significant innovation in targeted cancer therapy, demonstrating great potential for advancing cancer diagnosis and treatment. With exceptional catalytic properties, remarkable biocompatibility, and the ability to precisely target cancer cells, CNs provide a promising avenue for the development of novel oncological therapies. By functionalizing their surfaces with targeting ligands, such as antibodies or peptides, CNs can specifically recognize and bind to cancer cells. This targeted approach ensures that therapeutic agents are delivered directly to the tumor site, minimizing off-target effects, and reducing systemic toxicity. Additionally, the enzyme-like activities of CNs, when combined with conventional therapies such as chemotherapeutics, photothermal therapy, and photodynamic therapy, or other modalities can enhance therapeutic outcomes. Integrating CNs into clinical practice could significantly improve therapeutic efficacy, reduce probable side effects, enhance patient outcomes, and drive a shift towards more personalized cancer care. Besides, CNs can also be employed in biosensors and diagnostic nanomaterials, enabling rapid, selective, and highly accurate detection of specific biomarkers. Their versatile functionalities open new avenues for refining imaging techniques, ultimately contributing to early diagnosis and better clinical decision-making. This review consolidates recent studies exploring CNs in cancer targeting, highlighting both their diagnostic and therapeutic potential in oncology. en_US
dc.description.sponsorship MICIU/AEI [RYC2021-031003I]; European Union Next GenerationEU/PRTR en_US
dc.description.sponsorship M.C. is supported by grant RYC2021-031003I funded by MICIU/AEI/10.13039/501100011033 and, by European Union Next GenerationEU/PRTR. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.citationcount 0
dc.identifier.doi 10.1016/j.ijbiomac.2025.139704
dc.identifier.issn 0141-8130
dc.identifier.issn 1879-0003
dc.identifier.pmid 39793785
dc.identifier.scopus 2-s2.0-85215442115
dc.identifier.scopusquality Q1
dc.identifier.uri https://doi.org/10.1016/j.ijbiomac.2025.139704
dc.identifier.uri https://hdl.handle.net/20.500.14517/7651
dc.identifier.volume 297 en_US
dc.identifier.wos WOS:001414369400001
dc.identifier.wosquality Q1
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.relation.publicationcategory Diğer en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 0
dc.subject Carbon-Based Nanozymes en_US
dc.subject Precision Oncology en_US
dc.subject Targeted Cancer Therapy en_US
dc.title Carbon-Based Nanozymes for Cancer Therapy and Diagnosis: a Review en_US
dc.type Review en_US
dc.wos.citedbyCount 0

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