Functional and structural changes of the urinary bladder following spinal cord injury; treatment with alpha lipoic acid

dc.authorid Yegen, Berrak/0000-0003-0791-0165
dc.authorid Hakan, Tayfun/0000-0003-1444-7076
dc.authorid Yegen, Berrak C./0000-0003-0791-0165
dc.authorid Şener, Göksel/0000-0001-7444-6193
dc.authorid KUMRAL, Zarife Nigâr ÖZDEMİR/0000-0002-9485-0174
dc.authorid Hakan, Tayfun/0000-0003-1444-7076
dc.authorscopusid 57190747745
dc.authorscopusid 55919047400
dc.authorscopusid 6503989986
dc.authorscopusid 56001628300
dc.authorscopusid 8572934700
dc.authorscopusid 24079789000
dc.authorscopusid 55662834600
dc.authorwosid Yegen, Berrak/O-6652-2017
dc.authorwosid Hakan, Tayfun/P-8626-2015
dc.authorwosid Yegen, Berrak C./ABA-1986-2020
dc.authorwosid Şener, Göksel/AAN-4461-2021
dc.authorwosid KUMRAL, Zarife Nigâr ÖZDEMİR/AAG-1861-2020
dc.authorwosid Hakan, Tayfun/O-9979-2019
dc.authorwosid Yegen, Berrak/ABA-3274-2020
dc.contributor.author Ekiz, Arif
dc.contributor.author Ozdemir-Kumral, Zarife Nigar
dc.contributor.author Ersahin, Mehmet
dc.contributor.author Tugtepe, Halil
dc.contributor.author Ogunc, Ayliz Velioglu
dc.contributor.author Akakin, Dilek
dc.contributor.author Toklu, Hale Z.
dc.date.accessioned 2024-05-25T11:20:18Z
dc.date.available 2024-05-25T11:20:18Z
dc.date.issued 2017
dc.department Okan University en_US
dc.department-temp [Ekiz, Arif; Sener, Goksel] Marmara Univ, Sch Pharm, Dept Pharmacol, Istanbul, Turkey; [Ozdemir-Kumral, Zarife Nigar; Yegen, Berrak C.] Marmara Univ, Sch Med, Dept Physiol, Istanbul, Turkey; [Ersahin, Mehmet] Medeniyet Univ, Sch Med, Dept Neurosurg, Istanbul, Turkey; [Tugtepe, Halil] Marmara Univ, Sch Med, Dept Pediat Surg, Istanbul, Turkey; [Ogunc, Ayliz Velioglu] Marmara Univ, Vocat Sch Hlth Related Profess, Istanbul, Turkey; [Akakin, Dilek; Kiran, Demir] Marmara Univ, Sch Med, Dept Histol & Embryol, Istanbul, Turkey; [Ozsavci, Derya] Marmara Univ, Sch Pharm, Dept Biochem, Istanbul, Turkey; [Biber, Necat] Haydarpasa Numune Teaching & Res Hosp, Dept Neurosurg, Istanbul, Turkey; [Hakan, Tayfun] Okan Univ, Kolan Int Hosp, Vocat Sch Hlth Serv, Dept Neurosurg, Istanbul, Turkey; [Toklu, Hale Z.] Univ Florida, Coll Med, Dept Pharmacol & Therapeut, 1200 Newell Dr,PO 100267, Gainesville, FL 32610 USA; [Toklu, Hale Z.] Malcom Randall Vet Affairs Med Ctr, Geriatr Res Educ & Clin Ctr, Gainesville, FL USA en_US
dc.description Yegen, Berrak/0000-0003-0791-0165; Hakan, Tayfun/0000-0003-1444-7076; Yegen, Berrak C./0000-0003-0791-0165; Şener, Göksel/0000-0001-7444-6193; KUMRAL, Zarife Nigâr ÖZDEMİR/0000-0002-9485-0174; Hakan, Tayfun/0000-0003-1444-7076; Toklu, Hale/0000-0002-9797-3591; en_US
dc.description.abstract BACKGROUND & AIMAlpha lipoic acid (LA) was shown to exert neuroprotection in trauma-induced spinal cord injury (SCI), which is frequently associated with urinary bladder complaints in patients with SCI. Accordingly, the protective effects of LA on biochemical and histological changes in bladder as well as functional studies were assessed. METHODSWistar albino rats were divided as control, SCI, and LA (50mg/kg/day, ip) treated SCI groups (SCI+LA). The standard weight-drop (100g/cm force at T10) method was used to induce a moderately severe SCI. One week after the injury, neurological examination was performed and the rats were decapitated. Bladder samples were taken for histological examination, functional (isolated tissue bath) studies, and for the measurement of biochemical parameters (malondialdehyde, MDA; gluthathione, GSH; nerve growth factor, NGF; caspase-3, luminol and lucigenin chemiluminescences). RESULTSSCI caused a significant (P<0.001) increase in the detrusor muscle thickness. It increased the contractility responses to carbachol and relaxation responses to papaverine (P<0.05-0.001). There were also significant alterations in MDA, caspase-3, luminol, and lucigenin chemiluminescences with concomitant decreases in NGF and GSH (P<0.05). LA treatment reversed histological and functional (contraction and relaxation responses) changes induced by SCI (P<0.05-0.001), but no significant recovery was observed in the impaired neurological functions. CONCLUSIONThese results indicate that LA have a beneficial effect in improving the bladder tonus via its antioxidant and anti-inflammatory actions following SCI. en_US
dc.identifier.citationcount 4
dc.identifier.doi 10.1002/nau.23083
dc.identifier.endpage 1068 en_US
dc.identifier.issn 0733-2467
dc.identifier.issn 1520-6777
dc.identifier.issue 4 en_US
dc.identifier.pmid 27490041
dc.identifier.scopus 2-s2.0-84982947890
dc.identifier.scopusquality Q2
dc.identifier.startpage 1061 en_US
dc.identifier.uri https://doi.org/10.1002/nau.23083
dc.identifier.uri https://hdl.handle.net/20.500.14517/462
dc.identifier.volume 36 en_US
dc.identifier.wos WOS:000400147000032
dc.identifier.wosquality Q3
dc.language.iso en
dc.publisher Wiley en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 7
dc.subject bladder en_US
dc.subject carbachol en_US
dc.subject caspase 3 en_US
dc.subject contractility en_US
dc.subject lipoic acid en_US
dc.subject NGF en_US
dc.subject NSE en_US
dc.subject papaverinee en_US
dc.subject relaxation en_US
dc.subject S100 en_US
dc.subject spinal cord injury en_US
dc.subject trauma en_US
dc.title Functional and structural changes of the urinary bladder following spinal cord injury; treatment with alpha lipoic acid en_US
dc.type Article en_US
dc.wos.citedbyCount 5

Files